方敏，男，1966年1月出生，中共黨員，免疫學專業博士，華中科技大學同濟醫學院免疫學系三級教授，博士/碩士研究生導師。1983年9月-1989年7月在武漢同濟醫科大學本科學習，獲醫學學士學位；1993年9月-1996年7月在武漢同濟醫科大學攻讀碩士學位，獲免疫學專業碩士學位；2002年5月—2005年5月：德國杜塞爾多夫大學(Die Heinrich-Heine-Universität Düsseldor) 攻讀博士學位，獲免疫學專業博士學位。1996年7月—1999年8月：武漢同濟醫科大學88858cc永利官网免疫學教研室 助教，講師；1999年8月—2000年8月：維也納大學醫學院外科研究所 訪問學者。2005年5月-2010年10月：華中科技大學同濟醫學院免疫學教研室副教授。2010年11月-迄今：華中科技大學同濟醫學院免疫學教研室教授。中國免疫學會移植免疫分會委員，中德醫學會會員。主要研究方向為免疫耐受與移植免疫學;參與完成科技部重大基礎研究項目（973項目）2項；作為項目負責人已完成國家自然科學基金二項(2008.1-2010.12)：（Grant No.30772039）SOCS與IDO對移植排斥反應中Th17細胞的調節機制; (Grant No. 81072440) HMGB1誘生、趨化IL-17+γδT/Th17細胞參與移植排斥反應的作用與機制。目前作為項目負責人承擔國家自然科學基金二項：面上項目2014.1-2017.12(Grant No. 81373167）； 重大研究計劃培育項目：2016-2018（Grant No. 91542110）。代表性論文如下。

近期已發表主要論著(* 為通訊作者)：

1. Zhang Y, Li L, Qi C, Hua S, Fei X, Gong F, Fang M*.Glycyrrhizin alleviates Con A-induced hepatitis by differentially regulating the production of IL-17 and IL-25. Biomed Pharmacother. 2018 Dec 12; 110: 692-699.

2. Zhang Y, Qi C, Li L, Hua S, Zheng F, Gong F, Fang M*.CD8+ T cell/IL-33/ILC2 axis exacerbates the liver injury in Con A-induced hepatitis in T cell-transferred Rag2-deficient mice. Inflamm Res. 2018 Nov 14. doi: 10.1007/s00011-018-1197-9

3. Li Q, Li L, Fei X, Zhang Y, Qi C, Hua S, Gong F, Fang M*. Inhibition of autophagy with 3-methyladenine is protective in a lethal model of murine endotoxemia and polymicrobial sepsis. Innate Immunity. 2018; 24(4):231-239.

4. Chen X, Fang D, Li L, Chen L, Li Q, Gong F, Fang M*.Glycyrrhizin ameliorates experimental colitis through attenuating interleukin-17-producing T cell responses via regulating antigen-presenting cells. Immunol Res. 2017 ;65(3):666-680.

5. Chen X, Li L, Khan MN, Shi L, Wang Z, Zheng F, Gong F, Fang M*. HMGB1 exacerbates experimental mouse colitis by enhancing innate lymphoid cells 3 inflammatory responses via promoted IL-23 production. Innate Immunity. 2016 Nov;22(8):696-705.

6. Qin Xu, Fang Zheng, Feili Gong, and Min Fang*. Suppressor of cytokine signaling 3 (SOCS3) gene transfer prolongs the survival of murine cardiac allograft by attenuating IL-17-producing alloreactive T-cell responses. The Journal of Gene Medicine  2014；16: 66-74

7. Xia Q, Duan L, Shi L, Zheng F, Gong F, Fang M*. High-mobility group box 1 accelerates early acute allograft rejection via enhancing IL-17+ γδ T-cell response.

Transplant International 2014；27: 399-407

8．Xiong A, Duan L, Chen J, Fan Z, Zheng F, Tan Z, Gong F*, Fang M*. Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice.PLoS One. 2012; 7(10):e46230. doi: 10.1371/journal.pone.0046230.

9. Chen J, Duan L, Xiong A, Zhang H, Zheng F, Tan Z, Gong F*, Fang M*. Blockade of IL-33 ameliorates Con A-induced hepatic injury by reducing NKT cell activation and IFN-γ production in mice. J Mol Med. 2012; 90 (12):1505-1515.

10.Duan L, Chen J, Zhang H, Yang H, Zhu P, Xiong A, Xia Q, Zheng F, Tan Z, Gong F*, Fang M*. Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3⁺ regulatory T-cell responses in mice Mol Med. 2012; 18:753-761.

11. Zhu P., Duan L., Chen J., Xiong A.,Xu Q., Zhang H.，Zheng F., Tan Z., Gong F.*, Fang M.*. Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice. Human Gene Therapy 2011；22:853-864.

12. Duan L, Wang CY, Chen J, Gong Q, Zhu P, Zheng F, Tan Z, Gong F*, Fang M*. High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response. Laboratory Investigation 2011；91: 43-53.

13. Tong J, Wu WN, Kong X, Wu PF, Tian L, Du W, Fang M, Zheng F, Chen JG*, Tan Z*, Gong F*.Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells. J Immunol. 2011, 186: 3686-3692.

14. Li Liu, Lihua Duan, Min Gong, Hong Dai, Quan Gong, Fang Zheng, Zheng Tan, Cong-Yi Wang, Feili Gong, Min Fang*.  Indoleamine 2,3 dioxygenase and regulatory dendritic cells contribute to the allograft protection by infusion of donor-specific splenic stromal cells. Cellular & Molecular Immunology 2011； 8: 31-40.

15. Quan Gong, Hui Zhang, Jun-hua Li, Li-hua Duan, Shan Zhong, Xiao-ling Kong, Fang Zheng, Zheng Tan, Ping Xiong, Gang Chen, Min Fang,*, Fei-li Gong,*  High-mobility group box 1 exacerbates concanavalin A induced hepatic injury in mice. J. Mol. Med. 2010；88：1289-1298.

16．Dai H., Zhu H., Lei P., Yagita H., Liu J., Wen X., Zhou W., Gong F. , Shen G. *, Fang M.* , Programmed death-1 signaling is essential for the skin allograft protection by alternatively activated dendritic cell in fusion in mice. Transplantation 2009, 88:864-873.

17. Yu G., Dai H., Chen J., Duan L., Gong M., Liu L., Xiong P., Wang C.-Y. , Fang M.* and Gong F.*, Gene delivery of IDO prolongs cardiac allograft survival by shaping the types of T-cell responses. J. Gene Med. 2008, 10: 754-761.

18. Yu G., Fang M.*,  Gong M., Liu L., Zhong J., Feng W., Xiong P., Cong-Yi Wang C.-Y., and Gong F.*. Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells. Transplant Immunology 2008, 18: 208-219.

19. Fang M., Dai H., Yu G. Gong F-L., Gene delivery of SOCS3 protects mice from lethal endotoxic shock. Cellular & Molecular Immunology 2005，2：373-377.