黃亞非，男，教授，正高職高級工程師（生物制藥類），博士生導師，“湖北省百人計劃”特聘專家、華中學者特聘教授、光谷3551人才計劃長期創新人才。于2007-2015年間先後在美國猶太人醫學中心從事博士後研究和擔任Research Associate一職，2015年任湖北省幹細胞工程技術研究中心副主任以及湖北省生命源幹細胞有限公司首席技術官和常務副總經理，2018年入職同濟醫學院88858cc永利官网病原生物學系。長期從事細胞免疫、腫瘤免疫和感染免疫相關的科研工作，近年來緻力于建立以γδT細胞和腫瘤新生抗原為基礎的個性化腫瘤免疫治療平台，并拟将此應用于惡性實體腫瘤的治療；此外，還聚焦于腫瘤免疫微環境研究。以第一作者或通訊作者發表論文20餘篇，其中一篇入選ESI高被引論文，并為斯普林格出版的圖書《Methods in Molecular Biology》撰寫有關章節。作為負責人和主要研究人員參與了973重大項目、國家重點研發項目、浙江省重點研發項目、國家自然科學基金面上項目、湖北省自然科學基金、武漢市晨光計劃、NIHR01及R21等多項研究項目。研究成果曾獲《Hypertension》雜志年度最佳論文獎和湖北省自然科學優秀學術論文一等獎，多次在國際會議上做口頭報告和大會發言。長期為《第三軍醫大學學報》、《華中科技大學大學學報（醫學版）》、《Cancer ImmunologyImmunotherapy》、《Immunobiology》《Frontiers in Immunology》、《Scandinavian Journal of Immunology》、《Frontiers in Oncology》、《Scientific Reports》和《Journal of Medical Virology》等國内外期刊審稿。

聯系方式：huangy2018@hust.edu.cn

電話：13628627928

微信：hyf13628627928

近年研究課題及基金

國家自然基金面上項目，宮頸癌來源的IL-33通過調控γδT17/Th17細胞促進抗腫瘤免疫應答的作用及機制研究，82273211，主持人，2023

國家重點研發項目，宮頸病變的精準篩查和防治研究研究，團隊骨幹，2022

橫向課題，基于免疫組庫與機器學習算法的SARS-CoV-2特異性生物标志物的開發，主持人

浙江省“尖兵”“領雁”研發攻關計劃，靶向腫瘤特異性抗原的γδT/APC-TIL細胞治療複發晚期宮頸癌的應用研究，2022C03013，第二申請人，2022

湖北省自然基金面上項目，宮頸癌細胞通過HPV E6-IL-6/STAT3軸調控腫瘤浸潤γδT細胞亞群及其功能的機制研究，2021CFB346，主持，2022

國家自然基金面上項目，肺γδT細胞通過IL-17/IL-33軸在新生期RSV感染所緻哮喘發生以及成年期RSV感染所緻哮喘急性發作中的作用及機制研究，31970865，第二申請人，2020年

國家自然基金面上項目，Vγ1/Vγ4細胞通過細胞因子網絡調控自身免疫性角膜炎發病的機制研究，81670825，主持，2017年

已發表文章

1. Gao C, Zhou Q, Liu L, Liu H, Yang Y, Qu S, He S,Huang Y*, He X*, Wang H*. Stratifcation by Mutational Landscape Reveals Diferential Immune Infltration and Predicts the Recurrence and Clinical Outcome of Cervical Cancer.Phenomics. 2025. March 20. doi: 10.1007/s43657-024-00158-w.(通訊作者)

2. Wu M, Liu J, Liu L, Yang Y, Liu H, Yu L, Zeng H, Yuan S, Xu R, Liu H, Jiang H, Qu S, Wang L, Chen Y, Wang J, Zhang Y, He S, Feng L, Han J, Zeng W*, Wang H*,Huang Y*. Autologous peripheral Vγ9Vδ2 T cell synergizes with αβ T cell through antigen presentation and BTN3A1 blockade in immunotherapy of cervical cancer.Adv Sci.2025 March 17. doi: 10.1002/advs.202401230.(通訊作者)

