張斌       1975年出生，理學博士。1996年和1999年于武漢大學分别獲得病毒與分子生物學學士和碩士學位，2002年于北京協和醫科大學獲得生化與分子生物學博士學位。2003年赴美國University of Alabama at Birmingham 進行博士後研究工作，2004年轉入Medical College of Georgia。2009年轉為Assistant Research Scientist。在美期間主要從事神經肌肉接頭形成發育的分子機制，以及神經肌肉接頭相關的神經疾病的發病機理研究，并在Neuron、Journal of Neuroscience、Journal of Clinical Investigation、Archive of Neurology等國際學術刊物上發表多篇論文，研究工作被Nature、Science、Neuron、Nature Reviews Neuroscience等學術刊物引用，其中對于LRP4蛋白在神經肌肉接頭形成中重要作用的研究成果已被Principles of Neural Science (Kandel et al., 5th edition)， Fundamental Neuroscience (Squire et al., 4th edition) 等權威神經生物學教科書收錄。2013年12月回國工作，受聘為華中科技大學88858cc永利官网生理學系教授。

研究方向:

以神經肌肉接頭為模型研究神經突觸形成發育的分子機制

神經肌肉接頭相關的神經疾病的發病機理

聯系方式：

華中科技大學同濟醫學院

88858cc永利官网2号樓1621室

Email： zhangbin@mails.tjmu.edu.cn

主要學術論文：

1.Lei Li*, Yu Cao*, Haitao Wu, Xinchun Ye, Zhihui Zhu, Guanglin Xing, Chengyong Shen, Arnab Barik, Bin Zhang, Xiaoling Xie, Wenbo Zhi, Lin Gan, Huabo Su, Wen-Cheng Xiong, Lin Mei. Enzymatic Activity of the Scaffold Protein Rapsyn for Synapse Formation. Neuron. 92(5):1007-1019, 2016. *, equal contributing authors.

2.Chao Shi, Xuan Huang, Bin Zhang, Dan Zhu, Huqiao Luo, Quqin Lu, Wen-Cheng Xiong, Lin Mei, Shiwen Luo. The Inhibition of Heat Shock Protein 90 Facilitates the Degradation of Poly-Alanine Expanded Poly (A) Binding Protein Nuclear 1 via the Carboxyl Terminus of Heat Shock Protein 70-Interacting Protein. PLoS One. 10(9):e0138936, 2015.

3.Robert P. Lisak, Bin Zhang, Chengyong Shen, Lin Mei. Neuromuscular junction as Achilles' heel: yet another autoantibody? Neurology. 84(2):214-5, 2015.

4.Arnab Barik, Bin Zhang, Gurkirpal S. Sohal, Wen-Cheng Xiong, Lin Mei. Crosstalk between Agrin and Wnt signaling pathways in development of vertebrate neuromuscular junction. Dev Neurobiol. 74(8):828-38, 2014

5.Bin Zhang*, Chengyong Shen*, Beverly Bealmear, Samia Ragheb, Wen-Cheng Xiong, Richard A. Lewis, Robert P. Lisak, Lin Mei. Autoantibodies to agrin in myasthenia gravis patients. PLoS One. 9(3):e91816, 2014. *, equal contributing authors.

6.Chengyong Shen^※, Yisheng Lu^※,Bin Zhang^※, Dwight Figueiredo, Jonathan Bean, Jiung Jung, Haitao Wu, Arnab Barik, Dong-Min Yin, Wen-Cheng Xiong and Lin Mei. Immunization with LRP4 induces myasthenia gravis in mice. J Clin Invest. 123(12):5190-202, 2013. ^※,equal contributing authors.

7.Bin Zhang, Chuan Liang, Ryan Bates, Yiming Yin, Wen-Cheng Xiong, Lin Mei. Wnt proteins regulate acetylcholine receptor clustering in muscle cells. Mol Brain. 5:7, 2012.

