李傳洲

專業方向：神經退行性疾病機理

• 個人簡介：2007年武漢大學生科院獲學士學位；2012年武漢大學獲得細胞生物學博士學位；2013-2018年澳大利亞昆士蘭腦研究所從事博士後研究。2018年4月入職88858cc永利官网醫學遺傳系，博士生導師，研究方向為神經退行性疾病緻病機理。包括：1）阿爾茨海默病（AD）中微管結合蛋白Tau和激酶Fyn的相互調控機理；2）Tau蛋白在胞體樹突中形成神經纖維纏結的機制；3）FUS基因突變導緻肌萎縮側索硬化（ALS/漸凍症）的緻病機理。近年來在Neuro-Oncology、Biomark Res、Ann Clin Transl Neur、Front Neurol、Front Neurosci、Front Genet發表通訊作者論文；唯一第一作者J Azheimers Dis、EMBO J封面文章、Nat. Rev. Drug. Discov封面文章；獲得華中科技大學自主創新基金、國家自然科學基金青年項目和面上項目支助；擔任‘Oncogene’‘Journal of Neurochemistry’‘Pharmaceutical Research’ ‘Scientific Reports’‘Neural Regeneration Research’ ‘International Journal of Biological Sciences’ ‘Biological research’ ‘Aging’ ‘Cellular and Molecular Life Sciences’ ‘Front. Neuro’ ‘Front. Neurosci.’等雜志評審專家，Gene Expression雜志編委，Current Medical Science雜志青年編委；多種教育部省科技廳項目論文評審專家以及101教育部醫學分子遺傳學教材編委。

聯系方式：chuanzhouli@hust.edu.cn

地址：同濟醫學院88858cc永利官网2号樓1220室

Liu, D., H. Zhu, L. Cheng, R. Li, X. Ma, J. Wang, J. Wang, S. Zhang, Y. Li, K. Shu, X. Yu andC. Li(2023). "Hypoxia induced Galectin-8 maintains stemness in glioma stem cells via autophagy regulation."Neuro-Oncology.通訊

Liu, D., Zhu, H., andLi, C.(2023). Galectins and galectin-mediated autophagy regulation: new insights into targeted cancer therapy.Biomark Res11, 22.通訊

Li, Y., J. Xu, Y. Xu,C. Li, Y. Wu and Z. Liu (2023). "Clinical, genetic, and molecular characteristics in a central-southern Chinese cohort of genetic leukodystrophies."Ann Clin Transl Neurol.共通訊

Liang, Z., Y. Wu,C. Liand Z. Liu (2023). "Clinical and genetic characteristics in a central-southern Chinese cohort of early-onset Alzheimer's disease."Front Neurol14: 1119326.共通訊

Zhao, L., F. Meng, Y. Li, S. Liu, M. Xu, F. Chu,C. Li,X. Yang and L. Luo (2023). "Multivalent Nanobody Conjugate with Rigid, Reactive Oxygen Species Scavenging Scaffold for Multi-Target Therapy of Alzheimer's Disease."Adv Mater:e2210879.

Zhang J, Hu C, Xie X, Qi L, Li C*, Li S*. (2023). Immune Checkpoint Inhibitors in HBV-Caused Hepatocellular Carcinoma Therapy.Vaccines.; 11(3):614.共通訊

Chu, F., Xu, J., Wang, Y., Li, Y., Wang, Y., Liu, Z., andLi, C.(2022). Novel mutations in GJB1 trigger intracellular aggregation and stress granule formation in X-linked Charcot-Marie-Tooth Disease.Front Neurosci16, 972288.通訊

Tian, H., Chu, F., Li, Y., Xu, M., Li, W., andLi, C. (2022). Synergistic effects of rare variants of ARHGAP31 and FBLN1 in vitro in terminal transverse limb defects.Front Genet13, 946854.通訊

Wang, W., Li, J., Tan, J., Wang, M., Yang, J., Zhang, Z.M.,Li, C., Basnakian, A.G., Tang, H.W., Perrimon, N., and Zhou, Q. (2021). Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response.Nat Commun12, 476.

Polanco, J.C., Hand, G.R., Briner, A.,Li, C., and Gotz, J. (2021). Exosomes induce endolysosomal permeabilization as a gateway by which exosomal tau seeds escape into the cytosol.Acta Neuropathol141, 235-256.

餘裕龍,周珂如,李傳洲, and陳娟(2020).精神分裂症斷裂基因１參與線粒體動力學調控的研究進展.華中科技大學學報（醫學版）49, 98.

