聯系方式：武漢市漢口航空路13#，華中科技大學同濟醫學院基礎2号樓1125室，華中科技大學腦研究所，華中科技大學神經生物學系

工作背景：

2015.03-至今   副教授，華中科技大學同濟醫學院，88858cc永利官网神經生物學系；

2019.09-2021.09 高級訪問學者，美國華盛頓大學醫學院，疼痛中心與麻醉學系；

2016.12-2017.12挂職，科技部中國生物技術發展中心，醫藥處

2011.08-2015.03 博士後，華中科技大學基礎醫學博士後流動站，合作導師為魯友明教授；

2009.09-2010.12 訪問科學家，荷蘭神經科學研究所（NIN）/阿姆斯特丹大學醫學中心(AMC)，研究方向為下丘腦參與外周能量代謝調控的神經機制，合作導師為著名的神經科學家Dick Swaab教授與Andries Kalsbeek教授。

教育背景：

2007.09-2011.06 博士學位，華中科技大學同濟醫學院神經生物學系攻讀細胞與分子神經生物學專業博士，研究方向為疼痛的細胞與分子神經生物學機制，導師為施靜教授；

2004.09-2007.07 碩士學位,華中科技大學同濟醫學院攻讀神經生物學系碩

士，研究方向為炎症性疼痛的細胞與分子機制；

1998.09-2003.07 醫學學士學位，鹹甯醫學院攻讀臨床醫學系本科；

(1) Ke, X, Deng, MF, Wu, Z, Yu, H, Yu, D, Li, H, Lu, Y, Shu, K, Pei, L*. miR‑34b‑3p Inhibition of eIF4E Causes Post‑stroke Depression in Adult Mice. Neurosci. Bull. 2022 July 8 (Online); https://doi.org/10.1007/s12264-022-00898-7. (Co-corresponding author)

(2) Zhang, YF, Ma, SH, Ke, X, Yi, Y, Yu, HY, Yu, D, Li, Q, Shang, Y, Lu, YM, Pei, L*. The mechanism of Annexin A1 to modulate TRPV1 and nociception in dorsal root ganglion neurons. Cell Biosci. 2021 Aug 26;11(1):167. (corresponding author)

(3) Su, TF, Yan, Y, Li, Q, Ye, JC*, Pei, L*. Endocannabinoid System Unlocks the Puzzle of Autism Treatment via Microglia. Front Psychiatry. 2021 Oct 22;12:734837. (Co-corresponding author)

(4) Su, TF, Pei, L*. Acupuncture and oxytocinergic system: The promising treatment for autism. Transl Neurosci. 2021 Feb 16;12(1):96-102. (corresponding author)

(5) Ma, XY, Xiao, WC, Li, H, Pang, P, Xue, FX, Wan, L, Pei, L*, Yan, HH*.Metformin restores hippocampal neurogenesis and learning and memory via regulating gut microbiota in the obese mouse model. Brain Behav Immun. 2021 Jul;95:68-83. (Co-corresponding author)

(6) Wang S, Chen D, Yu J, Wang X, Li Q, Lv F, Shen H, Pei L*. Presynaptic Caytaxin prevents apoptosis via deactivating DAPK1 in the acute phase of cerebral ischemic stroke. Exp Neurol. 2020 Jul;329:113303. (corresponding author)

(7)Cai Y, Zhang Y, Ke X, Guo Y, Yao C, Tang N, Pang P, Xie G, Fang L, Zhang Z, Li J, Fan Y, He X, Wen R, Pei L*, Lu Y*. Transcriptome Sequencing Unravels Potential Biomarkers at Different Stages of Cerebral Ischemic Stroke. Front Genet. 2019 Sep 24;10:814. doi: 10.3389/fgene.2019.00814. (corresponding author)

(8)Guo Y, Li H, Ke X, Deng M, Wu Z, Cai Y, Afewerky HK, Zhang X, Pei L*, Lu Y*. Degradation of Caytaxin Causes Learning and Memory Deficits via Activation of DAPK1 in Aging. Mol Neurobiol. 2019 May;56(5):3368-3379.(corresponding author)

