方敏

作者：admin 時間：2017-06-06 點擊量：次

方敏，男，1966年1月出生，中共黨員，免疫學專業博士，華中科技大學同濟醫學院免疫學系三級教授，博士/碩士研究生導師。1983年9月-1989年7月在武漢同濟醫科大學本科學習，獲醫學學士學位；1993年9月-1996年7月在武漢同濟醫科大學攻讀碩士學位，獲免疫學專業碩士學位；2002年5月—2005年5月：德國杜塞爾多夫大學攻讀博士學位，獲免疫學專業博士學位。1996年7月—1999年8月：武漢同濟醫科大學88858cc永利官网免疫學教研室助教，講師；1999年8月—2000年8月：維也納大學醫學院外科研究所訪問學者。2005年5月-2010年10月：華中科技大學同濟醫學院免疫學教研室副教授。2010年11月-迄今：華中科技大學同濟醫學院免疫學教研室教授。中國免疫學會移植免疫分會委員，中德醫學會會員。主要研究方向為免疫耐受與移植免疫學;參與完成科技部重大基礎研究項目（973項目）2項；作為項目負責人已完成國家自然科學基金二項(2008.1-2010.12)：（Grant No.30772039）SOCS與IDO對移植排斥反應中Th17細胞的調節機制; (Grant No. 81072440) HMGB1誘生、趨化IL-17+γδT/Th17細胞參與移植排斥反應的作用與機制。目前作為項目負責人承擔國家自然科學基金二項：2014.1-2017.12(Grant No. 81373167）； 2016-2018（Grant No. 91542110）。以第一作者和通訊作者發表SCI論文22篇。

近期已發表主要論著(* 為通訊作者)：

1. Chen X, Fang D, Li L, Chen L, Li Q, Gong F, Fang M*.Glycyrrhizin ameliorates experimental colitis through attenuating interleukin-17-producing T cell responses via regulating antigen-presenting cells. Immunol Res. 2017 ;65(3):666-680.

2. Chen X, Li L, Khan MN, Shi L, Wang Z, Zheng F, Gong F, Fang M*. HMGB1 exacerbates experimental mouse colitis by enhancing innate lymphoid cells 3 inflammatory responses via promoted IL-23 production. Innate Immunity. 2016 Nov;22(8):696-705.

3. Qin Xu, Fang Zheng, Feili Gong, and Min Fang*. Suppressor of cytokine signaling 3 (SOCS3) gene transfer prolongs the survival of murine cardiac allograft by attenuating IL-17-producing alloreactive T-cell responses. The Journal of Gene Medicine 2014；16: 66-74

4. Xia Q, Duan L, Shi L, Zheng F, Gong F, Fang M*. High-mobility group box 1 accelerates early acute allograft rejection via enhancing IL-17+ γδ T-cell response.Transplant International 2014；27: 399-407

5．Xiong A, Duan L, Chen J, Fan Z, Zheng F, Tan Z, Gong F*, Fang M*. Flt3L combined with rapamycin promotes cardiac allograft tolerance by inducing regulatory dendritic cells and allograft autophagy in mice.PLoS One. 2012; 7(10):e46230. doi: 10.1371/journal.pone.0046230.

6. Chen J, Duan L, Xiong A, Zhang H, Zheng F, Tan Z, Gong F, Fang M. Blockade of IL-33 ameliorates Con A-induced hepatic injury by reducing NKT cell activation and IFN-γ production in mice. J Mol Med. 2012; 90 (12):1505-1515.

7.Duan L, Chen J, Zhang H, Yang H, Zhu P, Xiong A, Xia Q, Zheng F, Tan Z, Gong F, Fang M. Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3⁺ regulatory T-cell responses in mice Mol Med. 2012; 18:753-761.

8. Zhu P., Duan L., Chen J., Xiong A.,Xu Q., Zhang H.，Zheng F., Tan Z., Gong F.*, Fang M.*. Gene silencing of NALP3 protects against liver ischemia-reperfusion injury in mice. Human Gene Therapy 2011；22:853-864.

9. Duan L, Wang CY, Chen J, Gong Q, Zhu P, Zheng F, Tan Z, Gong F*, Fang M*. High-mobility group box 1 promotes early acute allograft rejection by enhancing IL-6-dependent Th17 alloreactive response. Laboratory Investigation 2011；91: 43-53.

10. Tong J, Wu WN, Kong X, Wu PF, Tian L, Du W, Fang M, Zheng F, Chen JG*, Tan Z*, Gong F*.Acid-sensing ion channels contribute to the effect of acidosis on the function of dendritic cells. J Immunol. 2011, 186: 3686-3692.

11. Li Liu, Lihua Duan, Min Gong, Hong Dai, Quan Gong, Fang Zheng, Zheng Tan, Cong-Yi Wang, Feili Gong, Min Fang^*. Indoleamine 2,3 dioxygenase and regulatory dendritic cells contribute to the allograft protection by infusion of donor-specific splenic stromal cells. Cellular & Molecular Immunology 2011； 8: 31-40.

