個人簡介

陳宏生，碩士生導師。2013年畢業于華中科技大學，獲理學學士學位。2018年畢業于華中科技大學同濟醫學院，獲醫學博士學位。2018至2023年，于華中科技大學88858cc永利官网進行博士後研究。2023年4月入職88858cc永利官网藥理學系。

主要從事創傷後應激障礙、抑郁症、焦慮症等負性情感障礙的分子機制和藥物靶點研究。以第一、共同第一作者在Science Advances、Biological Psychiatry、Brain Behavior and Immunity、Current Opinion in Neurobiology等雜志發表論文多篇。作為負責人主持國家自然科學基金2項，中國博士後科學基金面上項目1項。相關工作獲華夏醫學科技進步獎（6/10）。

聯系方式：QQ：421206625

E-mail：chenhongsheng1991@163.com

主要研究項目：

1. 國家自然科學基金面上基金項目，82473902，氯胺酮長效抗抑郁作用新機制：Neurobeachin驅動的突觸後膜受體循環途徑，主持

2. 國家自然科學基金青年科學基金項目，81903593，前額皮層LncRNA-GM2694/HSP70通路調控抑郁症的機理研究，主持

3. 中國博士後科學基金面上資助，2019M652657，LncRNA GM2694損傷突觸可塑性介導抑郁症發病，主持

4. 華中科技大學技術創新基金，AMPA受體的膜穩定性對創傷後應激障礙的作用及機制，主持

近5年代表性學術論文:

1. Hong-Sheng Chen^(#), Fang Wang, Jian-Guo Chen^(*).Epigenetic mechanisms in depression: Implications for pathogenesis and treatment.Curr Opin Neurobiol.2024 Apr:85:102854.

2. Kai-Yu Zheng^(#), Bo Gao^(#), Hua-Jie Wang,Jin-Gang He,Hong-Sheng Chen, Zhuang-Li Hu, Li-Hong Long, Jian-Guo Chen^(*), Fang Wang^(*). Melatonin Ameliorates Depressive-Like Behaviors in Ovariectomized Mice by Improving Tryptophan Metabolism via Inhibition of Gut Microbe Alistipes Inops.Adv Sci (Weinh).2024 Sep;11(34):e2309473.

3. Ji Wang^(#),Hong-Sheng Chen^(#), Hou-Hong Li, Hua-Jie Wang, Ruo-Si Zou, Xiao-Jia L, Jie Wang , Bin-Bin Nie, Jin-Feng Wu, Shuang Li , Bao-Ci Shan, Peng-Fei Wu, Li-Hong Long, Zhuang-Li Hu^(*), Jian-Guo Chen^(*), Fang Wang^(*).Microglia-dependent excessive synaptic pruning leads to cortical underconnectivity and behavioral abnormality following chronic social defeat stress in mice.Brain Behav Immun.2023 Mar:109:23-36.

4. Hou-Hong Li^(#), Yang Liu^(#),Hong-Sheng Chen, Ji Wang, Yu-Ke Li, Yang Zhao, Rui Sun, Jin-Gang He, Fang Wang^(*), Jian-Guo Chen^(*).PDGF-BB-Dependent Neurogenesis Buffers Depressive-Like Behaviors by Inhibition of GABAergic Projection from Medial Septum to Dentate Gyrus.Adv Sci (Weinh). 2023 Aug;10(22):e2301110.

5. Shao-Qi Zhang^(#), Qiao Deng^(#), Qi Zhu^(#), Zhuang-Li Hu, Li-Hong Long, Peng-Fei Wu,Jin-Gang He,Hong-Sheng Chen,Zhenyu Yue, Jia-Hong Lu^(*), Fang Wang^(*), Jian-Guo Chen^(*).Cell type-specific NRBF2 orchestrates autophagic flux and adult hippocampal neurogenesis in chronic stress-induced depression.Cell Discovery.2023 Aug 29;9(1):90.

6. Jia-Jing Lu^(#); Peng-Fei Wu^(#);Jin-Gang He; Yu-Ke Li; Li-Hong Long; Xia-Ping Yao; Jia-Hao Yang;Hong-Sheng Chen; Xiang-Nan Zhang; Zhuang-Li Hu; Zhong Chen; Wang Fang^(*); Chen Jianguo^(*). BNIP3L/NIX-mediated mitophagy alleviates passive stress-coping behaviors induced by tumor necrosis factor-α.Molecular Psychiatry,2023 Mar 13. doi: 10.1038/s41380-023-02008-z

7. Hong-Sheng Chen^(#), Ji Wang^(#), Hou-Hong Li, Xiao Wang, Shao-Qi Zhang, Tan Deng, Yu-Ke Li, Ruo-Si Zou, Hua-Jie Wang, Rui Zhu, Wen-Long Xie, Gang Zhao^(*), Fang Wang^(*), Jian-Guo Chen^(*).Long noncoding RNA Gm2694 drives depressive-like behaviors in male mice by interacting with GRP78 to disrupt endoplasmic reticulum homeostasis.Science Advances. 2022 Dec 2;8(48):eabn2496.

8. Kuan Li^(#),Hong-Sheng Chen^(#), Di Li, Hou-Hong Li, Ji Wang, Lei Jia, Peng-Fei Wu, Li-Hong Long, Zhuang-Li Hu, Jian-Guo Chen^(*), Fang Wang^(*).SAR405, a Highly Specific VPS34 Inhibitor, Disrupts Auditory Fear Memory Consolidation of Mice via Facilitation of Inhibitory Neurotransmission in Basolateral Amygdala.Biological Psychiatry. 2019 Feb 1;85(3):214-225.