(9)Li SJ, Zhang YF, Ma SH, Yi Y, Yu HY, Pei L*, Feng D*. The role of NLRP3 inflammasome in stroke and central poststroke pain. Medicine (Baltimore). 2018 Aug;97(33):e11861.(corresponding author)

(10)Xiong W, Wu Y, Xian W, Song L, Hu L, Pan S, Liu M, Yao S, Pei L*, Shang Y*. DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells. J Neurol Sci. 2018 Apr 15;387:210-219. (corresponding author)

(11)Song L*, Pei L*, Hu L, Pan S, Xiong W, Liu M, Wu Y, Shang Y, Yao S. Death-associated protein kinase 1 mediates interleukin-1β production through regulating inlfammasome activation in Bv2 microglial cells and mice. Sci Rep. 2018 Jul 2;8(1):9930.

(12)Chen LM, Zhu MX, Zhang YF, Ma SH, Yi Y, Xia LX, Wu Y, Pei L*. A 58-Year

Old Male with Cognitive Deteriorations Caused by Septum Pellucidum Cyst: A Case Report. Front Aging Neurosci. 2017 Sep 13;9:299. doi: 10.3389/fnagi.2017.00299. eCollection 2017. (corresponding author)

(13)Jin HJ*, Pei L*, Li YN*, Zheng H, et al. Alleviative effects of fluoxetine on depressive-like behaviors by epigenetic regulation of BDNF gene transcription in mouse model of post-stroke depression.Sci Rep.2017Nov2;7(1):14926. doi: 10.1038/s41598-017-13929-5.

(14)Song L*, Pei L*, Yao S, Wu Y, Shang Y. NLRP3 Inflammasome in Neurological  

Diseases, from Functions to Therapies. Front Cell Neurosci. 2017 Mar 9;11:63. (Co-first author)

(15) Tang N, Wu J, Zhu H, Yan H, Guo Y, Cai Y, Yan H, Shi Y, Shu S, Pei L*, Lu Y*. Genetic Mutation of GluN2B Protects Brain Cells Against Stroke Damages. Mol Neurobiol. 2017 Apr 29. doi: 10.1007/s12035-017-0562-y. (corresponding author).

(16)Lei Pei, Shan Wang, Jin Huijuan, et al. A Novel Mechanism of Spine Damages in stroke via DAPK1 and Tau. Cereb Cortex. 2015 Nov;25(11):4559-71.

(17)H Jin*, L Pei*, X Shu*, X Yang, T Yan, Y Wu, Na Wei, Honglin Yan, Shan Wang, Chengye Yao, Dan Liu, Qing Tian, Lin Wang, Youming Lu. Therapeutic Intervention of Learning and Memory Decays by Salidroside Stimulation of Neurogenesis in Aging. Molecular Neurobiology, 2016 Mar;53(2):851-66. (Co-first author)

(18)Xiaoxi Wang*, Lei Pei*, Honglin Yan*, Zhongping Wang, Na Wei, Shan Wang, Xin Yang, Qing Tian, and Youming Lu. Intervention of DAPK1-p53 Interaction Exerts the Therapeutic Effects against Stroke. Stroke, 2014 Oct;45(10):3089-91 (Co-first author)

(19)Lei Pei, You Shang, Huijuan Jin, Shan Wang, Na Wei, Honglin Yan, Yan Wu,  

Chengye Yao, Xiaoxi Wang, Ling-Qiang Zhu, and Youming Lu. DAPK1-p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death. The Journal of Neuroscience, 2014, 34(19):6546–6556.

(20)Lizhao Wang, Dan Feng, Huanhuan Yan, Zhongping Wang, Lei Pei*. The Comparative Analysis of P2X1, P2X2, P2X3 AND P2X4 Receptor Subunits in Rat Nodose Ganglion Neurons. PLoS ONE 9(05): e96699, doi:10.1371/journal.pone.0096699 (corresponding author).

