唐科 教授 國家優青

ketang@hust.edu.cn

華中科技大學，同濟88858cc永利官网

專業方向 腫瘤免疫、腫瘤生物治療、細胞代謝調控

課題組長期從事腫瘤免疫中關鍵細胞群體（T細胞和腫瘤幹細胞）等方面的研究工作，重點研究腫瘤免疫T細胞長期的存活和腫瘤幹細胞自我更新的代謝調控機制，并緻力于新型腫瘤免疫生物治療技術的開發與臨床轉化。

近五年來在細胞代謝和腫瘤免疫治療領域以第一/通訊作者（含共同)在 Nature Immunology、Nature Cell Biology、Cellular & Molecular Immunology、Cancer Research和 Cancer immunology research等雜志發表多篇論文；作為主要發明人申報國内和國際PCT專利10項，授權5項。

學習經曆

科研與學術工作經曆

主要社會兼職

1．中國免疫學會腫瘤免疫與生物治療分會委

2．Bioengineering客座主編

3．中國免疫學會會員；中國免疫學會腫瘤免疫與生物治療分會委

主持科研項目

1. 國家自然科學基金委員會，優秀青年科學基金項目，8232204，代謝調控與腫瘤免疫治療新策略，2024-01 至 2026-12，200萬元，在研，主持。

2. 科學技術部高技術研究發展中心，國家重點研發計劃（子課題），2022YFA1206000，工程化細胞微顆粒納米藥物可控制備及其腫瘤治療新技術，2023-05 至 2028-04，225萬元，在研，主持。

3. 國家自然科學基金委員會, 專項項目, 82150103, 腫瘤代謝微環境對中性粒細胞趨化、功能和代謝表型的影響以及相關機制探究, 2022-01-01 至 2024-12-31, 250萬元, 在研, 主持。

4. 國家自然科學基金委員會, 面上項目, 82071864, 細胞來源的載藥囊泡激發中性粒細胞抑制惡性胸腔積液相關機制研究, 2021-01-01 至 2024-12-31, 55萬元, 在研, 主持。

5. 湖北省科技廳, 湖北省重點研發計劃, 2020BCA068, 肺癌個體化生物免疫化療與放療聯合創新技術與臨床應用研究（子課題）, 2020-01 至 2022-12, 50萬元, 結題, 主持。

6. 國家自然科學基金委員會, 重大研究計劃, 91742112, 負載化療藥物的腫瘤微顆粒：重塑肺癌癌性胸水免疫微環境的機理探究, 2018-01-01 至 2020-12-31, 57萬元, 結題, 參與。

7. 中國科學技術協會, 青年人才托舉工程, YESS20160166, 探尋細胞來源囊泡在腫瘤生物治療和腫瘤免疫治療中的作用, 2017-01 至 2019-12, 45萬元, 結題, 主持。

特邀會議報告

所獲獎勵

1. 2015年在第五屆中國免疫學會獲得青年免疫學者獎；

2. 2016年入選中國科學技術協會“青年人才托舉工程”；

3. 2018年入選華中科技大學青年學術前沿團隊（骨幹成員）；

4. 2021年入選首批湖北省“青年拔尖人才”培養計劃；

5. 2021年入選湖北省人才工作小組“科技副總”。

已發表論文（#并列第一作者，*通訊作者）

(1) Tang K, Zhang H, Deng J, Wang D, Liu S, Lu S, Cui Q, Chen C, Liu J, Yang Z, Li Y, Chen J, Lv J, Ma J, Huang B. Ammonia detoxification promotes CD8+ T cell memory development by urea and citrulline cycles. Nat Immunol. 2023 Jan;24(1):162-173.

(2) Tang K, Ma J, Huang B. Macrophages' M1 or M2 by tumor microparticles: lysosome makes decision. Cell Mol Immunol. 2022 Oct;19(10):1196-1197.

(3) Wang D, Wu X, Jiang G, Yang J, Yu Z, Yang Y, Yang W, Niu X, Tang K^*, Gong J. Systematic analysis of the effects of genetic variants on chromatin accessibility to decipher functional variants in non-coding regions. Front Oncol. 2022 Oct 18;12:1035855.

