孫書國，博士生導師，教授，任88858cc永利官网解剖學系主任，武漢解剖學會會長。孫書國團隊長期從事Hippo信号通路和肺癌的發生、發展和腫瘤免疫方面的研究。以第一或通訊作者在Cell、Molecular Cell、Trends Cell Biology、Nature Communications等發表了多篇有影響力的論文多篇。獲得國家自然科學基金委、科技部重點研發計劃等多項研究項目的支持。

研究方向一：Hippo信号通路與肺癌。

研究方向二：肺癌驅動基因的鑒定和功能機制研究。

研究方向三：肺癌的腫瘤免疫學

聯系方式：shuguo@hust.edu.cn

近年發表的主要論著：（通訊作者^#）

1 Rauskolb, C. *, Sun, S.*, Sun, G., Pan, Y. & Irvine, K. D. ^# Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex. Cell158, 143-156, doi:10.1016/j.cell.2014.05.035 (2014).

2 Sun, S. * G., Reddy, B. V. V. G. & Irvine, K. D. ^# Localization of Hippo signalling complexes and Warts activation in vivo. Nature Communications6, doi:Artn 840210.1038/Ncomms9402 (2015).

3 Sun, S. *& Irvine, K. D. ^# Cellular Organization and Cytoskeletal Regulation of the Hippo Signaling Network. Trends Cell Biol26, 694-704, doi:10.1016/j.tcb.2016.05.003 (2016).

4 Mao, Y. *, Sun, S. *& D. Irvine, K^#. Role and Regulation of Yap in KrasG12D-induced lung cancer. Oncotarget, doi:10.18632/oncotarget.22865 (2017).

5 Yu, M. *, Zhengxin Peng*, et alShuguo Sun^#. Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation. Molecular Cell, doi:https://doi.org/10.1016/j.molcel.2021.01.010 (2021).

6 Zhengxin Peng*, Man Yu*, et al Shuguo Sun^#.Establishlung adenocarcinoma immunotherapy allograft model and analysis of the tumor response by flow cytometry and immunofluorescence. Star Protocol 2021 invited protocol (in press)