阮林浩 華中科技大學同濟醫學院教授，博導

專業方向：漸凍人症的細胞分子機理；線粒體在蛋白穩态中的新功能

個人簡介：2011年畢業于華中科技大學生命科學與技術學院生物技術專業，獲理學和管理學雙學士學位。2014年畢業于中國科學院大學生物物理研究所，獲生物工程專業碩士學位（合作導師吳瑛教授）。2021年畢業于約翰霍普金斯大學醫學院，獲細胞生物學方向理學博士學位（合作導師Rong Li）。2021至2024年，于約翰霍普金斯醫學院腦科學研究所從事博士後研究（合作導師Jeffrey Rothstein）。入選國家高層次人才項目并于2024年入職88858cc永利官网生理學系。主要研究漸凍人症的細胞分子機制，以及衰老中的線粒體損傷和蛋白穩态調節的關系。回國前曾主持美國心髒協會、陳-紮克伯格基金會的研究項目。近年來以第一、共同第一作者在Nature, Science Advances, eLife, Journal of Cell Science, Annual Review Biophysics等重要期刊發表論文。

實驗室主要采用由人類多能幹細胞衍生的神經元、小鼠和酵母細胞模型，運用跨學科方法融合細胞生物學、分子生物學、神經生物學和生物化學，應用超分辨率成像、CRISPR基因編輯、全基因組篩選、流式細胞分選及遺傳操作等技術，深入研究衰老及神經退行性疾病的細胞分子基礎。同時，我們也緻力于開發檢測漸凍症的新型試劑盒和治療方法。

實驗室網站： ruanlinhaolab.com

聯系方式：ruanlinhao@hust.edu.cn

發表的工作： https://pubmed.ncbi.nlm.nih.gov/?term=linhao+ruan

Ruan Linhao, Professor and Ph.D. advisor at Tongji Medical College, Huazhong University of Science and Technology.

Research Focus: Cellular and molecular mechanisms of amyotrophic lateral sclerosis (ALS); mitochondrial functions in protein homeostasis.

Biography: In 2011, Ruan Linhao graduated from the College of Life Science and Technology at Huazhong University of Science and Technology with dual bachelor's degrees in Biotechnology, Science, and Management. He completed his Master's degree in Bioengineering in 2014 at the Institute of Biophysics, University of Chinese Academy of Sciences (Advisor: Professor Jane Wu). In 2021, he received his Ph.D. in Cell Biology from Johns Hopkins University School of Medicine (Advisor: Rong Li). From 2021 to 2024, he conducted postdoctoral research at the Brain Science Institute of Johns Hopkins School of Medicine (Advisor: Jeffrey Rothstein). He joined the Department of Physiology at the School of Basic Medicine in 2024. His main research interests include the cellular and molecular mechanisms of ALS and the relationship between mitochondrial damage and protein homeostasis regulation in aging. Prior to returning to China, he led research projects funded by the American Heart Association and the Chan Zuckerberg Initiative. In recent years, he has published papers as the first or co-first author in prestigious journals such as Nature, Science Advances, eLife, Journal of Cell Science, and Annual Review of Biophysics.

His laboratory primarily utilizes models of human pluripotent stem cell-derived neurons, mice, and yeast cells, integrating interdisciplinary approaches from cell biology, molecular biology, neurobiology, and biochemistry. They employ techniques such as super-resolution imaging, CRISPR gene editing, whole-genome screening, flow cytometry, and genetic manipulation to understand the cellular and molecular underlying aging and neurodegenerative diseases. Additionally, his team is dedicated to developing new diagnostic kits and treatments for ALS.