組織與胚胎學系
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彭挺

作者: 時間:2024-12-10 點擊量:

 

 

彭挺,博士,碩士生導師,華中科技大學同濟醫學院組織學與胚胎學系副教授,華中科技大學同濟醫學院附屬中學科學副校長,88858cc永利官网形态學實驗中心副主任。武漢大學生命科學院本科,學士;華中科技大學同濟醫學院研究生,碩士、博士。湖北省解剖學會理事,湖北省細胞生物學會理事,中國解剖協會發育生物學分會青年委員。湖北省名師工作室團隊成員,從事組織胚胎學、發育生物學、細胞生物學教學工作,國家級線下一流課程《組織學與胚胎學》,人衛慕課《組織學與胚胎學》、國家精品資源共享課程、國家精品課程、國家雙語教學示範課程建設項目的主要成員和視頻主講教師。國家十二五規劃教材《組織學與胚胎學第3版》編委,全國高等學校八年制及“5+3”一體化臨床醫學專業第四輪規劃教材《組織學與胚胎學第四版》數字編委。《中國組織化學與細胞化學雜志》編委,圖像編輯;《解剖學報》青年編委。

主要研究方向:神經退行性疾病發病機制、神經發育,及腫瘤細胞生物學。重點關注亨廷頓舞蹈病的發病機制和治療,在突變亨廷頓蛋白異常聚集、泛素化修飾降解、細胞毒性産生等方面取得重要進展。

曾獲首屆華中科技大學十大魅力教師,華中科技大學青年教師教學競賽一等獎,湖北省首屆青年教師教學競賽二等獎,指導學生獲首屆和第三屆全國大學生基礎醫學實驗設計大賽一等獎。主持國家自然科學基金面上項目1項,參與4項;主持華中科技大學自主創新研究基金2項,重點項目1項,省級科研教改項目2項。發表SCI論文13篇,其中以通訊作者身份發表5篇。

主要論文:

  1. Liu, J., Tan, X., Li, L., Cao, L., Zhou, Y., Li, H., and Peng, T. (2024) Protein expression of nucleolar protein 12 in the retina and its implication in protection of retina from UV irradiation damage. Cell death discovery 10, 130

  2. Xiang, D. D., Liu, J. T., Zhong, Z. B., Xiong, Y., Kong, H. Y., Yu, H. J., Peng, T., and Huang, J. Q. (2023) MicroRNA-29a-3p Prevents Drug-Induced Acute Liver Failure through Inflammation-Related Pyroptosis Inhibition. Curr Med Sci 43, 456-468

  3. Du, A., Li, L., Jiao, Z., Zhu, G., Peng, T., and Li, H. (2021) Protein expression pattern of calcium-responsive transactivator in early postnatal and adult testes. Histochemistry and cell biology 155, 491-502

  4. Zhu, G., Peng, T., Peng, C., and Li, H. (2019) Chronic lead exposure decreases the expression of Huntingtin-associated protein 1 (HAP1) through Repressor element-1 silencing transcription (REST). Toxicol Lett 306, 1-10

  5. Luo, H., Cao, L., Liang, X., Du, A., Peng, T., and Li, H. (2018) Herp Promotes Degradation of Mutant Huntingtin: Involvement of the Proteasome and Molecular Chaperones. Mol Neurobiol 55, 7652-7668

  6. Niu, L., Ye, C., Sun, Y., Peng, T., Yang, S., Wang, W., and Li, H. (2018) Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington's disease. Cell & bioscience 8, 41

  7. Liu, X., Peng, T., and Li, H. (2018) Using Huntingtin Knock-In Minipigs to Fill the Gap Between Mouse Models and Patients with Huntington's Disease. Neurosci Bull 34, 870-872

  8. Lin, L., Jin, Z., Tan, H., Xu, Q., Peng, T., and Li, H. (2016) Atypical ubiquitination by E3 ligase WWP1 inhibits the proteasome-mediated degradation of mutant huntingtin. Brain Res 1643, 103-112

  9. Fang, F., Peng, T., Yang, S., Wang, W., Zhang, Y., and Li, H. (2016) Lycium barbarum polysaccharide attenuates the cytotoxicity of mutant huntingtin and increases the activity of AKT. Int J Dev Neurosci 52, 66-74

  10. Jiang, Y., Lv, H., Liao, M., Xu, X., Huang, S., Tan, H., Peng, T., Zhang, Y., and Li, H. (2012) GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins. Neurosci Lett 516, 182-187

  11. Wang, Z., Peng, T., Wu, H., He, J., and Li, H. (2015) HAP1 helps to regulate actin-based transport of insulin-containing granules in pancreatic beta cells. Histochemistry and cell biology 144, 39-48

  12. Zhang, T., Dong, K., Liang, W., Xu, D., Xia, H., Geng, J., Najafov, A., Liu, M., Li, Y., Han, X., Xiao, J., Jin, Z., Peng, T., Gao, Y., Cai, Y., Qi, C., Zhang, Q., Sun, A., Lipinski, M., Zhu, H., Xiong, Y., Pandolfi, P. P., Li, H., Yu, Q., and Yuan, J. (2015) G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L. Elife 4, e06734

  13. Liao, M., Chen, X., Han, J., Yang, S., Peng, T., and Li, H. (2010) Selective expression of Huntingtin-associated protein 1 in beta-cells of the rat pancreatic islets. J Histochem Cytochem 58, 255-263

 

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