李傳洲

專業方向：神經退行性疾病機理

個人簡介：2007年武漢大學生科院獲學士學位；2012年武漢大學獲得細胞生物學博士學位；2013-2018年澳大利亞昆士蘭腦研究所從事博士後研究。2018年4月入職88858cc永利官网醫學遺傳系，研究方向為阿爾茨海默病（AD）緻病機理。具體包括：1）AD中微管結合蛋白Tau和酪氨酸激酶Fyn的相互調控機理；2）Tau蛋白在胞體樹突中形成NFTs的機制；3）AD風險因子Pyk2對神經功能及學習記憶的影響。近年來發表唯一第一作者 J Azheimers Dis; 唯一第一作者EMBO J封面文章；唯一第一作者Nat. Rev. Drug. Discov封面文章；一作頂級眼科雜志Invest. Ophthalmol. Vis. Sci. 以及Acta Neuropathol. Commun.、Nat. Rev. Neurol.、BBA、BBRC等。

聯系方式： chuanzhouli@hust.edu.cn

聯系地址：同濟醫學院88858cc永利官网2号樓1220室

Li, C., Pandit, R., Li, L., Liu, H., Götz, J.(2019) Self-aggregates of Pyk2 induce ER stress-mediated neurodegeneration. (in preparation)

Li, C. and J. Götz, Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn. J Alzheimers Dis, 2018. 64(1): p. 205-221. （受Fyn調控的新型Tau酪氨酸激酶Pyk2；唯一第一作者；雜志網頁推薦文章；影響因子3.92）

Polanco, J.C., Li, C. Durisic, N. Sullivan, R. Götz, J. et al., Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons. Acta Neuropathol Commun, 2018. 6(1): p. 10.（影響因子5.414）

Polanco, J.C., Li, C., Bodea L.G., Marmol, R.M., Meunier, F., and Götz, J. (2017) Amyloid-beta and tau complexity - towards improved biomarkers and targeted therapies. Nat Rev Neurol, 2018. 14(1): p. 22-39.（β澱粉樣蛋白和tau的多态性—更好生物标志物和靶向治療；影響因子20.2）

Li, C. and J. Gotz (2017). "Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation." EMBO Journal 36(21): 3120-3138.（阿爾茲海默症中Fyn 介導的局部蛋白質合成促進了Tau在胞體樹突的聚集；唯一第一作者；影響因子9.792；權威學術論壇Alzforum 對此發表長篇評論；入選雜志封面）

Li, C. and J. Gotz (2017). "Tau-based therapies in neurodegeneration: opportunities and challenges." Nat Rev Drug Discov 16(12): 863-883.（以Tau為基礎的神經退行性疾病的多元化靶向治療；唯一第一作者；影響因子57 ）

Xia, D., Li, C., and Götz, J. (2015). "Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines." Biochim. Biophys. Acta. 1852(5): 913-924.（影響因子5.725）

Li, C., Wang, L., and Zheng, L. (2012). "Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol." Invest. Ophthalmol. Vis. Sci. 53(6): 3241-3249. (眼科研究型雜志中排名第一; 影響因子3.427）

Li, C., Wang, L., Huang, K., and Zheng, L. (2012). "Inhibition of poly(ADP-ribose) polymerase inhibits ischemia/reperfusion induced neurodegeneration in retina via suppression of endoplasmic reticulum stress." Biochem. Biophys. Res. Commun. 423(2):276-281.（影響因子：2.5559）

Wang, L., Li, C., Guo, H., Kern, T.S., Huang, K., and Zheng, L. (2011). Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reperfusion injury. PLoS ONE 6(8):e23194.（影響因子：2.766）

Sullivan, M.A., Li, J., Li, C., Vilaplana, F., Stapleton, D., Gray-Weale, A.A., Bowen, S., Zheng, L., and Gilbert ,R.G. (2011). Molecular structural differences between type-2-diabetic and healthy glycogen. Biomacromolecules 12(6):1983-1986.（影響因子：5.246）

Gong, H., Zhang, X., Cheng, B., Sun, Y., Li, C., Li, T., Zheng, L., and Huang, K. (2013). "Bisphenol a Accelerates Toxic Amyloid Formation of Human Islet Amyloid Polypeptide: A Possible Link between Bisphenol a Exposure and Type 2 Diabetes." PLoS One 8, no. 1:e54198.（影響因子：2.766）

Cheng, B., Liu, X., Gong, H., Huang, L., Chen, H., Zhang, X., Li, C., Yang, M., Ma, B., Jiao, L., Zheng, L. and Huang, K. (2011). Coffee Components Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in Vitro: Possible Link between Coffee Consumption and Diabetes Mellitus. J. Agric. Food Chem. 59(24):13147-13155.（影響因子：3.154）

         Zhang, X., Cheng, B., Gong, H., Li, C., Chen, H., Zheng, L., and Huang, K. (2011). Porcine is let amyloid polypeptide fragments are refractory to amyloid formation. FEBS Lett 585(1):71-77.（影響因子：2.999）