學習及科研經曆

楊振華，華中科技大學同濟醫學院88858cc永利官网教授、博士生導師。2012年于武漢大學生命科學學院獲得微生學專業博士學位，2012-2018年在美國阿拉巴馬州-伯明翰大學從事博士後/助理研究員工作，2018年11月作為課題組長入職華中科技大學同濟88858cc永利官网。

研究領域：

本實驗室利用體内和體外各種研究方案，對造血幹細胞分化調控及血液腫瘤發生發展的分子機理進行深入研究，并緻力于在此基礎上的抗腫瘤轉化醫學研究。

聯系方式：

地址：同濟88858cc永利官网2号樓1221室; 郵箱：zhenhua@hust.edu.cn

發表主要論文

1. Zhenhua Yang*· Hao Jiang*. A chromatin perspective on metabolic and genotoxic impacts on hematopoietic stem and progenitor cells. Cellular and Molecular Life Sciences. 2020 https://doi.org/10.1007/s00018-020-03522-x

2. Zhenhua Yang*, Kushani Shah, Alireza Khodadadi-Jamayran, Hao Jiang*. Control of Hematopoietic Stem and Progenitor Cell Function Through Epigenetic Regulation of Energy Metabolism and Genome Integrity. Stem Cell Reports. 2019; 13, 61-75.

3. Zhenhua Yang^#, Kushani Shah^#, Theodore Busby, Robert Whitaker, Keith Giles, Alireza Khodadadi-Jamayran, Jing Hu, William Placzek, and Hao Jiang. Hijacking a key chromatin modulator creates targetable epigenetic vulnerability for Myc-driven cancer. Journal of Clinical Investigation. 2018;128, 3605-3618.

4. Zhenhua Yang, Kushani Shaha, Alireza Khodadadi-Jamayran, and Hao Jiang. Dpy30 Is Critical for Maintaining the Identity and Function of Adult Hematopoietic Stem Cells. The Journal of Experimental Medicine. 2016, doi/ 10.1084/jem.20160185.

5. Jing Hu, Alireza Khodadadi-Jamayran, Miaowei Mao, Kushani Shah, Zhenhua Yang, Talat Nasim, Zefeng Wang, and Hao Jiang†. AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors. Nature Communications. 2016 Nov 8;7:13347. doi: 10.1038/ ncomms13347.

6. Zhenhua Yang, Jonathan Augustin, Jing Hu, and Hao Jiang. Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors. PLoS One. 2015, 10(12): 0145336.

7. Zhenhua Yang^#, Jonathan Augustin^#, Chenbei Chang, Jing Hu, Kushani Shah, Chia-Wei Chang, Tim Townes, and Hao Jiang. The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. Blood. 2014, 124(13): 2025-33.

8. Zhenhua Yang, Wu R, Li RW, Li L, Xiong Z, Zhao H, Guo D, Pan Z. Chimeric classical swine fever (CSF)-Japanese encephalitis (JE) viral replicon as a non-transmissible vaccine candidate against CSF and JE infections. Virus Res. 2012 Apr; 165(1):61-70.

9. Zhenhua Yang, Ling Li, Zishu Pan. Development of multiple ELISAs for the detection of antibodies against classical swine fever virus in pig sera. Virologica Sinica. 2012, 27(1):48-56.

10. Jing Qu, Zhenhua Yang,  Qi Zhang, Weiyong Liu, Youxing Li, Qiong Ding, Fang Liu, Yingle Liu, Zishu Pan, Biao He, Ying Zhu, Jianguo Wu, Human immunodeficiency virus-1 Rev protein activates hepatitis C virus gene expression by directly targeting the HCV 5′-untranslated region. FEBS. 2011, 585: 4002-4009.

11. Zhenhua Yang, Pan Tao, Siyu Zhou, Shuwen Wu, Zishu Pan. Expression of neuraminidase of H5N1 subtype avian influenza virus and production of polyclonal antibody. Journal of WuHan University. 2007, 53:481-484.

# Equal contribution; *Corresponding author