趙俊

工作單位： 華中科技大學同濟醫學院88858cc永利官网解剖系職位： 教授

電子郵箱: junzhao1981@hust.edu.cn

教育背景

1999-2004 中國科學技術大學化學系學士學位

2005-2006 美國印第安納大學-普渡大學印第安納波利斯分校 (Indiana University Purdue University Indianapolis) 生物醫學工程系碩士學位

2006-2009 美國普渡大學（Purdue University）生物醫學工程系哲學博士學位（導師：Professor Dong Xie）

工作經曆

2009-2015 博士後，美國得克薩斯大學安德森癌症中心（導師：李春教授）

2015-2019 講師， 美國得克薩斯大學安德森癌症中心癌症系統影像系

2019-至今 教授，華中科技大學同濟醫學院88858cc永利官网解剖系

研究領域

納米醫學、介入治療、免疫治療、核醫學影像。主要研究方向：新型納米藥劑的開發與臨床轉化、腫瘤靶向藥物遞送、腫瘤微環境調節與療效增敏。

主要學術成果

本人的研究對象，是以胰腺癌為代表的具有高度耐藥性的實體腫瘤。針對胰腺癌纖 維化程度高、藥物遞送困難的特點，開發了一種新型高分子納米載體，在多個動物模型中 成功調節了腫瘤微環境，提高了藥物遞送效率，并顯著增強了放、化療與免疫治療的療效。成果已發表于 Journal of Controlled Release、Biomaterials 及 ACS Nano 等。該納米制劑已在中美兩國申請專利。此外，本人在國際上首先闡明，不可逆電穿孔介入療法（IRE）可 降低胰腺腫瘤微環境的免疫抑制性。利用 IRE 顯著提高了免疫檢查點抑制劑對胰腺癌的療效。成果将于近期發表于 Nature Communications。本人對腫瘤光熱治療及核醫學影像方向也有涉及， 成果發表于 Biomaterials，Applied Materials Today 、Nanoscale 等 。近五年内以第一作者或共同第一作者身份發表學術論文 14 篇，涵蓋藥學、材料學和影像學等領域， 共計影響因子 98.3。已主持或參與學術基金 4 項。長期擔任 Advanced Functional Materials,

Acta Biomaterialia 等國際期刊審稿人。科研基金

1. 納米藥物緩釋調控腫瘤相關中性粒細胞以增強胰腺癌對不可逆電穿孔聯合 PD1 單抗治療響應的研究，國家自然科學基金面上項目 82073400，2021.01-2024.12，55 萬元，主持

2. Improve Radiation Efficacy in Pancreatic Tumor using Nanoparticle-bound Radiosensitizer，安德森癌症中心，4/1/2016-3/31/2017, $30,000，項目負責人

3. Determination of the efficacy of TIG1-targeted therapy using nanoparticle-delivered siRNA in inflammatory breast cancer, Morgan Welch 炎性乳腺癌研究計劃, 4/1/2016- 3/31/2017, $40,000，項目共同負責人

4. Targeted Delivery of Cyclopamine by Biodegradable Cross-Linked Polymeric Micelles for Radio-Chemotherapy of Pancreatic Cancer ， Skip Viragh 基金會， 2012-2018 ，

$1,400,000，合作研究人

5. Simultaneous Ablation of Tumor Cells and Tumor Stromal Cells to Enhance Antitumor against Pancreatic Ductal Adenocarcinoma，Gillson Longenbaugh 基金會，2016-2018，

$80,000，合作研究人

專利

Chun Li, Jun Zhao, Jason Fleming. Polymeric Drug Delivery Systems for Treatment of Disease, United States, 62/265,167, Pending

代表性 SCI 論文

1. Lincha, V. R. †; Zhao, J. †; Wen, X.; Xiong, C.; D, S. L. Chow; and Li, C., A polymeric micellar drug delivery system developed through a Design of Experiment approach improves pancreatic tumor accumulation of calcipotriol and paclitaxel. International

Journal Pharmaceutics, 2021: p. 120523（影響因子 4.845）

2. Bao, G.; Tang, M.; Zhao, J.*; and Zhu, X.*, Nanobody: a promising toolkit for molecular imaging and disease therapy. EJNMMI Res, 2021. 11(1): p. 6. DOI: 10.1186/s13550-021-

