胡壯麗

Email：zlhu916@hust.edu.cn

個人簡介：博士，華中科技大學同濟醫學院藥理學系副教授，武漢市藥理學會理事。1999年畢業于原同濟醫科大學臨床醫療專業，獲學士學位。2004-2005在美國俄亥俄州立大學學術交流一年，2008年獲得華中科技大學博士學位。主要從事離子通道、神經膠質細胞與情感障礙性疾病的研究。作為負責人主持國家自然科學基金五項，湖北省科技研究與開發計劃項目一項，并參與多項國家級和省級研究項目。以第一和通訊作者在Biol Psychiatry， Brain Behav Immun.，EMBO Rep.，J Neuroinflammation，Pharmacol Res.，Antioxid Redox Signal.，Glia，Neuropharmacology等雜志發表文章20餘篇。

研究方向：神經精神藥理

承擔的主要科研項目：

1.國家自然科學基金青年基金 心肌酸敏感離子通道（ASICs）：治療心肌缺血的新靶點（No. 30901804）；主持

2.國家自然科學基金面上基金 酸敏感離子通道(ASICs)：小膠質細胞炎症免疫反應的重要調節蛋白（No. 81173071）；主持

3.國家自然科學基金面上基金 小膠質細胞特有質子通道Hv1調節氧化應激在可卡因成瘾中的作用及機制研究（No. 81473199）；主持

4.國家自然科學基金面上基金 GABAB2受體輔助蛋白KCTD12影響成年海馬腦區神經發生在抑郁症中的作用及機制（No.81971266）；主持

5. 國家自然科學基金面上基金 自噬PtdIns3K複合物輔助亞基NRBF2調控成體海馬神經發生在抑郁症中的作用及機制（No.82273912）；主持

6.湖北省科技研究與開發計劃項目 作用于多靶點神經保護藥物的合作研發（2011BFA006）；主持

代表性論文：

1. Xi Chen, Qian-Qian Cui, Xiao-Hai Hu, Jian Ye, Zi-Cun Liu, Yuan-Xi Mei, Fang Wang,Zhuang-Li Hu*（并列通訊作者）and Jian-Guo Chen*.CD200 in dentate gyrus improves depressive-like behaviors of mice through enhancing hippocampal neurogenesis via alleviation of microglia hyperactivation.J Neuroinflammation.2023 Jun 30; 20(1):157.

2. Ji Wang, Hong-Sheng Chen, Hou-Hong Li, Hua-Jie Wang, Ruo-Si Zou, Xiao-Jia Lu, Jie Wang, Bin-Bin Nie, Jin-Feng Wu, Shuang Li, Bao-Ci Shan, Peng-Fei Wu, Li-Hong Long,Zhuang-Li Hu*（并列通訊作者）,Jian-Guo Chen* and Fang Wang*.Microglia-dependent excessive synaptic pruning leads to cortical underconnectivity and behavioral abnormality following chronic social defeat stress in mice.Brain Behav Immun.2023 Mar; 109:23-36.

3. Si-Long Deng#,Zhuang-Li Hu#(并列第一作者), Li Mao, Bo Gao, Qiong Yang, Fang Wang, Jian-Guo Chen. The effects of Kctd12, an auxiliary subunit of GABA_Breceptor in dentate gyrus on behavioral response to chronic social defeat stress in mice.Pharmacol Res.2021 Jan; 163: 105355.

4. Qian-Qian Cui#,Zhuang-Li Hu#(并列第一作者), Yuan-Lang Hu#, Xi Chen, Ji Wang, Li Mao, Xiao-Jia Lu, Ming Ni, Jian-Guo Chen, Fang Wang. Hippocampal CD39/ENTPD1 promotes mouse depression-like behavior through hydrolyzing extracellular ATP.EMBO Rep.2020 Apr 3; 21(4): e47857.

5. Shuang-Qi Gao, Hai Zhang, Jin-Gang He, Hui-Ling Zheng, Pei-Wei Zhang,Jun-Feng Xu, Zu-Cheng Shen, Huan-Huan Zhao, Fang Wang,Zhuang-LiHu*（并列通訊作者）andJian-Guo Chen*.Neuronal HMGB1 in nucleus accumbens regulates cocaine reward memory.Addict Biol.2020 Mar; 25(2): e12739.

6. Hai-Yun Zhou#, Jin-Gang He#,Hu Zhuang-Li#(并列第一作者), Shi-Ge Xue, Jun-Feng Xu, Qian-Qian Cui, Shuang-Qi Gao, Bin Zhou, Peng-Fei Wu, Li-Hong Long, Fang Wang, Jian-Guo Chen.A-Kinase Anchoring Protein 150-PKA Complex in the Basolateral Amygdala Contributes to Depressive-like Behaviors Induced by Chronic Restraint Stress.Biol Psychiatry. 2019 Jul 15; 86(2):131-142.

7. Ming Ni#, Jin-Gang He#, Hai-Yun Zhou, Xiao-Jia Lu, Yuan-Lang Hu, Li Mao, Fang Wang, Jian-Guo Chen,Zhuang-Li Hu*（通訊作者）. Pannexin-1 channel dysfunction in the medial prefrontal cortex mediates depressive-like behaviors induced by chronic social defeat stress and administration of mefloquine in mice.Neuropharmacology.2018 Jul 15;137:256-267.

8. Xiao-Yi Hou#,Zhuang-Li Hu#(并列第一作者), Deng-Zheng Zhang, Wei Lu, Jun Zhou, Pei-Fei Wu, Xin-Lei Guan, Qian-Qian Han, Si-Long Deng, Hai Zhang, Jian-Guo Chen*and Fang Wang*. Rapid Antidepressant Effect of Hydrogen Sulfide: Evidence for Activation of mTORC1-TrkB-AMPA Receptor Pathways.Antioxid Redox Signal.2017 Sep 10; 27(8):472-488.

9. Hui Fu#, Peng Fang#, Hai-Yun Zhou, Jun Zhou, Xiao-Wei Yu, Ming Ni, Jie-Yan Zheng, You Jin, Jian-Guo Chen, Fang Wang andZhuang-Li Hu*（通訊作者）. Acid-sensing ion channels in trigeminal ganglion neurons innervating the orofacial region contribute to orofacial inflammatory pain.Clin Exp Pharmacol Physiol.2016 Feb;43(2):193-202.

10. Xiao-Wei Yu#,Zhuang-Li Hu#(并列第一作者), Ming Ni, Peng Fang, Pei-Wei Zhang, Qing Shu, Hua Fan, Hai-Yun Zhou, Lan Ni, Ling-Qiang Zhu, Jian-Guo Chen*and Fang Wang*.Acid-sensing ion channels promote the inflammation and migration of cultured rat microglia.Glia.2015 Mar;63(3):483-96.