3. Liu J, Wu M, Yang Y, Mei X, Wang L, Wang J, Wang Z, He S, Liu H, Jiang H, Qu S, Zhang Y, Chen Y, Tian X,Huang Y*, Wang H*. BTN3A1 expressed in cervical cancer cells promotesVγ9Vδ2 Tcells exhaustion through upregulating transcription factors NR4A2/3 downstream of TCR signaling.Cell Commun Signal.2024 Sep 28;22(1):459. doi: 10.1186/s12964-024-01834-0.(通訊作者)

4. Liu H, Wu M, Wang Q, Gao L, Jiang H, Shi K, Lin Y, Zhou J, Huang J, Qu S, Zhang Y, Zheng F,Huang Y*, Han J*. IL-33 released during challenge phase regulates allergic asthma in an age-dependent way.Cell Mol Immunol. 2024 Aug 12. doi: 10.1038/s41423-024-01205-2. Online ahead of print.(通訊作者)

5. Fang J, Lei J, He B, Wu Y, Chen P, Sun Z, Wu N,Huang Y,Wei P, Yin L*, Chen Y*.Decoding the transcriptional heterogeneity, differentiation lineage, clinical significance in tissue-resident memory CD8 T cell of the small intestine by single-cell analysis.J Transl Med. 2024 Feb 25;22(1):203. doi: 10.1186/s12967-024-04978-2.（共同作者）

   2.Mei X, Xiong J, Liu J, Huang A, Zhu D*,Huang Y*, Wang H*.DHCR7 promotes lymph node metastasis in cervical cancer through cholesterol reprogramming-mediated activation of the KANK4/PI3K/AKT axis and VEGF-C secretion.Cancer Lett. 2024 Mar 1;584:216609. doi: 10.1016/j.canlet.2024.216609. Epub 2024 Jan 9.（通訊作者）

   3.Liu L, Wu M, Huang A, Gao C, Yang Y, Liu H, Jiang H, Yu L,Huang Y*, Wang H*.Establishment of a high-fidelity patient-derived xenograft model for cervical cancer enables the evaluation of patient's response to conventional and novel therapies.J Transl Med.2023 Sep 9;21(1):611. doi: 10.1186/s12967-023-04444-5.（通訊作者）

   4.Li X, Ren C, Huang A, Zhao Y, Wang L, Shen H, Gao C, Chen B, Zhu T, Xiong J, Zhu D,Huang Y, Ding J, Yuan Z, Ding W*, Wang H*.PIBF1 regulates multiple gene expression via impeding long-range chromatin interaction to drive the malignant transformation of HPV16 integration epithelial cells.J Adv Res. 2024 Mar;57:163-180. doi: 10.1016/j.jare.2023.04.015. Epub 2023 May 13.（共同作者）

   5.Zha Y, Liu H, Lin X, Yu L, Gao P, Li Y, Wu M, Gong X, Bian X, Kang Q, Zhi P, Dang X, Wang J, Feng L, Qiao F,Huang Y*, Zeng W*.Immune Deviation in the Decidua During Term and Preterm Labor.Front Immunol.2022 Jun 10;13:877314. doi: 10.3389/fimmu.2022.877314. eCollection 2022.（通訊作者）

   6.Liu H, Xu R, Gao C, Zhu T, Liu L, Yang Y, Zeng H,Huang Y^#and Wang H^#. Metabolic Molecule PLA2G2D is a Potential Prognostic Biomarker Correlating with Immune Cell Infiltration and the Expression of Immune Checkpoint Genes in Cervical Squamous Cell Carcinoma.Front Oncol. Oct 18;11:755668. doi: 10.3389/fonc.2021.755668.（通訊作者）

   7.Gao L, Wu M, Liu H, He M, Jiang H, Shang R, Wang Q, Song Z,Huang Y^#, Han J^#. Neonatal LPS Administered Before Sensitization Reduced the Number of Inflammatory Monocytes and Abrogated the Development of OVA-Induced Th2 Allergic Airway Inflammation.Front Immunol. 2021 Sep 22;12:725906. doi: 10.3389/fimmu.2021.725906.（通訊作者）

   8.Qiu L, Zhang J,Huang Y, Chen G, Chen Z, Ming C, Lu X, Gong N. Long-Term Clinical and Immunological Impact of Severe COVID-19 on a Living Kidney Transplant Recipient - A Case Report.Front Immunol.2021 Sep 8;12:741765. doi: 10.3389/fimmu.2021.741765.（共同作者）