8.Yinong Zong, Bin Zhang, Shenyan Gu, Kwangkook Lee, Jie Zhou, Guorui Yao, Dwight Figueiredo, Kay Perry, Lin Mei, Rongsheng Jin. Structural basis of agrin-LRP4-MuSK signaling. Genes Dev. 26(3): 247-58, 2012

9.Bin Zhang, John S. Tzartos, Maria Belimezi, Samia Ragheb, Beverly Bealmear, Richard A. Lewis, Wen-Cheng Xiong, Robert P. Lisak, Socrates J. Tzartos, Lin Mei. Autoantibodies to Lipoprotein-Related Protein 4 in patients with double-seronegative myasthenia gravis. Arch Neurol. 69(4):445-51, 2012. Epub 2011 Dec

 10.Fei Xiong, Sergey Leonov, Amber Cyan Howard, Shan Xiong, Bin Zhang, Lin Mei, Paul McNeil, Sylvia Simon, Wen-Cheng Xiong. Receptor for Advanced Glycation End Products (RAGE) prevents endothelial cell membrane resealing and regulates  F-actin remodeling in a β-Catenin-dependent Manner. J. Biol. Chem. 286: 35061-70, 2011.

11.Shi-wen Luo, Chun Zhang, Bin Zhang, C-H. Kim, Y-Z. Qiu, Lin Mei, and Wen-Cheng Xiong. Regulation of heterochromatin remodeling and myogenin expression by FAK interaction with MBD2. EMBO J, 28(17): 2568-82, 2009.

12.Bin Zhang, Shi-wen Luo, Qiang Wang, Tatsuo Suzuki, Wen-Cheng Xiong, Lin Mei. LRP4 serves as a coreceptor of agrin. Neuron. 60(2):285-97, 2008 .

13.Shi-wen Luo, Bin Zhang, Xian-ping Dong, Yanmei Tao, Annie Ting ,Zheng Zhou, James Meixiong, Junjie Luo, F.C. Alex Chiu, Wen C. Xiong, Lin Mei. HSP90 beta regulates rapsyn turnover and subsequent AChR cluster formation and maintenance. Neuron. 60(1):97-110, 2008

14.Xiao-Ming Li*, Xian-Ping Dong*, Shi-Wen Luo, Bin Zhang, Dae-Hoon Lee, Annie K L Ting, Hannah Neiswender, Chang-Hoon Kim, Ezekiel Carpenter-Hyland, Tian-MingGao, Wen-Cheng Xiong, Lin Mei. Retrograde regulation of motoneuron differentiation by muscle β-catenin. Nat Neurosci. 11(3):262-8, 2008. *, equal contributing authors.

15.Qiang Wang*, Bin Zhang*, Ye Elaine Wang, Wen-Cheng Xiong, Lin Mei. The Ig1/2 domain of MuSK binds to muscle surface and is involved in acetylcholine receptor clustering. Neurosignals. 16(2-3):246-53, 2008. *, equal contributing authors

16. Bin Zhang*, Shi-wen Luo*, Xian-Ping Dong*, Xian Zhang, Chunming Liu, Zhenge Luo, Wen-Cheng Xiong, Lin Mei. β-Catenin regulates AChR clustering in muscle cells through interaction with rapsyn. J. Neurosci. 27:3968-73, 2007. *, equal contributing authors

文獻綜述:

1. Bin Zhang, Wen-Cheng Xiong, Lin Mei. Get ready to Wnt: prepatterning in neuromuscular junction formation. Dev Cell. 16(3):325-7, 2009.

2. G. C. Dobbins, Bin Zhang, Wen C. Xiong, and Lin Mei. The role of the cytoskeleton in neuromuscular junction formation. J. Mol. Neurosci. 30:115-118, 2006.

3. Qiang Wang, Bin Zhang, Wen-Cheng Xiong, and Lin Mei. MuSK signalings at the neuromuscular junction. J. Mol. Neurosci. 30:223-226, 2006.