(21)L Chen, F Lv, L Pei*. Annexin 1: a glucocorticoid-inducible protein that modulates inflammatory pain. European Journal of Pain, 18 (2014) 338–347 (corresponding author).

(22)L Chen, M Jiang, L Pei*. Comparison of Three Method s of Drug Delivery in the

Rat Lumbar Spinal Subarachnoid Space. THE ANATOMICAL RECORD 2012, 295:1212–1220 (corresponding author).

(23)L Pei, J Zhang, F Zhao, T Su, H Wei, J Tian, M Li, J Shi. Annexin 1 exerts anti-nociceptive effects through formyl-peptide-receptor-like 1 in rat dorsal root ganglion after peripheral inflammatory pain. British Journal of Anaesthesia 2011, 107(6): 948-958.

(24)L Pei, C Lin, J Dai, G Yin. Facial pain induces the alteration of transient receptor potential vanilloid receptor 1 expression in rat trigeminal ganglion, Neuroscience Bulletin 2007, 23(2): 92-100.

Co-author Publications

(1)Li X, Chen W, Pan K, Li H, Pang P, Guo Y, Shu S, Cai Y, Pei L, Liu D, Afewerky HK, Tian Q, Zhu LQ, Lu Y. Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus. Nat Neurosci. 2018 Sep;21(9):1239-1250.

(2)Tuo QZ, Liuyang ZY, Pei L, Yan X, Shentu YP, Liang JW, Zhou H, Pei L, Xiong Y, Hou TY, Zhou XW, Wang Q, Wang JZ, Wang XC, Liu R. Zinc induces CDK5 activation and neuronal death through CDK5-Tyr15 phosphorylation in ischemic stroke. Cell Death Dis. 2018 Aug 29;9(9):870.

(3)Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ, Lu Y. Synaptic mechanism in Alzheimer’s disease: a selective degeneration of an excitatory synaptic pathway in the CA1 hippocampus that controls spatial learning and memory in Alzheimer’s disease. Mol Psychiatry. 2018 Feb;23(2):167.

(4)Zhu H, Yan H, Tang N, Li X, Pang P, Li H, Chen W, Guo Y, Shu S, Cai Y, Pei L, Liu D, Luo MH, Man H, Tian Q, Mu Y, Zhu LQ, Lu Y. Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapses. Nat Commun. 2017 Nov 22;8(1):1676. doi: 10.1038/s41467-017-01943-0.

(5)Bi LL, Chen M, Pei L, Shu S, Jin HJ, Yan HL, Wei N, Wang S, Yang X, Yan HH, Xu MM, Yao CY, Li N, Tang N, Wu JH, Zhu HZ, Li H, Cai Y, Guo Y, Shi Y, Tian Q, Zhu LQ, Lu YM.Infralimbic Endothelin1 Is Critical for the Modulation of Anxiety-Like Behaviors. Mol Neurobiol. 2016 Apr;53(3):2054-2064.

(6)Zhang T, Pang P, Fang Z, Guo Y, Li H, Li X, Tian T, Yang X, Chen W, Shu S, Tang N, Wu J, Zhu H, Pei L, Liu D, Tian Q, Wang J, Wang L, Zhu LQ, Lu Y. Expression of BC1 Impairs Spatial Learning and Memory in Alzheimer's Disease Via APP Translation. Mol Neurobiol. 2017 Nov 13. doi: 10.1007/s12035-017-0820-z.

(7)Wang S, Shi X, Li H, Pang P, Pei L, Shen H, Lu Y. DAPK1 Signaling Pathways in Stroke: from Mechanisms to Therapies. Mol Neurobiol. 2017 Aug;54(6):4716-4722.

