王維民

教授，博士生導師

海外高層次人才（青年千人）

湖北省百人計劃

湖北省傑出青年項目

華中科技大學88858cc永利官网免疫系

研究方向：細胞代謝和腫瘤免疫治療

個人簡介：2006年畢業于蘭州大學并取得生物學學士學位，2011年畢業于北京協和醫學院基礎學院生物化學與分子生物學專業并取得博士學位，2011年至2019年期間先後在美國密歇根大學醫學院婦産科和外科進行博士後研究。2019年入職華中科技大學88858cc永利官网免疫學系任教授、博士生導師，現擔任88858cc永利官网副院長、免疫學系主任。入選國家“海外高層次人才（青年項目）”、湖北省“百人計劃”，兼任湖北省醫學生物免疫學基礎免疫專委會主委、中國免疫學會細胞治療專委會委員、中國細胞生物學會細胞死亡專委會委員。承擔科技部國家重點研發計劃、國家自然科學基金和湖北省傑出青年基金等項目6項。在探索效應性T細胞對腫瘤細胞代謝和死亡調控領域取得了一系列創新性研究成果，近年來主要代表性成果發表在Nature、Cell、Cancer Cell、Cell Metabolism和Nature Communications等國際主流學術期刊。目前主要從事細胞死亡、脂質代謝及腫瘤免疫調控相關研究。

聯系方式：

武漢市航空路13号88858cc永利官网2号樓1022

email:  weiminw@hust.edu.cn

代表性學術論文：

1. Lai Y, Gao Y, Lin J, Liu F, Yang L, Zhou J, Xue Y, Li Y, Chang Z, Li J, Chao T, Chen J, Cheng X, Gao X, Li X, Lu F, Chu Q, Wang W. Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5. Cell Metabolism. 2024 Feb 8:S1550-4131(24)00012-3.

2. Xue Y, Lu F, Chang Z, Li J, Gao Y, Zhou J, Luo Y, Lai Y, Cao S, Li X, Zhou Y, Li Y, Tan Z, Cheng X, Li X, Chen J, Wang W. Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade. Nature Communications. 2023 Aug 8;14(1): 4758.

3. Liao P*, Wang W*, Wang W, Kryczek I, Li X, Bian Y, Sell A, Wei S, Grove S, Johnson JK, Kennedy PD, Gijón M, Shah YM, Zou W. CD8⁺ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4. Cancer Cell. 2022 Feb; S1535-6108(22)00036-8 (co-first)

4. Wang W*, Zou W*. Amino acid and their transporters in T cell immunity and cancer therapy. Molecular Cell. 2020 Nov; 80(3):384-395 (co-corresponding).

5. Wang W, Green M, Choi JE, Gijón M, Kennedy PD, Johnson JK, Liao P, Lang X, Kryczek I, Sell A, Xia H, Zhou J, Li G, Li J, Li W, Wei S, Vatan L, Zhang H, Szeliga W, Gu W, Liu R, Lawrence TS, Lamb C, Tanno Y, Cieslik M, Stone E, Georgiou G, Chan TA, Chinnaiyan A, Zou W. CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy. Nature. 2019 May;569(7755):270-274.

6. Wang W, Kryczek I, Dostál L, Lin H, Tan L, Zhao L, Lu F, Wei S, Maj T, Peng D, He G, Vatan L, Szeliga W, Kuick R, Kotarski J, Tarkowski R, Dou Y, Rattan R, Munkarah A, Liu JR, Zou W. Effector T cells abrogate stroma-mediated chemoresistance in ovarian cancer. Cell. 2016 May 19; 165(5): 1092-105.

7. Wang W, Zou W, Liu R. Tumor-infiltrating T cells in epithelial ovarian cancer: predictors of prognosis and biological basis of immunotherapy. Gynecol Oncol. 2018 Oct;151(1):1-3.

8. Wang W, Liu JR, Zou W. Immunotherapy in Ovarian Cancer. Surg Oncol Clin N Am. 2019 Jul; 28(3):447-464.

9. Wang W, Green M, Liu R, Lawrence T, Zou W. CD8+ T cells in Immunotherapy, Radiotherapy and Chemotherapy. Oncoimmunology, 2018. doi.org/10.1007/978-3-319-62431-0_3.

10. Wang W, Zhou J, Zhang Y, Liu S, Liu Y, Zheng D. HTLV-1 Tax-deregulated both autophagy pathway and c-FLIP expression contribute to the resistance against death receptor-mediated apoptosis. J Virol. 2014 Mar; 88(5):2786-98.

11. Lang X, Green MD, Wang W, Yu J, Choi JE, Jiang L, Liao P, Zhou J, Zhang Q, Dow A, Saripalli AL, Kryczek I, Wei S, Szeliga W, Vatan L, Stone EM, Georgiou G, Cieslik M, Wahl DR, Morgan MA, Chinnaiyan AM, Lawrence TS, Zou W. Radiotherapy and Immunotherapy Promote Tumoral Lipid Oxidation and Ferroptosis via Synergistic Repression of SLC7A11. Cancer Discov. 2019 Dec; 9(12):1673-1685.

12. Maj T, Wang W, Wang W, Wei S, Zhao L, Linda Vatan L, Szeliga W, Liu R, Kryczek I, Zou W. Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1 blockade in the tumor microenvironment. Nat Immunol, 2017 Dec;18(12):1332-1341.

13. Tan L, Wang W, He G, Kuick RD, Gossner G, Kueck AS, Wahl H, Opipari AW, Liu JR. Resveratrol inhibits ovarian tumor growth in an in vivo mouse model. Cancer. 2016 Mar 1; 122(5): 722-9.

14. Peng D, Kryczek I, Nagarsheth N, Zhao L, Wei S, Wang W, Sun Y, Zhao E, Vatan L, Szeliga W, Kotarski J, Tarkowski R, Dou Y, Cho K, Hensley-Alford S, Munkarah A, Liu R, Zou W. Epigenetic silencing of TH1-type chemokines shapes tumour immunity and immunotherapy. Nature. 2015 Nov 12; 527(7577): 249-53