Chen, Y., Sun, T., Niu, Y., Wang, D., Xiong, Z.,Li, C., Liu, K., Qiu, Y., Sun, Y., Gong, J., Wang, T., Wang, S., Xu, H., and Liu, J. (2020). Correlations Among Genotype and Outcome in Chinese Male Patients With Congenital Hypogonadotropic Hypogonadism Under HCG Treatment.J Sex Med17, 645-657.

Li, C., Briner, A., and Gotz, J. (2019). The search for improved animal models of Alzheimer's disease and novel strategies for therapeutic intervention.Future Med Chem11, 1853-1857.

Li, C. and J. Götz, Pyk2 is a Novel Tau Tyrosine Kinase that is Regulated by the Tyrosine Kinase Fyn.J Alzheimers Dis,2018. 64(1): p. 205-221.（受Fyn調控的新型Tau酪氨酸激酶Pyk2；唯一第一作者；雜志網頁推薦文章；影響因子3.92）

Polanco, J.C.,Li, C.Durisic, N. Sullivan, R. Götz, J. et al., Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons.Acta Neuropathol Commun, 2018. 6(1): p. 10.（影響因子5.414）

Polanco, J.C.,Li, C., Bodea L.G., Marmol, R.M., Meunier, F., and Götz, J. (2017) Amyloid-beta and tau complexity - towards improved biomarkers and targeted therapies.Nat Rev Neurol, 2018. 14(1): p. 22-39.（β澱粉樣蛋白和tau的多态性—更好生物标志物和靶向治療；影響因子20.2）

Li, C.and J. Gotz (2017). "Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation."EMBO Journal36(21): 3120-3138.（阿爾茲海默症中Fyn介導的局部蛋白質合成促進了Tau在胞體樹突的聚集；唯一第一作者；影響因子9.792；權威學術論壇Alzforum對此發表長篇評論；雜志封面）

Li, C. and J. Gotz (2017). "Tau-based therapies in neurodegeneration: opportunities and challenges."Nat Rev Drug Discov16(12): 863-883.（以Tau為基礎的神經退行性疾病的多元化靶向治療；唯一第一作者；影響因子57）

Xia, D.,Li, C., and Götz, J. (2015). "Pseudophosphorylation of Tau at distinct epitopes or the presence of the P301L mutation targets the microtubule-associated protein Tau to dendritic spines."Biochim. Biophys. Acta. 1852(5): 913-924.（影響因子5.725）

Li, C., Wang, L., and Zheng, L. (2012). "Endoplasmic reticulum stress in retinal vascular degeneration: protective role of resveratrol."Invest. Ophthalmol. Vis. Sci.53(6): 3241-3249. (眼科研究型雜志中排名第一;影響因子3.427）

Li, C., Wang, L., Huang, K., and Zheng, L. (2012). "Inhibition of poly(ADP-ribose) polymerase inhibits ischemia/reperfusion induced neurodegeneration in retina via suppression of endoplasmic reticulum stress."Biochem. Biophys. Res. Commun. 423(2):276-281.（影響因子：2.5559）

Wang, L.,Li, C., Guo, H., Kern, T.S., Huang, K., and Zheng, L. (2011). Curcumin inhibits neuronal and vascular degeneration in retina after ischemia and reperfusion injury.PLoS ONE6(8):e23194.（影響因子：2.766）

Sullivan, M.A., Li, J.,Li, C., Vilaplana, F., Stapleton, D., Gray-Weale, A.A., Bowen, S., Zheng, L., and Gilbert ,R.G. (2011). Molecular structural differences between type-2-diabetic and healthy glycogen.Biomacromolecules12(6):1983-1986.（影響因子：5.246）

Gong, H., Zhang, X., Cheng, B., Sun, Y.,Li, C., Li, T., Zheng, L., and Huang, K. (2013). "Bisphenol a Accelerates Toxic Amyloid Formation of Human Islet Amyloid Polypeptide: A Possible Link between Bisphenol a Exposure and Type 2 Diabetes."PLoS One8, no. 1:e54198.（影響因子：2.766）

Cheng, B., Liu, X., Gong, H., Huang, L., Chen, H., Zhang, X.,Li, C., Yang, M., Ma, B., Jiao, L., Zheng, L. and Huang, K. (2011). Coffee Components Inhibit Amyloid Formation of Human Islet Amyloid Polypeptide in Vitro: Possible Link between Coffee Consumption and Diabetes Mellitus.J. Agric. Food Chem.59(24):13147-13155.（影響因子：3.154）

Zhang, X., Cheng, B., Gong, H.,Li, C., Chen, H., Zheng, L., and Huang, K. (2011). Porcine islet amyloid polypeptide fragments are refractory to amyloid formation.FEBS Lett585(1):71-77.（影響因子：2.999）