史岸冰

華中學者領軍崗特聘教授

生物化學和分子生物學系

電話：027-83692608

電子郵箱：ashi@hust.edu.cn

關鍵詞：Endosome cell biology, small GTPase, membrane skeleton, and modeling human diseases in Caenorhabditis elegans 

• 現任華中科技大學同濟88858cc永利官网院長，華中科技大學細胞架構研究中心主任，生物化學和分子生物學系主任。于南開大學獲理學學士學 位，美國羅格斯大學獲碩士和博士學位，美國斯坦福大學進行博士後訓練，2013年回到華中科技大學開展獨立研究工作。

• 主講《醫學細胞及分子生物學》、《生物化學及分子生物學》、《遺傳學》等本科生及研究生課程。擔任《醫學細胞與分子生物學》八年制臨床整合課程負責人、研究生《代謝與疾病基礎研究實驗技術》課程負責人，現任醫學研究生國家級規劃教材《醫學分子生物學》主編，醫學研究生國家級規劃教材《細胞與分子生物學》主編，五年制本科臨床醫學國家級規劃教材《醫學細胞生物學》副主編。

• 主要從事内膜動态及功能相關的基礎研究，運用遺傳操作、超高分辨成像、光遺傳操控、體外重構等多學科方法，探讨内吞體生理病理動态（Ras家族蛋白活性調控；膜骨架動态；膜運輸調控網絡組成及功能模式）、内吞體調控組織衰老、内吞體調控病原微生物-宿主互作等科學問題，相關成果以通訊作者發表在Nature Aging、Journal of Cell Biology、EMBO J、Cell Reports、PLoS Genetics、J Cell Sci、Mol Biol Cell等國際學術刊物。課題組通過建立相應的模式動物在體研究體系，力圖從細胞内膜運輸調控的視角拓展對膜性細胞器在細胞生理病理過程中的重要作用的認識，為發展靶向腸道病原微生物侵染的廣譜策略提供新的見解，為研究衰老相關疾病以及評估抗衰老策略提供理論參考。

Anbing Shi (he/him)

Distinguished Professor, Huazhong University of Science and Technology

Department of Biochemistry and Molecular Biology

Phone: +86-27-83692608

Email: ashi@hust.edu.cn

Keywords: Endosome cell biology, small GTPase, membrane skeleton, and modeling human diseases in Caenorhabditis elegans

Currently serving as the Dean of the School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology; Director of the Cell Architecture Research Center, and Chair of the Department of Biochemistry and Molecular Biology. Dr. Shi obtained his Bachelor's degree from Nankai University and his Master's and Ph.D. degrees from Rutgers University–New Brunswick in the United States. Dr. Shi conducted postdoctoral training at Stanford University and returned to Huazhong University of Science and Technology in 2013 to pursue independent research.

Teaching undergraduate and graduate courses such as "Medical Cell and Molecular Biology," "Biochemistry and Molecular Biology," and "Genetics." He serves as the coordinator of the eight-year integrated course "Medical Cell and Molecular Biology" and is responsible for the graduate course "Basic Research Techniques in Metabolic Disease". He is currently the chief editor of the national planning textbook for medical graduate students, "Medical Molecular Biology," and the chief editor for medical graduate students, "Cell and Molecular Biology". He also serves as the associate editor of the national planning textbook for five-year undergraduate clinical medicine, "Medical Cell Biology".

The laboratory is devoted to investigating the fundamentals of endosome dynamics and its functions. The team employs multidisciplinary approaches, including genetic manipulation, super-resolution imaging, optogenetic control, and in vitro reconstitution to investigate dynamic aspects of endocytic physiology and pathology (regulation of Ras superfamily proteins activity, membrane skeleton dynamics, membrane transport regulatory network composition and functional modes), endosomal regulation of tissue aging, and endosomal regulation of host-pathogen interactions. Relevant findings have been published as corresponding authors in academic journals such as Nature Aging, Journal of Cell Biology, EMBO J, Cell Reports, PLoS Genetics, J Cell Sci, and Mol Biol Cell. The team is attempting to increase awareness of the vital roles of membranous organelles in cellular physiological and pathological processes through the development of in vivo research systems in model animals, with the focus being on the regulation of intracellular membrane trafficking. The research endeavors to gain new perspectives on developing thorough tactics to oppose the infiltration of intestinal microbes and offers an outline of the study of age-related diseases and the appraisal of anti-aging approaches.