(4) Tang K, Zhu L, Chen J, Wang D, Zeng L, Chen C, Zhou Y, Lv J, Liu Y, Zhang H, Ma J, Huang B. Hypoxia Promotes Breast Cancer Cell Growth by Activating a Glycogen Metabolic Program. Cancer Res. 2021 ;81(19):4949-63.

(5) Ma J^#, Tang K^#, Zhang H^#, Wei K, Huang B. Characterization and Functional Analysis of Tumor-Derived Microparticles. Curr Protoc. 2021;1(6):e144.

(6) Zhang H^#, Tang K^#, Ma J^#, Zhou L, Liu J, Zeng L, Zhu L, Xu P, Chen J, Wei K, Liang X, Lv J, Xie J, Liu Y, Wan Y, Huang B. Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T cell memory development. Nat Cell Biol. 2020 Jan;22(1):18-25.

(7) Chen J, Sun W, Zhang H, Ma J, Xu P, Yu Y, Fang H, Zhou L, Lv J, Xie J, Liu Y, Tang K*, Huang B*. Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β. Cell Mol Immunol. 2020;17:1233-1244.

(8) Zhang H^#, Ma J^#, Tang K^#, Huang B. Beyond energy storage: roles of glycogen metabolism in health and disease. FEBS J. 2020 Nov 29.

(9) Ma J^#, Zhang H^#, Tang K^#, Huang B. Tumor-derived microparticles in tumor immunology and immunotherapy. Eur J Immunol. 2020 Nov;50(11):1653-1662.

(10) Xu P^#, Tang K^#, Ma J^#, Zhang H, Wang D, Zhu L, Chen J, Wei K, Liu J, Fang H, Tang L, Zhang Y, Xie J, Liu Y, Meng R, Liu L, Dong X, Yang K, Wu G, Ma F, Huang B. Chemotherapeutic tumor microparticles elicit a neutrophil response targeting malignant pleural effusions. Cancer Immunol Res. 2020 Sep;8(9):1193-1205.

(11) Tang K^#, Yu Y^#, Zhu L^#, Xu P, Chen J, Ma J, Zhang H, Fang H, Sun W, Zhou L, Wei K, Li F, Lv J, Xie J, Liu Y, Huang B. Hypoxia-reprogrammed tricarboxylic acid cycle promotes the growth of human breast tumorigenic cells. Oncogene. 2019 Oct;38(44):6970-6984.

(12) Liu J^#, Ma J^#, Tang K^#, Huang B. Therapeutic Use of Tumor Cell-Derived Extracellular Vesicles. Methods Mol Biol. 2017;1660:433-440.

(13) Tang K, Hu L, Ma J, Zhang H, Zhang Y, Li Y, Ma R, Luo S, Liu D, Long G, Han M, Liu S, Song A, Shen M, Hu G, Huang B. Brief Report: Human mesenchymal stem-like cells facilitate floating tumorigenic cell growth via glutamine-ammonium cycle. Stem Cells. 2015 Sep;33(9):2877-84.

(14) Zhang H^#, Tang K^#, Zhang Y^#, Ma R, Ma J, Li Y, Luo S, Liang X, Ji T, Gu Z, Lu J, He W, Cao X, Wan Y, Huang B. Cell-free tumor microparticle vaccines stimulate dendritic cells via cGAS/STING signaling. Cancer Immunol Res. 2015 Feb;3(2):196-205.

(15) Ma R^#, Zhang W^#, Tang K^#, Zhang H, Zhang Y, Li D, Li Y, Xu P, Luo S, Cai W, Ji T, Katirai F, Ye D, Huang B. Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma. Nat Commun. 2013;4:2508.

(16) Tang K, Zhang Y, Zhang H, Xu P, Liu J, Ma J, Lv M, Li D, Katirai F, Shen GX, Zhang G, Feng ZH, Ye D, Huang B. Delivery of chemotherapeutic drugs in tumour cell-derived microparticles. Nat Commun. 2012;3:1282.

