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劉丹 湖北省武漢市航空路13号同濟醫學院醫學遺傳系 郵件：liudan_echo@mail.hust.edu.cn 手機：15926309921 QQ：496013260 |
個人簡介
劉丹，講師，碩士生導師，湖北省優秀博士論文獲得者。研究方向：表觀遺傳學在神經精神疾病中的作用。承擔國家自然科學基金青年項目一項。目前發表SCI論文16篇，其中包括Neuron, J Neurosci, Cell Death & Differ, Mol Neurobiol等國際知名雜志。
教育經曆
2006/9-2011/6，華中科技大學，88858cc永利官网病理生理學，博士
2002/9-2006/6，華中科技大學，藥學，本科
留學經曆
2012/10-2013/10，美國路易斯安娜州立大學，健康醫學中心神經科學中心，博士後
工作經曆
2012/3-至今，華中科技大學，88858cc永利官网，講師
承擔教學工作情況
承擔五年制臨床醫學、法醫和醫學影像學及四年制檢驗班等本科生的醫學遺學的理論及實驗課的教學；承擔研究生的醫學遺傳學、高級醫學遺傳學及醫學遺傳學進展等課程的教學。
研究方向
主要從事阿爾茨海默病（Alzheimer’s disease, AD）發病的分子機制及防治措施的研究。該病是最常見的一類老年癡呆症，以進行性認識功能障礙為特征，嚴重影響老年人群的生活質量，同時對整個社會也帶來極大的負擔。然而，目前對于該病的發病機制、預防及治療措施尚不清楚。微小RNA是一類高度保守的非編碼RNA，其主要在轉錄/轉錄後水平對基因的表達進行調控。近年來的研究表明microRNA的失調對AD的發病進程起重要作用，所以本課題組的主要研究方向為microRNA在AD發病中的作用與機制研究。
主持科研項目
華中科技大學自主創新基金，編号2012QN134，糖原合酶激酶3 在阿爾茨海默病突觸病變中的作用和機制，2012.05-2013.12，金額5萬，負責人。（已結題）
國家自然科學基金，編号31201011，糖原合酶激酶3 對樹突棘可塑性的調控作用和機制及其應用，2013.01-2015.12，金額23萬，負責人。（已結題）
華中科技大學自主創新基金，編号2015QN143，褪黑素受體2 對突觸可塑性的調控作用及機制，2015.01-2016.12，金額5萬，負責人。（在研）
發表論文
Liu, D; Wei, N; Man, H-Y; Lu, Y(*); Zhu, L-Q(*); Wang, J-Z(*),The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling., Cell Death and Differentiation.
Wei, Na; Zhu, Ling-Qiang; Liu, Dan(*),ATF4: a Novel Potential Therapeutic Target for Alzheimer's Disease., Molecular Neurobiology.
Wang, Xiang; Wang, Liang-Ping; Tang, Hui; Shan, Wan-Ying; Wang, Xiong; Liu, Dan(*); Wu, Yuan-Yuan; Tian, Qing; Wang, Jian-Zhi(*); Zhu, Ling-Qiang(*),Acetyl-L-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation, Neuropharmacology, 76卷, pp 80-87, 2014/1.
Tang, Hui(#); Shen, Na(#); Jin, Huijuan(#); Liu, Dan(*); Miao, Xiaoping(*); Zhu, Ling-Qiang(*),GSK-3 beta Polymorphism Discriminates Bipolar Disorder and Schizophrenia: A Systematic Meta-Analysis, Molecular Neurobiology, 48(3), pp 404-411, 2013/12.
Tan, Lu; Wang, Xiong; Ni, Zhong-Fei; Zhu, Xiuming; Wu, Wei; Zhu, Ling-Qiang; Liu, Dan(*),A Systematic Analysis of Genomic Changes in Tg2576 Mice, Molecular Neurobiology, 47(3), pp 883-891, 2013/6.
Wang Xiong(#); Wang Zhi-Hao(#); Wu Yuan-Yuan; Tang Hui; Tan Lu; Wang Xiang; Gao Xinya; Xiong Yansi; Liu Dan(*); Wang Jian-Zhi; Zhu Ling-Qiang(*),Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathway., Molecular Neurobiology, 47(1), pp 373-381, 2013/2/20.
Yang, Ying(#); Shu, Xiaogang(#); Liu, Dan(#); Shang, You; Wu, Yan; Pei, Lei; Xu, Xin; Tian, Qing; Zhang, Jian; Qian, Kun; Wang, Ya-Xian; Petralia, Ronald S.; Tu, Weihong; Zhu, Ling-Qiang(*); Wang, Jian-Zhi(*); Lu, Youming(*),EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation, Neuron, 73(4), pp 774-788, 2012/2/23.
Liu, Dan; Zheng, Hong-Yun; Luo, Zheng-Zhao; Wang, Qun; Zhu, Ling-Qiang,Culture of newborn monkey liver epithelial progenitor cells in chemical defined serum-free medium, In Vitro Cellular & Developmental Biology-Animal, 46(8), pp 702-707, 2010/9.
Zhu, Ling-Qiang(#); Liu, Dan(#); Hu, Juan; Cheng, Jin; Wang, Shao-Hui; Wang, Qun; Wang, Fang; Chen, Jian-Guo; Wang, Jian-Zhi(*),GSK-3 beta Inhibits Presynaptic Vesicle Exocytosis by Phosphorylating P/Q-Type Calcium Channel and Interrupting SNARE Complex Formation, Journal of Neuroscience, 30(10), pp 3624-3633, 2010/3/10.