   9.Liu Y, Liu B, Wu Y, Zhang Y, San D, Chen Y, Zhou Y, Yu L, Zeng H, Zhou Y, Yang H, Yin L^#,Huang Y^#. Biomarkers and Immune Repertoire Metrics Identified by Peripheral Blood Transcriptomic Sequencing Reveal the Pathogenesis of COVID-19.Front Immunol. Accepted 2021 Aug 24; 12:677025. doi: 10.3389/fimmu.2021.677025.（通訊作者）

   10.Yu L,Zhang Y,Xiong J,Liu J,Zha Y,Kang Q,Zhi P,Wang Q,Wang H,Zeng W^#,Huang Y^#. Activated γδ T cells with higher CD107a expression and inflammatory potential during early pregnancy in patients with recurrent spontaneous abortion.Front Immunol. 2021 Aug 17;12:724662. doi: 10.3389/fimmu.2021.724662. eCollection 2021.（通訊作者）

   11.Jiang H*, Li Z*#, Yu L, Zhang Y, Zhou L, Wu J, Yuan J, Han M, Xu T, He J, Wang S, Yu C, Pan S, Wu M, Liu H, Zeng H, Song Z, Wang Q, Qu S, Zhang J,Huang Y^#, Han J^#. Immune Phenotyping of Patients With Acute Vogt-Koyanagi-Harada Syndrome Before and After Glucocorticoids Therapy.Front Immunol.2021 Apr 28;12:659150. doi: 10.3389/fimmu.2021.659150. eCollection 2021.（共同通訊作者）

   12.Zha Y, Chen G, Gong X, Wu YY, Lin XG, Wu JL,Huang YF, Li YQ, Zhang Y, Deng DR, Chen SH, Qiao FY, Feng L, Zeng WJ, Li KZ, Liu HY. Coronavirus disease 2019 in pregnant and non-pregnant women: a retrospective study.Chin Med J (Engl). 2021 Feb 25;134(10):1218-1220. doi: 10.1097/CM9.0000000000001396.（共同作者）

   13.Yang G, Tan Z, Zhou L, Yang M, Peng L, Liu J, Cai J, Yang R, Han J,Huang Y^#, He S^#. Effects of Angiotensin II Receptor Blockers and ACE (Angiotensin-Converting Enzyme) Inhibitors on Virus Infection, Inflammatory Status, and Clinical Outcomes in Patients With COVID-19 and Hypertension: A Single-Center Retrospective Study.Hypertension. 2020 Jul;76(1):51-58.doi: 10.1161/HYPERTENSIONAHA.120.15143.（通訊作者；編委點評并被評為雜志2020年度最佳論文；入選ESI高被引論文）

   14.Liu B, Han J, Cheng X, Yu L, Zhang L, Wang W, Ni L, Wei C,Huang Y^#, Cheng Z^#. Reduced numbers of T cells and B cells correlates with persistent SARS-CoV-2 presence in non-severe COVID-19 patients.Sci Rep. 2020 Oct 19;10(1):17718. doi: 10.1038/s41598-020-73955-8.（通訊作者）

   15.Qiu L, Jiao R, Zhang A, Chen X, Ning Q, Fang F, Zeng F, Tian N, Zhang Y,Huang Y, Sun Z, Dhuromsingh M, Li H, Li Y, Xu R, Chen Y, Luo X. A Case of Critically Ill Infant of Coronavirus Disease 2019 With Persistent Reduction of T Lymphocytes.Pediatr Infect Dis J. 2020 Jul;39(7):e87-e90. doi: 10.1097/INF.0000000000002720.（共同作者）

   16.Wu M, Gao L, He M, Liu H, Jiang H, Shi K, Shang R, Liu B, Gao S, Chen H, Gong F, Gelfand EW,Huang Y, Han J. Plasmacytoid dendritic cell deficiency in neonates enhances allergic airway inflammation via reduced production of IFN-α.Cell Mol Immunol. 2020 May;17(5):519-532. doi: 10.1038/s41423-019-0333-y. Epub 2019 Dec 18.（共同作者）