00750-5（影響因子 2.640）

3. Wu, Z. L. †; Zhao, J. †; and Xu, R., Recent advances in oral nano-antibiotics for bacterial infection therapy. Interntional Journal of Nanomedicine, 2020. 15: p. 9587-9610（影響因子 5.115）

4. Xiong, C.; Wen, Y.; Zhao, J.; Yin, D.; Xu, L.; Chelariu-Raicu, A.; Yao, C.; Leng, X.; Liu, J.; Chaudhari, RR.; Zhang, S.; Sood, AK.; Li, C. Targeting Forward and Reverse EphB4/EFNB2 Signaling by a Peptide with Dual Functions. Scientific Reports, 2020. 10(1): p. 520（影響因子 3.998）

5. Lincha, V. R.; Hsiao, C.-H.; Zhao, J.; Li, C.; Chow, D. S.-L. Sensitive and rapid UHPLC– MS/MS assay for simultaneousquantifications of calcipotriol and paclitaxel in rat whole blood andplasma samples. Journal of Pharmaceutical and Biomedical Analysis, 2021, 192: 113685（影響因子 3.209） 

6. Cao, Q. †; Wang, W. †; Zhou, M. †; Huang, Q.; Wen, X.; Zhao, J.; Shi, S.; Geng, K.; Li, F.; Hatakeyama, H.; Xu, C.; Piwnica-Worms, D.; Peng, W.; Zhou, D.; Sood, A. K.; and Li, C., Induction of antitumor immunity in mice by the combination of nanoparticle-based photothermolysis and anti-PD-1 checkpoint inhibition. Nanomedicine: Nanotechnology, Biology and Medicine, 2020. 25: p. 102169（影響因子 5.182）

7. Zhao, J.†; Wen, X.†; Li, T.; Shi, S.; Xiong, C.; Wang, Y. A.; and Li, C., Concurrent Injection of Unlabeled Antibodies Allows Positron Emission Tomography Imaging of Programmed Cell Death Ligand 1 Expression in an Orthotopic Pancreatic Tumor Model. ACS Omega, 2020, 5(15): p. 8474-8482（共同一作，影響因子 2.87）

8. He, J. †; Qiao, Y. †; Zhang H. †; Zhao, J. †; Li, W.; Xie, T.; Zhong, D.; Wei, Q.; Hua, S.; Yu, Y.; Yao, K.; Santos, H.; Zhou M. Gold–silver nanoshells promote wound healing from drug-resistant bacteria infection and enable monitoring via surface-enhanced Raman scattering imaging. Biomaterials 2020, 234, 119763（共同一作，影響因子 10.274）

9. Zhong, D. †; Zhao, J. †; Li, Y; Qiao, Y.; Wei, Q.; He, J.; Xie, T.; Li, W., Zhou, M. Laser- triggered aggregated cubic α-Fe2O3@Au nanocomposites for magnetic resonance imaging and photothermal/enhanced radiation synergistic therapy. Biomaterials 2019, 210, 119369

（共同一作，影響因子 10.274）

10. Zhao, J.†; Wen, X. F.†; Tian, L.; Li, T.; Xu, C.; Wen, X. X.; Melancon, M. P., Gupta, S.; Shen, B.; Peng, W.; Li, C. Irreversible electroporation reverses resistance to immune checkpoint blockade in pancreatic cancer. Nature Communications 2019, 10:899（影響因子 11.880）

11. Zhao, J.; Xiao, Z.; Li, T.; Chen, H.; Yuan, Y.; Wang, A. Y.; Hsiao, C. -H.; Chow, D. S.- L.; Overwijk, W.; Li, C. Stromal modulation reverses primary resistance to immune checkpoint blockade in pancreatic cancer. ACS Nano 2018, 12, 9881-9893.（影響因子13.709）

12. Zhou, B.†; Zhao, J.†; Qiao, Y.; Wei, Q.; He, J.; Li, W.; Zhong, D.; Ma, F.; Li, Y.; Zhou,

M. Simultaneous multimodal imaging and photothermal therapy via renal-clearable manganese-doped copper sulfide nanodots. Applied Materials Today 2018, 13, 285-297.