(17) Tang K, Liu J, Yang Z, Zhang B, Zhang H, Huang C, Ma J, Shen GX, Ye D, Huang B. Microparticles mediate enzyme transfer from platelets to mast cells: A new pathway for lipoxin A4 biosynthesis. Biochem Bioph Res Co. 2010;400:432-436.

參與發表的論著

(1) Chen J, Zhou Y, Liu Z, Lu Y, Jiang Y, Cao K, Zhou N, Wang D, Zhang C, Zhou N, Shi K, Zhang L, Zhou L, Wang Z, Zhang H, Tang K, Ma J, Lv J, Huang B*. Hepatic glycogenesis antagonizes lipogenesis by blocking S1P via UDPG. Science. 2024 Feb 16;383(6684):eadi3332.

(2) Ma J, Tang L, Tan Y, Xiao J, Wei K, Zhang X, Ma Y, Tong S, Chen J, Zhou N, Yang L, Lei Z, Li Y, Lv J, Liu J, Zhang H, Tang K,  Zhang Y, Huang B*. Lithium carbonate revitalizes tumor-reactive CD8+ T cells by shunting lactic acid into mitochondria. Nat Immunol. 2024 Jan 23.

(3) Zhou Y, Wang D, Zhou L, Zhou N, Wang Z, Chen J, Pang R, Fu H, Huang Q, Dong F, Cheng H, Zhang H, Tang K, Ma J, Lv J, Cheng T, Fiskesund R, Zhang X*, Huang B*. Cell softness renders cytotoxic T lymphocytes and T leukemic cells resistant to perforin-mediated killing. Nat Commun. 2024 Feb 15;15(1):1405.

(4) Zhang H, Yang Z, Yuan W, Liu J, Luo X, Zhang Q, Li Y, Chen J, Zhou Y, Lv J, Zhou N, Ma J, Tang K, Huang B*. Sustained AhR activity programs memory fate of  effector CD8⁺ T cells. Proc Natl Acad Sci USA. 2024 Mar 12;121(11):e2317658121.

(5) Zhou L, Wu D, Zhou Y, Wang D, Fu H, Huang Q, Qin G, Chen J, Lv J, Lai S, Zhang H, Tang K, Ma J, Fiskesund R, Zhang Y, Zhang X*, Huang B*. Tumor cell-released kynurenine biases MEP differentiation into megakaryocytes in individuals with cancer by activating AhR-RUNX1. Nat Immunol. 2023 Dec;24(12):2042-2052.

(6) Wei K, Zhang H, Yang S, Cui Y, Zhang B, Liu J, Tang L, Tan Y, Liu S, Chen S, Yuan W, Luo X, Chen C, Li F, Liu J, Chen J, Xu P, Lv J, Tang K, Zhang Y, Ma J, Huang B*. Chemo-drugs in cell microparticles reset antitumor activity of macrophages by activating lysosomal P450 and nuclear hnRNPA2B1. Signal Transduct Target Ther.  2023 Jan 20;8(1):22.

(7)  Zhou N, Chen J, Ling Z, Zhang C, Zhou Y, Wang D, Zhou L, Wang Z, Sun N, Wang X, Zhang H, Tang K, Ma J, Lv J, Huang B*.AHR sulfenylation promotes glycogenolysis and rescues cancer chemoresistance.J Clin Invest. 2023 Dec 15;133(24):e170753.

(8)  Lv J, Zhou Y, Zhou N, Wang Z, Chen J, Chen H, Wang D, Zhou L, Wei K, Zhang H, Tang K, Ma J, Liu Y, Wan Y, Zhang Y, Zhang H, Huang B*. Epigenetic modification of CSDE1 locus dictates immune recognition of nascent tumorigenic cells. Sci Transl Med. 2023 Feb;15(681):eabq6024.

(9) Zhang H, Liu J, Yang Z, Zeng L, Wei K, Zhu L, Tang L, Wang D, Zhou Y, Lv J, Zhou N, Tang K, Ma J, Huang B. TCR activation directly stimulates PYGB-dependent glycogenolysis to fuel the early recall response in CD8+ memory T cells. Mol Cell. 2022 Jun 17:S1097-2765(22)00538-X.

