陳偉，教授，博士生導師，國家海外高層次青年人才（2022），湖北省“傑青”（2022），湖北省“百人計劃”（2021）入選者。陳教授2009年于武漢大學化學基地班專業獲理學學士學位，2014年在浙江大學化學系獲得博士學位。2015-2018年在美國國立衛生研究院National Institutes of Health（NIH）陳小元教授課題組從事博士後研究，2018-2020年于麻省理工學院（Massachusetts Institute of Technology, MIT）Robert S. Langer教授（美國三院院士，2021年增選為中國工程院外籍院士）課題組任研究科學家（Research Scientist）。2021年加入華中科技大學同濟醫學院88858cc永利官网藥理學系，任教授，兼任Chinese Chemical Letters和MedComm – Biomaterials and Application青年編委，以及Journal of Nanobiotechnology客座編輯。擔任湖北省藥理學會第十屆理事會理事，以及湖北省藥理學會黨支部青年委員和宣傳委員。

研究方向：智能器件，智控藥劑，手術輔助系統，診療增強系統，交叉轉化系統

聯系方式：weichen86@hust.edu.cn/weichensci@hotmail.com, 歡迎材料，化學，生物，醫學，工程等相關專業學生報考。

英文主頁： WeiChen_WorldChanging Group

ORCID: 0000-0003-3611-2760

陳教授長期從事利用生物啟發技術構建藥物制劑及智能器件用于疾病診斷治療的研究。圍繞增強藥物療效、提升病人依從性以及增加生物樣本采樣準确性等關鍵臨床問題，陳教授基于自身的研究背景，學習并借鑒自然界中存在生物原理，發展了系列生物啟發智能系統：（1）模拟生物硬組織形成，制備仿生礦化藥物制劑，逆轉了腫瘤耐藥性；（2）模拟生物自發驅動，開發了生物表面修飾及改性技術，調控生物體定向遷移特性；（3）模拟多刺生物防禦，成功構建了血糖響應型微針貼片，便利、長效調控病人血糖；（4）模拟刺頭蠕蟲寄生，創造超強生物粘附微針藥片，實現了大分子藥物高效口服遞送；（5）模拟鳥類舌尖采集食品，發展可富集病毒微針咽拭子提高了流行病病原體檢測準确性；（6）模拟海洋生物附着，制作了定向牽引抗菌微針創可貼，高效修複感染性全層皮膚缺損；（7）模拟豬籠草液體引流，發明了智能牙套裝置，實現口腔癌早期預警。已發表SCI論文40餘篇，包括Adv. Sci. (2024), Chem. Eng. J. (2024), Small (2024), Device (2023), Adv. Drug Deliv. Rev. (2023), ACS Nano (2023), Adv. Sci. (2023), J. Control. Release (2023) Sci. Adv. (2022), Nano Lett. (2022), Adv. Mater. (2022), ACS Nano (2022), J. Nanobiotechnology (2022), Theranostics (2021)，Matter (2020), Nano today (2020), Nano Lett. (2019), Adv. Drug Deliv. Rev. (2018), Nat. Commun. (2017), ACS nano (2017), Small (2014,2015), J. Control. Release (2015)等，其中影響因子大于11的論文20 餘篇，9項專利已獲授權。以重要骨幹身份參與了美國國立衛生研究院研究計劃，以及麻省理工學院-諾和諾德聯合研究項目，成果被NIH和MIT重點推薦，并被Cell出版社以及多家媒體相繼轉載。相關工作榮獲首批湖北省實驗室亮點科技成果，第十八屆“挑戰杯” 全國大學生課外學術科技作品競賽主賽道全國一等獎以及首批國家自然科學基金青年學生基礎研究項目（博士研究生項目指導老師）。陳教授工作已展現出較高的商業及臨床轉化潛力，相關工作已進入臨床試驗階段。