   17.Phalke SP,Huang Y,Rubtsova K, Getahun A, Sun D, Reinhardt RL, O'Brien RL, Born WK. γδ T cells shape memory-phenotype αβ T cell populations in non-immunized mice.PLoS One. 2019 Jun 25;14(6):e0218827.doi: 10.1371/journal.pone.0218827.（共同作者）

   18.Born WK,Huang Y,Reinhardt RL, Huang H, Sun D, O'Brien RL. γδT cellsand B cells.Adv Immunol.2017, 134:1-45. doi: 10.1016/bs.ai.2017.01.002.（受邀綜述，共同作者）

   19.Born WK,Huang Y,Zeng W,O'Brien RL. A Special Connection Between γδT cellsand NaturalAntibodies? Arch ImmunolTher Exp. 2016:Dec;64(6):455-462. doi: 10.1007/s00005-016-0403-0.（受邀綜述，共同作者）

   20.Huang Y, Heiser RA, Detanico T, Getahun A, Kirchenbaum A, Casper TL, Carding SR, Ikuta K, Huang H, Cambier JC, Wysocki LJ, O'Brien RL, Born WK. γδ T Cells Shape PreImmune Peripheral B Cell Populations.J Immunol. 2016,196(1):217-31. doi: 10.4049/jimmunol.1501064.（第一作者）

   21.Huang Y,Yang Z,Huang C, O'Brien RL, Born WK. γδTCell–Dependent Regulatory T Cells Prevent the Development of Autoimmune Keratitis.JImmunol.2015,195: 5572-5581.（第一作者）

   22.HuangY*,YangZ,McGowanJ,HuangH,O'BrienRL,BornWK.RegulationofIgEresponsesbyγδTcells.CurrentAllergy&AsthmaReports.2015,15(4):549.（第一作者和通訊作者；受邀綜述）

   23.HuangY,HeiserRA,DetanicoT,GetahunA,KirchenbaumA,CasperTL,AydintugMK,CardingSR, IkutaK,HuangH,CambierJC,WysockiLJ,O'BrienRL,BornWK.γδTCellsAffectIL-4ProductionandBcellTolerance.ProceedingsoftheNationalAcademyofScience.2015,112(1):E39-48.（第一作者）

   24.HuangY,AydintugMK,HuangH,O'BrienRL,BornWK.Antigen-specificregulationof IgEantibodiesbynon-antigen-specificγδTcells.JImmunol.2013,190(3):913-21.（第一作者）

   25.Roark CL,Huang Y,Jin N, Aydintug MK, Casper T, Sun D, Born WK, O'Brien RL. A canonical Vγ4Vδ4+γδ T cell population with distinct stimulation requirements which promotes the Th17 response.Immunol Res. 2013, 55(1-3):217-230.（共同作者）

   26.O'Brien RL, Chain JL, Aydintug MK, Bohrer-Kunter D,Huang Y, Hardy IR, Cambier JC, Lahmers K, Nuhsbaum T, Davidson R, Sun D, Born WK. αβ TCR⁺T cells, but not B cells, promote autoimmune keratitis in B10 mice lacking γδ T cells.Invest OphthalmolVis Sci. 2012, 53(1):301-8.（共同作者）

   27.Born WK, Zhang L, Nakayama M, Jin N, Chain JL,Huang Y, Aydintug MK, O'Brien RL. Peptide Antigens for γδ T-cells.Cell Mol Life Sci. 2011, 68(14):2335-43. Review.（共同作者）

   28.O’Brien RL, Jin N,Huang Y, Aydintug MK, Roark CL, and Born, WK. Characteristics of IL-17-producing γδ T cells.Immunity.2010, 32(1):1. Letter to the Editor.（共同作者; letter to editor）

   29.Born W,Huang Y, Jin N, HuangH, and O’Brien RL. Balanced Approach of Gamma delta T-cells to Type 2 Immunity.Immunology and Cell Biology. 2010, 88(3):269-74.（共同作者）

   30.Huang Y, Jin N, Roark CL, Aydintug MK, Wands JM, Huang H, O'Brien RL, Born WK. The Influence of IgE-Enhancing and IgE-Suppressive Gammadelta T-cells Changes withExposure to Inhaled Ovalbumin.J Immunol. 2009, 183:849-855.（第一作者；作為該期雜志重點推介）

