劉慧，女，博士，副教授，學系副主任，湖北省藥理學會常務理事，“中國藥理學會-施維雅青年藥理學工作者獎”獲得者，2003～2005年香港大學心血管研究所訪問學者，2012～2014年香港大學李嘉誠醫學院生理學系博士後人員。長期從事藥理學的教學與科研工作，主持及參與多項國家自然科學基金、科技部科技攻關項目及省市級科研項目。

E-mail：liuh@hust.edu.cn

研究方向：心血管和代謝性疾病及腫瘤靶點研究與藥物研發

代表性論文（第一作者和*通訊作者文章）：

1.Li Z, Gao WQ, Wang P, Wang TQ, Xu WC, Zhu XY,Liu H*. Pentamethylquercetin Inhibits Hepatocellular Carcinoma Progression and Adipocytes-induced PD-L1 Expression via IFN-γ Signaling.Curr Cancer DrugTargets. 2020;20(11):868-874.

2.Li Z, Zhang C, Du JX, Zhao J, Shi MT, Jin MW,Liu H*. Adipocytes promote tumor progression and induce PD-L1 expression via TNF-α/IL-6 signaling.Cancer Cell Int. 2020 May 20; 20: 179.

3.Du JX,Wu JZ,Li Z,Zhang C,Shi MT,Zhao J, Jin MW,Liu H*. Pentamethylquercetin protects against cardiac remodeling via activation of Sestrin2.Biochem Biophys Res Commun.2019 Apr 30;512(2):412-420.

1. Han Y, Wu JZ, Shen JZ, Chen L, He T, Jin MW,Liu H*. Pentamethylquercetin induces adipose browning and exerts beneficial effects in 3T3-L1 adipocytes and high-fat diet-fed mice.Sci Rep. 2017 Apr 25;7(1):1123.

2. Liu H, Yang L, Wu HJ, Chen KH, Lin F, Li G, Sun HY, Xiao GS, Wang Y, Li GR. Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury.Sci Rep.2016 Nov 7;6:36435.

3. Liu H, Wang YJ, Yang L, Zhou M, Jin MW, Xiao GS, Wang Y, Sun HY, Li GR. Synthesis of a highly water-soluble acacetin prodrug for treating experimental atrial fibrillation in beagle dogs.Sci Rep. 2016 May 10;6:25743.

4. Liu H, Yang L, Chen KH, Sun HY, Jin MW, Xiao GS, Wang Y, Li GR. SKF-96365 blocks human ether-à-go-go-related gene potassium channels stably expressed in HEK 293 cells.Pharmacol Res. 2016 Feb;104:61-9.

5. Yang L,Liu H*, Sun HY, Li GR. Intravenous Anesthetic Propofol Inhibits Multiple Human Cardiac Potassium Channels.Anesthesiology.2015 Mar;122(3):571-84.

6. Feng M, Xiang JZ, Ming ZY, Fu Q, Ma R, Zhang QF, Dun YY,Yang L,Liu H*. Activation of epidermal growth factor receptor mediates reperfusion arrhythmias in anaesthetized rats.Cardiovasc Res. 2012;93(1): 60-68.

7. Liu H, Yang L, Jin MW, Sun HY, Huang Y, Li GR. The selective estrogen receptor modulator raloxifene inhibits cardiac delayed rectifier potassium currents and voltage-gated sodium current without QTc interval prolongation.Pharmacol Res. 2010 Nov;62(5):384-90.

8. Liu H, Sun HY, Lau CP,Li GR. Regulation of voltage-gated cardiac sodium current by epidermal growth factor receptor kinase in guinea pig ventricular myocytes.J Mol Cell Cardiol. 2007, 42(4) :760-768.

9. Liu H, Jin MW, Xiang JZ, Huang Y, Sun HY, Chiu SW, Lau CP,Li GR.Raloxifene inhibits transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes.Eur J Pharmacol. 2007, 563(1-3):61-8.

10. Liu H, Hu B, Fu H,Xiang J,Liu L. Effects of Phorbol-12,13-dibuterate on Sodium Currents and Potassium Currents in Rat Trigeminal Ganglion Neurons.Journal of Huanzhong University of Science and Technology(Med Sci), 2007, 27(1): 1-4.