（共同一作，影響因子 8.013）

13. Zhao, J.; Wang, H.; Hsiao, C.-H.; Chow, D. S.-L.; Koay, E. J.; Kang, Y.; Wen, X.; Huang, Q.; Ma, Y.; Bankson, J. A.; et al. Simultaneous inhibition of hedgehog signaling and tumor proliferation remodels stroma and enhances pancreatic cancer therapy. Biomaterials 2018, 159, 215-228. （影響因子 10.273）

14. Zhao, J.; Koay, E. J.; Li, T.; Wen, X.; Li, C., A hindsight reflection on the clinical studies of poly (l‐glutamic acid)‐paclitaxel. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 2018, 10 (3), e1497.（影響因子 6.35）

15. Wang, W.†; Zhao, J.†; Wen, X.; Lin, C. C.-J.; Li, J.; Huang, Q.; Yu, Y.; Lin, S.-Y.; Li, C., MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer. Contrast Media & Molecular Imaging 2017, 2017. （共同一作，影響因子 2.934） 

16. Zhao, J.; Zhou, M.; Li, C., Synthetic nanoparticles for delivery of radioisotopes and radiosensitizers in cancer therapy. Cancer Nanotechnology 2016, 7 (9). (影響因子 4.22）

17. Zhou, M.; Zhao, J.; Tian, M.; Song, S.; Zhang, R.; Gupta, S.; Tan, D.; Shen, H.; Ferrari, M.; Li, C., Radio-photothermal therapy mediated by a single compartment nanoplatform depletes tumor initiating cells and reduces lung metastasis in the orthotopic 4T1 breast tumor model. Nanoscale 2015, 7 (46), 19438-19447.（影響因子 7.233）

18. Zhou, M.; Song, S.; Zhao, J.; Tian, M.; Li, C., Theranostic CuS nanoparticles targeting folate receptors for PET image-guided photothermal therapy. Journal of Materials Chemistry B 2015, 3 (46), 8939-8948.（影響因子 4.543）

19. Zhao, J.; Wu, C.; Abbruzzese, J.; Hwang, R. F.; Li, C., Cyclopamine-loaded core-cross- linked polymeric micelles enhance radiation response in pancreatic cancer and pancreatic stellate cells. Molecular Pharmaceutics 2015, 12 (6), 2093-2100. （影響因子 4.556）

20. Zhao, J.; Qiao, Y.; Zhou, M.; Wallace, M.; Gupta, S.; Li, C.; Melancon, M. P., Antitumor Efficacy of Irreversible Electroporation and Doxorubicin-Loaded Polymeric Micelles. ACS Macro Letters 2015, 4 (10), 1081-1084.（影響因子 6.131）

21. Zhao, J.; Lee, P.; J Wallace, M.; P Melancon, M., Gold nanoparticles in cancer therapy: efficacy, Biodistribution, and Toxicity. Current Pharmaceutical Design 2015, 21 (29), 4240-4251.（影響因子 2.757）

22. You, J.†; Zhao, J.†; Wen, X.; Wu, C.; Huang, Q.; Guan, F.; Wu, R.; Liang, D.; Li, C., Chemoradiation therapy using cyclopamine-loaded liquid–lipid nanoparticles and lutetium-177-labeled core-crosslinked polymeric micelles. Journal of Controlled Release 2015, 202, 40-48. （共同一作，影響因子 7.877）

23. Zhao, J.; Wallace, M.; Melancon, M. P., Cancer theranostics with gold nanoshells.

Nanomedicine 2014, 9 (13), 2041-2057.（影響因子 5.005）

24. Zhao, J.; Vykoukal, J.; Abdelsalam, M.; Recio-Boiles, A.; Huang, Q.; Qiao, Y.; Singhana, B.; Wallace, M.; Avritscher, R.; Melancon, M. P., Stem cell-mediated delivery of SPIO- loaded gold nanoparticles for the theranosis of liver injury and hepatocellular carcinoma. Nanotechnology 2014, 25 (40), 405101.（影響因子 3.404）

25. Zhao, J.†; Song, S.†; Zhong, M.; Li, C., Dual-Modal Tumor Imaging via Long-Circulating

Biodegradable Core-Cross-Linked Polymeric Micelles. ACS Macro Letters 2011, 1 (1), 150-153. （影響因子 6.131)

國際會議報告邀請報告

1. Zhao J., Wu C., Li J., Hwang R.,Li C. “Cyclopamine-loaded Core-crosslinked Polymeric Micelles Enhanced Radiation Response in Pancreatic Cancer”. 10th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Valencia, Spain, 5/2014