(8) Yan H, Pang P, Chen W, Zhu H, Henok K A, Li H, Wu Z, Ke X, Wu J, Zhang T, Pan K, Pei L, Han Y, Lu Y. The Lesion Analysis of Cholinergic Neurons in 5XFAD Mouse Model in the Three-Dimensional Level of Whole Brain. Mol Neurobiol. 2017 Jul 7. doi: 10.1007/s12035-017-0672-6.

(9) Shu S, Zhu H, Tang N, Chen W, Li X, Li H, Pei L, Liu D, Mu Y, Tian Q, Zhu LQ, Lu Y. Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer's Disease via Activation of DAPK1. J Neurosci. 2016 Oct 19;36(42):10843-10852.

(10) Xian W, Wu Y, Xiong W, Li L, Li T, Pan S, Song L, Hu L, Pei L, Yao S, Shang Y. The pro-resolving lipid mediator Maresin 1 protects against cerebral ischemia/reperfusion injury by attenuating the pro-inflammatory response. Biochem Biophys Res Commun. 2016 Mar 25;472(1):175-81.

(11) Li L, Wu Y, Wang Y, Wu J, Song L, Xian W, Yuan S, Pei L, Shang Y. Resolvin D1 promotes the interleukin-4-induced alternative activation in BV-2 microglial cells. J Neuroinflammation. 2014 Apr 5;11:72. doi: 10.1186/1742-2094-11-72.

(12)K Zhao, R Wen, X Wang, Pei L, Y Yang, Y Shang, N Bazan, L Zhu, Q Tian, and Y Lu. EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability. The Journal of Neuroscience, 2013, 33(20): 8861-8865.

(13)Y Yang, X Shu, D Liu, Y Shang, Y Wu, Pei L, X Xu, Q Tian, K Qian, Y Wang, R S. Petralia, W Tu, L Zhu, J Wang, Y Lu. EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation, Neuron 2012, 73(4):774-778.

(14)E Bruinstroop, Pei L, M T Ackermans, E Foppen, A J Borgers, J Kwakkel, A Alkemade, E Fliers, A Kalsbeek. Hypothalamic neuropeptide Y (NPY) controls hepatic VLDL-triglyceride secretion in rats via the sympathetic nervous system, Diabetes 2012, 61(5):1043-1050.

(15) A Alkemade, C Yi, Pei L, M Harakalova, D F Swaab, S E la Fleur, E Fliers, A Kalsbeek. AgRP and NPY expression in the human hypothalamic infundibular nucleus correlate with body mass index, whereas changes in MSH are related to type 2 diabetes, The Journal of Clinical Endocrinology & Metabolism 2012, 97(6):E925-33.

(16) J Zhang, F Zhao, Y Zhao, J Wang, L Pei, N Sun, J Shi. Hypoxia induces an increase in intracellular magnesium via TRPM7 channels in rat hippocampal neurons in vitro, The Journal of biological chemistry 2011, 286(23):0194-20207.

(17) TF Su, YQ Zhao, LH Zhang, M Peng, CH Wu, L Pei, B Tian, J Zhang, J Shi, HL Pan, M Li Electroacupuncture Reduces the Expression of Proinflammatory Cytokines in Inflamed Skin Tissues through Activation of Cannabinoid CB2 Receptors, European journal of pain 2011, 7(1): 98.

(18) J Zhang, L Chen, T Su, F Cao, X Meng, L Pei, J Shi, HL Pan, M Li. Electroacupuncture increases CB2 receptor expression on keratinocytes and infiltrating inflammatory cells in inflamed skin tissues of rats, The Journal of Pain 2010, 11(12), 1250-1258.

(19) W Fu, J Chen, Y Cai, Y Lei, L Chen, L Pei, D Zhou, X Liang, J Ruan. Antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective potential of the extract from Parathelypteris nipponica Ching, Journal of Ethnopharmacology 2010, 130 (3): 521-528.

(20) H Liu, Z Li, M Yang, X Tian, L Pei, C Li. Sensory innervation of the anterior eye segment in rats: a retrograde tracing study. FRONTIERS OF MEDICINE IN CHINA 2009, 3 (3): 352-356.