(10) Lv J, Liu Y, Mo S, Zhou Y, Chen F, Cheng F, Li C, Saimi D, Liu M, Zhang H, Tang K, Ma J, Wang Z, Zhu Q, Tong WM, Huang B. Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway. Nat Cell Biol.2022 Mar;24:364-72.

(11) Liu Y*, Zhang T, Zhang H, Li J, Zhou N, Fiskesund R, Chen J, Lv J, Ma J, Zhang H, Tang K, Zhang X, Wang N, Huang B*. Cell softness prevents cytolytic T cell killing of tumor-repopulating cells. Cancer Res. 2021;81(2):476-88.

(12) Gao Y, Zhang H, Zhou N, Xu P, Wang J, Gao Y, Jin X, Liang X, Lv J, Zhang Y, Tang K, Ma J, Zhang H, Xie J, Yao F, Tong W, Liu Y*, Wang X*, Huang B*. Methotrexate-loaded tumour-cell-derived microvesicles can relieve biliary obstruction in patients with extrahepatic cholangiocarcinoma. Nat Biomed Eng. 2020 Jul;4(7):743-53.

(13) Ma J, Wei K, Liu J, Tang K, Zhang H, Zhu L, Chen J, Li F, Xu P, Chen J, Liu J, Fang H, Tang L, Wang D, Zeng L, Sun W, Xie J, Liu Y, Huang B. Glycogen metabolism regulates macrophage-mediated acute inflammatory responses. Nat Commun. 2020 Apr 14;11(1):1769.

(14)  Liang Q, Bie N, Yong T, Tang K, Shi X, Wei Z, Jia H, Zhang X, Zhao H, Huang W, Gan L*, Huang B*, Yang X*. The softness of tumour-cell-derived microparticles regulates their drug-delivery efficiency. Nat Biomed Eng. 2019 Sep;3(9):729-740.

(15) Zhang H, Yu Y, Zhou L, Ma J, Tang K, Xu P, Ji T, Liang X, Lv J, Dong W, Zhang T, Chen D, Xie Jing, Liu Y, Huang B. Circulating tumor microparticles promote lung metastasis by reprogramming inflammatory and mechanical niches via a macrophage-dependent pathway. Cancer Immunol Res. 2018;6:1046-56.

(16) Ma J, Wei K, Zhang H, Tang K, Li F, Zhang T, Liu J, Xu P, Yu Y, Sun W, Zhu L, Chen J, Zhou L, Liang X, Lv J, Fiskesund R, Liu Y, Huang B. Mechanisms underlying presentation of tumor microparticle antigens to CD8+ T cells by dendritic cells. Cancer Immunol Res. 2018;6:1057-68.

(17) Liu Y, Lv J, Liang X, Yin X, Zhang L, Chen D, Jin X, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Xie J, Wang N, Huang B. 3D Fibrin Stiffness mediates Dormancy of Tumor-repopulating cells via a Cdc42-driven Tet2 Epigenetic Program. Cancer Res. 2018;78:3926-37.

(18) Liu Y, Liang X, Dong W, Fang Y, Lv J, Zhang T, Fiskesund R, Xie J, Liu J, Yin X, Jin X, Chen D, Tang K, Ma J, Zhang H, Yu J, Yan J, Liang H, Mo S, Cheng F, Zhou Y, Zhang H, Wang J, Li J, Chen Y, Cui B, Hu ZW, Cao X, Qin FX, Huang B. Tumor repopulating cells induce PD-1 expression in CD8+ T cells by transferring kynurenine and AhR activation. Cancer Cell. 2018;33:480-494.

(19) Liu Y, Lv J, Liu J, Liang X, Jin X, Xie J, Zhang L, Chen D, Fiskesund R, Tang K, Ma J, Zhang H, Dong W, Mo S, Zhang T, Cheng F, Zhou Y, Jia Q, Zhu B, Kong Y, Guo J, Zhang H, Hu ZW, Cao X, Qin FX, Huang B. STAT3/p53 pathway activation disrupts IFN-β-induced dormancy in tumor-repopulating cells. J Clin Invest. 2018;128:1057-73.