   31.Jin N, Roark CL, Miyahara N, Taube C, Aydintug MK, Wands JM,Huang Y,Hahn YS, Gelfand EW, O'Brien RL, Born WK. Allergic Airway Hyperresponsiveness-Enhancing Gammadelta T-cells Develop in Normal Untreated Mice and Fail to Produce IL-4/13,Unlike Th2 and NKT Cells.J Immunol. 2009, 182(4):2002-10.（共同作者）

   32.Cheng L, Cui Y, Shao H, Han G, Zhu L,Huang Y, O'Brien RL, Born WK, Kaplan HJ, Sun D. Mouse Gammadelta T-cells are Capable of Expressing MHC Class II Molecules,and of Functioning as Antigen-Presenting Cells.J Neuroimmunol. 2008, 203(1):3-11.（共同作者）

   33.Han J, Zhong J, Wei W, Wang Y,Huang Y, Yang P, Purohit S, Dong Z, Wang MH, She JX, Gong F, Stern DM, Wang CY. Extracellular High-Mobility Group Box 1 acts as an Innate Immune Mediator to Enhance Autoimmune Progression and Diabetes Onset inNOD Mice.Diabetes. 2008, 57(8):2118-27.（共同作者）

   34.Huang Y, Yin H, Han J, Huang B, Xu J, Zheng F, Tan Z, Fang M, Rui L, Chen D, Wang S, Zheng X, Wang CY, Gong F. Extracellular hmgb1 Functions as an InnateImmune-Mediator Implicated in Murine Cardiac Allograft Acute Rejection.Am J Transplant. 2007, 7(4):799-808.（第一作者）

   35.Huang BJ, Yin H,Huang YF, Xu JF, Xiong P, Feng W, Zheng F, Xu Y, Fang M, Gong FL. Gene Therapy Using Adenoviral Vector Encoding 4-1BBIg Gene Significantly ProlongedMurine Cardiac Allograft Survival.Transpl Immunol. 2006, 16(2):88-94.（共同作者）

   36.Yin H, Huang BJ, Yang H,Huang YF, Xiong P, Zheng F, Chen XP, Chen YF, Gong FL. Pretreatment With Soluble ST2 Reduces Warm Hepatic Ischemia/Reperfusion Injury.Biochem Biophys Res Commun. 2006, 29;351(4):940-6.（共同作者）

   37.Zhang Z, Jia L, Hou L, Xiong P, Wu X, Wang X,Huang Y, Ke H, Chang C, Cui S, GongF. Analysis of TAP1 and TAP2 Polymorphism of Mother-Infant in Chinese Patients with Pre-Eclampsia.Cell Mol Immunol.2005, 2(2):141-4.（共同作者）

   38.Huang YF, Wang W, Han JY, Wu XW, Zhang ST, Liu CJ, Hu QG, Xiong P, Hamvas RM, Wood N, Gong FL, Bittles AH. Increased Frequency of the Mannose-Binding Lectin LX Haplotype in Chinese Systemic Lupus Erythematosus Patients.IntJ Immunogenet. 2003,30:121-124.（第一作者）

    

編撰書籍:

1.黃亞非“第三章：補體系統”《醫學免疫學》第二版（研究生教材，龔非力主編）科學出版社

2.黃亞非“第十四章：超敏反應”《醫學免疫學》第二版（研究生教材，龔非力主編）科學出版社

3.RebeccaL.O’Brien,PhilipL.Simonian,YafeiHuang,ChristinaL.Roark,NiyunJin,M.KemalAydintug,JenniferL.Chain,AndrewP.Fontenot,andWilliK.Born.“Chapter28:IL-17-producingTcellsinAutoimmunedisease”inTH17CellsinHealthandDisease.Springer:NewYork.2011.513-24

4.Wanjiang Zeng,RebeccaL.O’Brien,WilliK.Born, andYafei Huang*. “Chapter 12: Characterization of Mouse γδ T Cell Subsets in the Setting of Type-2 Immunity” inType 2 Immunity.Methods in Molecular Biology: Methods and Protocols .Springer:NewYork. 2018.