Zhu, Ling-Qiang(#); Zheng, Hong-Yun(#); Peng, Cai-Xia; Liu, Dan; Li, Hong-Lian; Wang, Qun; Wang, Jian-Zhi,Protein Phosphatase 2A Facilitates Axonogenesis by Dephosphorylating CRMP2, Journal of Neuroscience, 30(10), pp 3839-3848, 2010/3/10.
Zhu, Ling-Qiang; Wang, Shao-Hui; Liu, Dan; Yin, Yang-Yang; Tian, Qing; Wang, Xiao-Chuan; Wang, Qun; Chen, Jian-Guo; Wang, Jian-Zhi,Activation of glycogen synthase kinase-3 inhibits LongTerm Potentiation with synapse-associated impairments, Journal of Neuroscience, 27(45), pp 12211-12220, 2007/11/7.
Zhou, Peng, Chen, Zhuo, Zhao, Ning, Liu, Dan, Guo, Zi-Yuan, Tan, Lu, Hu, Juan, Wang, Qun, Wang, Jian-Zhi, *Zhu, Ling-Qiang, 2011,Acetyl-L-Carnitine Attenuates Homocysteine-Induced Alzheimer-Like Histopathological and Behavioral Abnormalities, 14(6), pp 669-679(2011, SCI, IF=4.2250(2010))
Peng, Cai-Xia(#); Hu, Juan(#); Liu, Dan; Hong, Xiao-Ping; Wu, Yuan-Yuan; Zhu, Ling-Qiang(*); Wang, Jian-Zhi(*),Disease-modified glycogen synthase kinase-3 beta intervention by melatonin arrests the pathology and memory deficits in an Alzheimer's animal model, Neurobiology of Aging, 34(6), pp 1555-1563, 2013/6.
Wu, Yuan-Yuan; Wang, Xiong; Tan, Lu; Liu, Dan; Liu, Xing-Hua; Wang, Qun; Wang, Jian-Zhi(*); Zhu, Ling-Qiang(*),Lithium Attenuates Scopolamine-Induced Memory Deficits with Inhibition of GSK-3 beta and Preservation of Postsynaptic Components, Journal of Alzheimer's Disease, 37(3), pp 515-527, 2013.
Wang, Shao-Hui; Liao, Xiao-Mei; Liu, Dan; Hu, Juan; Yin, Yang-Yang; Wang, Jian-Zhi(*); Zhu, Ling-Qiang(*),NGF promotes long-term memory formation by activating poly(ADP-ribose) polymerase-1, Neuropharmacology, 63(6), pp 1085-1092, 2012/11.
Juan Hu; Xiang Wang; Dan Liu; Qun Wang; Ling-Qiang Zhu(*),Olfactory deficits induce neurofilament hyperphosphorylation, Neuroscience Letters, 506(2), pp 180-183, 2012 1月.
Kai Liao; Dan Liu; Ling-Qiang Zhu(*),Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex., Neuroscience Letters, 507(1), pp 22-26, 2012 1月.
Hu, Juan; Huang, He-Zhou; Wang, Xiang; Xie, Ao-Ji; Wang, Xiong; Liu, Dan; *Wang, Jian-Zhi; *Zhu, Ling-Qiang,Activation of Glycogen Synthase Kinase-3 Mediates the Olfactory Deficit-Induced Hippocampal Impairments., Molecular Neurobiology, 52(3), pp 1601-1617, 2015/12.
Xiong, Yan-Si; Liu, Fang-Fang; Liu, Dan; Huang, He-Zhou; Wei, Na; Tan, Lu; Chen, Jian-Guo; Man, Heng-Ye; Gong, Cheng-Xin; Lu, Youming; Wang, Jian-Zhi; Zhu, Ling-Qiang,Opposite effects of two estrogen receptors on tau phosphorylation through disparate effects on the miR-218/PTPA pathway., Aging Cell, 14(5), pp 867-877, 2015/10.
Li, Ke; Liu, Fang-Fang; He, Chun-Xue; Huang, He-Zhou; Xie, Ao-Ji; Hu, Fan; Liu, Dan; Wang, Jian-Zhi; Zhu, Ling-Qiang,Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5., Molecular Neurobiology, 2014/12/3.
Chen, Yaomin(#); Wang, Bin(#); Liu, Dan; Li, Jing Jing; Xue, Yueqiang; Sakata, Kazuko; Zhu, Ling-qiang; Heldt, Scott A.; Xu, Huaxi; Liao, Francesca-Fang(*),Hsp90 Chaperone Inhibitor 17-AAG Attenuates A beta-Induced Synaptic Toxicity and Memory Impairment, Journal of Neuroscience, 34(7), pp 2464-2470, 2014/2/12.
專利
朱鈴強；高鑫雅；劉丹；王志昊；馬禹佳；毛璐,番茄紅素在制備防治老年癡呆藥物中的應用
朱鈴強；王雄；劉丹；譚璐；黃和周,一種用于預防和治療老年性癡呆的藥物及制劑, 2014/7/30, 湖北, CN201410151210.0.
朱鈴強；譚璐；周鵬；王雄；劉丹,一種防治老年癡呆的藥物, 2014/5/28, 湖北, CN201410082815.9.
獎勵與榮譽
2010年9月獲教育部首屆“博士研究生學術新人獎”；
2012年12月獲湖北省優秀博士論文獎；
2015年7月獲華中科技大學“學術新人獎”