(20) Chen D, Xie J, Fiskesund R, Dong W, Liang X, Lv J, Jin X, Liu J, Mo S, Zhang T, Cheng F, Zhou Y, Zhang H, Tang K, Ma J, Liu Y, Huang B. Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages towards M1 phenotype. Nat Commun. 2018;9:873.

(21)  Ma R, Ji T, Zhang H, Dong W, Chen X, Xu P, Chen D, Liang X, Yin X, Liu Y, Ma J, Tang K, Zhang Y, Peng Y, Lu J, Zhang Y, Qin X, Cao X, Wan Y, Huang B. A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells. Nat Cell Biol. 2018;20:21-27.

(22) Liu Y, Liang X, Yin X, Lv J, Tang K, Ma J, Ji T, Zhang H, Dong W, Jin J, Chen D, Li Y, Zhang S, Xie H, Zhao B, Zhao T, Lu J, Hu Z, Cao X, Qin X, Huang B. Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells. Nat Commun. 2017 May 10;8:15207.

(23) Jin X, Ma J, Liang X, Tang K, Liu Y, Yin X, Zhang Y, Zhang H, Xu P, Chen D, Zhang T, Lu J, Hu Z, Qin X, Zeng X, Li L, Huang B. Pre-instillation of tumor microparticles enhances intravesical chemotherapy of nonmuscle-invasive bladder cancer through a lysosomal pathway. Biomaterials. 2017 Jan;113:93-104.

(24) Ma J, Zhang Y, Tang K, Zhang H, Yin X, Li Y, Xu P, Sun Y, Ma R, Ji T, Chen J, Zhang S, Zhang T, Luo S, Jin Y, Luo X, Li C, Gong H, Long Z, Lu J, Hu Z, Cao X, Wang N, Yang X, Huang B. Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles. Cell Res. 2016 Jun;26(6):713-27.

(25)  Ran L, Tan X, Li Y, Zhang H, Ma R, Ji T, Dong W, Tong T, Liu Y, Chen D, Yin X, Liang X, Tang K, Ma J, Zhang Y, Cao X, Hu Z, Qin X, Huang B. Delivery of oncolytic adenovirus into the nucleus of tumorigenic cells by tumor microparticles for virotherapy. Biomaterials. 2016 May;89:56-66.

(26) Li Y, Luo S, Ma R, Liu J, Xu P, Zhang H, Tang K, Ma J, Zhang Y, Liang X, Sun Y, Ji T, Wang N, Huang B. Upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate tumors. Cancer Res. 2015 Apr 1;75(7):1191-6.

(27) Ma R, Zhang W, Tang K, Zhang H, Zhang Y, Li D, Li Y, Xu P, Luo S, Cai W, Ji T, Katirai F, Ye D, Huang B. Switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma. Nat Commun. 2013;4:2508.

(28)  Li D, Cai W, Gu R, Zhang Y, Zhang H, Tang K, Xu P, Katirai F, Shi W, Wang L, Huang T, Huang B. Th17 cell plays a role in the pathogenesis of Hashimoto's thyroiditis in patients. Clin Immunol. 2013 Dec;149(3):411-20.

(29)  Liu J, Tan Y, Zhang H, Zhang Y, Xu P, Chen J, Poh YC, Tang K, Wang N*, Huang B*. Soft fibrin gels promote selection and growth of tumorigenic cells. Nat Mater. 2012 Jul 1;11(8):734-41.

招生信息

課題組具備雄厚的師資力量，配套有各類國際、國内領先的儀器設備，科研經費充足，科研氛圍濃厚。每年拟招收多名臨床醫學、基礎醫學、藥學、生物學、生物信息學等相關專業的碩士/博士/博士後。歡迎各位熱愛科研的優秀本科生與碩士生申請推薦免試/報考本實驗室！