郭峥

華中科技大學

同濟醫學院基礎醫學院醫學遺傳學系

• 88858cc永利官网教授，博導

• 醫學遺傳系，主任

• 實驗室網頁：http://www.guozhenglab.net

聯系地址：

湖北省武漢市硚口區航空路13号同濟醫學院形态學樓102室

聯系方式：

電話:86(27)13545037970

郵箱: guozheng@hust.edu.cn

教育經曆：

2004-2011,中國科學院遺傳與發育生物學研究所，發育生物學博士學位

2000-2004， 中央民族大學生命科學專業，理學學士

工作經曆：

2016-至今,教授、醫學遺傳學系系主任華中科技大學同濟醫學院88858cc永利官网

2011-2016,博士後，美國哥倫比亞大學醫學院遺傳與發育生物學系。

實驗室研究領域及内容:

目前實驗室利用果蠅為模式動物，對腸道幹細胞的多功能分化進行深入研究，以期理解幹細胞分化的内在生理邏輯和分子基礎，以達到對癌症以分化為導向的轉化醫學治療。主要研究内容為：1）腸道表皮幹細胞數目的決定機制；2）腸道表皮幹細胞位置的決定機制；3）腸道幹細胞分化過程中Notch信号激活強弱的控制機制；4)腸道幹細胞多功能分化的子代細胞比例控制機制。文章發表在Science,DevelopmentalCell，NatureCommunications，The Journal ofCell Biology,CellReports，Development,CommunicationsBiology等國際著名雜志。

研究論文：

1.Zhang, S., Wu, S., Yao, R.N., Wei, X.Y., Ohlstein, B., andGuo, Z.(2024). Eclosion muscles secrete ecdysteroids to initiate asymmetric intestinal stem cell division in. Developmental cell59. 10.1016/j.devcel.2023.11.016.

2.Gao, J., Zhang, S., Deng, P., Wu, Z., Lemaitre, B., Zhai, Z., andGuo, Z.(2024). Dietary L-Glu sensing by enteroendocrine cells adjusts food intake via modulating gut PYY/NPF secretion. Nature communications15, 3514. 10.1038/s41467-024-47465-4.

3.Wu, S., Yang, Y., Tang, R., Zhang, S., Qin, P., Lin, R., Rafel, N., Lucchetta, E.M., Ohlstein, B., andGuo, Z.(2023). Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold. Cell reports42, 112093. https://doi.org/10.1016/j.celrep.2023.112093.

4.Wu, S., Tang, R., Ohlstein, B., andGuo, Z.(2023). A live-imaging protocol for tracking intestinal stem cell divisions in the Drosophila melanogaster pupal midgut. STAR protocols4, 102749. 10.1016/j.xpro.2023.102749.

5.Wang, B., Gao, J., Jiang, J., Hu, Z., Hjort, K.,Guo, Z., and Wu, Z. (2021). Liquid Metal Microscale Deposition enabled High Resolution and Density Epidermal Microheater for Localized Ectopic Expression inDrosophila. Advanced Materials Technologies, 2100903. 10.1002/admt.202100903.

6.Tang, R., Qin, P., Liu, X., Wu, S., Yao, R., Cai, G., Gao, J., Wu, Y., andGuo, Z.(2021). Intravital imaging strategy FlyVAB reveals the dependence of Drosophila enteroblast differentiation on the local physiology. Communications biology4, 1223. 10.1038/s42003-021-02757-z.

7.Guo, Z., Lucchetta, E., Rafel, N., and Ohlstein, B. (2016). Maintenance of the adult Drosophila intestine: all roads lead to homeostasis. Current opinion in genetics & development40, 81-86. 10.1016/j.gde.2016.06.009.

8.Guo, Z., and Ohlstein, B. (2015). Stem cell regulation. Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency. Science350. 10.1126/science.aab0988.

9.Guo, Z., Driver, I., and Ohlstein, B. (2013). Injury-induced BMP signaling negatively regulates Drosophila midgut homeostasis. The Journal of cell biology201, 945-961. 10.1083/jcb.201302049.

10.Guo, Z., and Wang, Z. (2009). The glypican Dally is required in the niche for the maintenance of germline stem cells and short-range BMP signaling in the Drosophila ovary. Development136, 3627-3635. 10.1242/dev.036939.

獲得榮譽：

第十三批中組部“千人計劃”青年項目。

獲得資助:

自然科學基金委面上項目三項，實驗室博士後獲得自然科學基金委青年基金一項，國家博士後基金一項。

教授課程：

1001101細胞生物學Cell Biology(本科)

1001121醫學遺傳學Medical Genetics (本科、碩士)

510.543醫學遺傳學進展Advances in Medical Genetics (碩士)

510.805醫學遺傳學進展Advanced Medical Genetics (博士)

510.816 Dysfunction of Receptors and Ion Channels in Neurological Disease (博士)

在研課題：

1. Determine the mechanism of the“differentiation toggle” in Drosophila ISCs.

2.Determine the mechanism of high-low Notch signaling establishment.

3.To determine whether mammalian intestinal stem cells use the same bidirectional Notch signaling to regulate multipotency.