(21) Jiang Q, Wang L, Guan Y, Xu H, Niu Y, Han L, Wei YP, Lin L, Chu J, Wang Q, Yang Y, L Pei, Wang JZ, Tian Q. Golgin-84-associated Golgi fragmentation triggers tau hyperphosphorylation by activation of cyclin-dependent kinase-5 and extracellular signal-regulated kinase. Neurobiol Aging. 2014 Jun;35(6):1352-63.

專利

(1) 張玉芬; 馬瑟惠; 柯霄; 餘鴻雁; 餘點; 尚遊; 裴磊; 魯友明 ; 一種大鼠腦内自由給藥及采血裝置,2020-05-15, 中國, ZL 2019 2 0852792.3

(2)旺姗,裴磊,顔歡歡,郭豫,李浩,唐娜,龐培,魯友明; 一種小分子多肽、其應用及産品. 2015.04.08, CN201410734580.7

(3)李熳,潘曉莉,王俊俊,劉雙喜,張力,宋元龍,郭樂江,裴磊. 一種臨床用肌電測痛裝置，2015.7.1，中國，ZL 2014 2 0865547.3；

(4)魯友明,裴磊,朱鈴強,徐傳瑞. 小分子多肽TAT-p53DM及其在制備治療或預防缺血性卒中藥物中的應用,2015.10.28,中國，ZL 2014 1 0141844.8;

(5)裴磊, 施靜. 簡易熱機械兩用測痛儀（ZL 2009 20154972.0 CN201533832U）

主持科研項目

（1）華中科技大學自主創新研究基金項目《缺血性卒中後DAPK1通過Caytaxin介導突觸前損傷的機制研究》（5萬元）（已結題）

（2）中荷合作項目《下丘腦參與外周能量代謝調控的神經機制（09CDP022）研究》（1.95萬歐元）（已結題）

（4）中國博士後科學基金面上項目一等資助（Annexin1-FPR2/ALX通路抑制TRPV1作用機制研究）（2013M530345）(8萬元) （已結題）

（5）中國博士後科學基金面上項目一等資助（DAPK1-Tau相互作用介導突觸損傷的機制研究） （2013M540583）(8萬元) （已結題）

（6）國家自然科學基金青年研究項目<Annexin1 調節瞬時感受器電位香草素受體1 敏感性介導抗炎症痛的機制研究>（81200863）（23萬元）（已結題）

（7）國家自然科學基金面上研究項目<死亡相關蛋白激酶1介導皮層丘腦環路損傷引起卒中後疼痛的機制研究>（81571078）（57萬元）

（8）國家自然科學基金面上研究項目<死亡相關蛋白激酶1損傷海馬前額葉皮層環路介導卒中後抑郁的機制研究>（81870932）（56萬元）

參與學術活動 （會議）

(1) 中英學術大講堂（一）

(2) 2020科學編輯理事會年會 （2020 CSE Virtual Annual Meeting (CSE2020)），美國聖路易斯華盛頓大學醫學院（WUSTL），2020年5月4日，How to survive and thrive in the research environment and system in China: an experience of a medical scientist.口頭報告。

(3)第38屆日本神經科學年會 (the 38th Annual Meeting of the Japanese Neuroscience Society)，日本神戶國際會議中心，2015年 7月28-31日，Cerebrovascular Disease and Ischemia Session, 2007-2-3(17:00),口頭報告。

獲獎情況：

2014年 IBRO國際腦研究組織 Travel Grant

2015年 德國神經科學學會GNS Travel Grant (Stipend for the 11th Göttingen Meeting of the German Neuroscience Society 2015)

2015年 第38屆日本神經科學年會Travel Awards (Travel Awards for the 38th Annual Meeting of the JNS)

2015年 中國神經科學學會賽諾菲優秀會議論文獎

2016年 湖北省科學協會第16屆自然科學優秀論文一等獎