12. Quan Gong, Hui Zhang, Jun-hua Li, Li-hua Duan, Shan Zhong, Xiao-ling Kong, Fang Zheng, Zheng Tan, Ping Xiong, Gang Chen, Min Fang^,*, Fei-li Gong^,*High-mobility group box 1 exacerbates concanavalin A induced hepatic injury in mice. J. Mol. Med. 2010；88：1289-1298.

13．Zhang H., Gong Q., Li J.H., Kong X.L., Tian L., Duan L.H., Tong J., Song F.F., Fang M., Zheng F., Xiong P., Tan Z., Gong F.L., CpG ODN pretreatment attenuates concanavalin A-induced hepatitis in mice. International Immunopharmacology 2010, 10:79-85.

14. Ma Y., Yang H., Qi J., Liu D., Xiong P., Xu Y., Feng W., Zheng G., Li P., Fang M., Tan Z., Zheng F., Gong F., CD2AP is indispensable to multistep cytotoxic process by NK cells. Mol. Immunol. 2010, 47:1074-82.

15．Dai H., Zhu H., Lei P., Yagita H., Liu J., Wen X., Zhou W., Gong F., Shen G.^*, FangM.^*, Programmed death-1 signaling is essential for the skin allograft protection by alternatively activated dendritic cell in fusion in mice. Transplantation 2009, 88:864-873.

16. Yu G., Dai H., Chen J., Duan L., Gong M., Liu L., Xiong P., Wang C.-Y. , Fang M.* and Gong F.*, Gene delivery of IDO prolongs cardiac allograft survival by shaping the types of T-cell responses. J. Gene Med. 2008, 10: 754-761.

17. Yu G., Fang M.*, Gong M., Liu L., Zhong J., Feng W., Xiong P., Cong-Yi Wang C.-Y., and Gong F.*. Steady state dendritic cells with forced IDO expression induce skin allograft tolerance by upregulation of regulatory T cells. Transplant Immunology 2008, 18: 208-219.

18. Gong Q., Yin H., Fang M., Xiang Y., Yuan C.L., Zheng G.Y., Yang H., Xiong P., Chen G.*, Gong F.L.*, Zheng F., Heme oxygenase-1 upregulation significantly inhibits TNF-α and Hmgb1 releasing and attenuates lipopolysaccharide-induced acute lung injury in mice. International Immunopharmacology 2008, 8:792–798.

19.Huang Y.F., Yin H., Han J.Y., Huang B.J.,Xu J.F., Zheng F., Fang M., Wang C.-Y., Gong F.L.,Extracellular Hmgb1 functions as an innate immune mediator implicated in murine cardiac allograft acute rejection. American Journal of Transplantation 2007, 7: 293-302.

20. Xu J.F., Huang B.J., Yin H., Xiong P., Feng W., Xu Y., Fang M., Zheng F., Wang C.-Y.,Gong F.L., A limited course of soluble CD83 delays acute cellular rejection of MHC-mismatched mouse skin allograft. Transplant international 2007, 20 :266-276.

21. Huang B.J., Yin H., Huang Y.F., Xu J.F., Xiong P., Feng W., Zheng F., Xu Y., Fang M., Gong F.L. Gene therapy using adenoviral vector encoding 4-1 BBIg gene significantly prolonged murine cardiac allograft survival. Transplant Immunology 2006，16:88-94.

22. Fang M., Dai H., Yu G. Gong F-L., Gene delivery of SOCS3 protects mice from lethal endotoxic shock. Cellular & Molecular Immunology 2005，2：373-377.

上一篇：付琴

4. Xia Q, Duan L, Shi L, Zheng F, Gong F, Fang M*. High-mobility group box 1 accelerates early acute allograft rejection via enhancing IL-17+ γδ T-cell response.Transplant International 2014；27: 399-407

6. Chen J, Duan L, Xiong A, Zhang H, Zheng F, Tan Z, Gong F*, Fang M*. Blockade of IL-33 ameliorates Con A-induced hepatic injury by reducing NKT cell activation and IFN-γ production in mice. J Mol Med. 2012; 90 (12):1505-1515.

7.Duan L, Chen J, Zhang H, Yang H, Zhu P, Xiong A, Xia Q, Zheng F, Tan Z, Gong F*, Fang M*. Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3⁺ regulatory T-cell responses in mice Mol Med. 2012; 18:753-761.

6. Chen J, Duan L, Xiong A, Zhang H, Zheng F, Tan Z, Gong F, Fang M. Blockade of IL-33 ameliorates Con A-induced hepatic injury by reducing NKT cell activation and IFN-γ production in mice. J Mol Med. 2012; 90 (12):1505-1515.

7.Duan L, Chen J, Zhang H, Yang H, Zhu P, Xiong A, Xia Q, Zheng F, Tan Z, Gong F, Fang M. Interleukin-33 ameliorates experimental colitis through promoting Th2/Foxp3⁺ regulatory T-cell responses in mice Mol Med. 2012; 18:753-761.