部分代表性工作概覽

近期新聞：

1. 華科大88858cc永利官网藥理學系陳偉教授團隊研究成果Small：“内外協同”工程化腸吻合策略實現腸瘘智能管理

2. 華科大88858cc永利官网陳偉教授團隊最新研究成果CEJ：受豬籠草啟發的“SALAD”護齒器用于口腔癌早期預警

3. 88858cc永利官网榮獲第十七屆全國大學生創新年會優秀學術論文獎

4. 恭喜陳偉教授課題組陳秀麗同學榮獲華中科技大學本科生自然科學創新基金項目資助

5. 88858cc永利官网陳偉教授團隊博士生龔宇晟獲首批國家自然科學基金青年學生基礎研究項目（博士研究生）資助

6. 88858cc永利官网在“挑戰杯”全國決賽主體賽中榮獲一等獎

7. 華中科技大學同濟醫學院陳偉教授ADDR：超聲可觸發/皮膚相關的微型器件用于智能藥物遞送與醫學診斷

8. 專訪華科大陳偉丨高科技、低成本，攪拌磁子化身「磁性機器人」，解決臨床腸道疾病精準靶向治療難題

9. 華中科大-陳偉&NUS-陳小元︱受小腸絨毛啟發的數學工程化底紋貼片用于各類粘膜高效生物标志物富集與藥物快速沉積

10. Chemical Engineering Journal88858cc永利官网陳偉教授團隊最新成果：基于光降解的鐵交聯海藻酸鈉微針貼片用于幹燥病治療

11. 受自加熱食品啟發，華科陳偉教授團隊研發可觸發微針系統，實現高效局部藥物遞送

12. 華科大本科生團隊一項科研成果顯示 變蟲為寶——“滅活血吸蟲蟲卵”或可輔助治療1型糖尿病

13. Adv Sci 綜述︱華中大陳偉團隊評述時空精準技術實現神經系統疾病的按需幹預

14. 華中大陳偉/王婷團隊《J. Nanobiotechnol.》：尖端搭載無佐劑日本血吸蟲蟲卵的不對稱微針貼片治療1型糖尿病

15. 陳小元/王琳/王征/陳偉ACS Nano: 微針圖案，用于疫苗接種

16. 華中大陳偉教授、麻省理工 Traverso教授等《Sci. Adv.》：生物大分子的口服遞送策略 - 動态全向粘附微針陣列系統

17. 感染性皮膚傷口的修複| 華中科技大學王琳/王征/陳偉教授團隊《Nano Letters》：仿生定向牽引抗菌絲膠微針高效修複感染性全層皮膚缺損

18. 華中科技大學88858cc永利官网陳偉教授等在Theranostics綜述搭載活性物質的智能微針系統在生物醫學中應用

19. 陳偉教授團隊《Advanced Materials》綜述未來科技改變生活：輕便小型智能可穿戴器件的創新與發展

20. 華中科技大重磅成果！自發富集病毒微針拭子，減少新冠檢測的“假陰性”！

21. 可自發調節的糖尿病治療貼片 美國國立衛生研究院陳小元團隊陳偉博士《Nature Communications》

代表性論文：

1 Liu, Yuan; Chen, Xiuli; Li, Guanyue; Xu, Jiarong; Zeng, Qi; Xu, Rengui; Gong, Yusheng; Chen, Wei*, Nepenthes-inspired saliva-amassing low-dosed risk-factor alerted detecting (SALAD) mouthguard for forewarning of the intraoral cancer, Chem. Eng. J. 2024, 502, 157802.

2 Li, Qilin^#; Wei, Chunyu^#; Xu, Luming; Zhang, Jiao; Li, Yuyu; Lu, Xiaohuan; Xu, Rengui; Guo, Honglian; Cao, Peng; Ouyang, Chenke; Xu, Jiarong; Chen, Wei*; Wang, Zheng*; Lin, Wang*, A smart semi-implantable device integrating microchannel-enhanced sampling and multiplex biochemical testing for deep wound monitoring and pathogen identification, Adv. Sci. 2024, 2407868.

3 Chen, Xiuli; Gong, Yusheng; Li, Min; Zeng, Qi; Xu, Rengui; Li, Xiaodong; Lu, Xiang; Song, Shang; Xu, Jiarong; Li, Guanyue; Yang, Jingwen; Jiao, Wenhao; Liu, Jiajing; Liu, Yuan; Liang, Xinting; He, Linxi; Xiao, Fei; Chen, Wei*, An interior/exterior collaboration-enhanced intestinal anastomosis (IECIA) for multi-tiered leakage complication management, Small 2024, 2408222.

4 Zeng, Qi#; Li, Guanyue#; Chen, Wei*, Ultrasound-activatable and skin-associated minimally invasive microdevices for smart drug delivery and diagnosis, Adv. Drug Deliv. Rev. 2023, 115133.

5 Gong, Yusheng; Tong, Shuai; Li, Xixuan; Chen, Xiuli; Liu, Yushuang; Li, Nan; Xu, Jiarong; Xu, Rengui; Guo, Yusong; Xiao, Fei; Chen, Xiaoyuan*; Chen, Wei*, Intestinal villi-inspired mathematically base-layer engineered microneedles (IMBEMs) for effective molecular exchange during biomarker enrichment and drug deposition in diversified mucosa, ACS Nano 2023, 7, 15696-15712.

6 Xu, Jiarong; Zeng, Qi; Chen, Xiuli; Guo, Honglian; Gong, Yusheng; Xu, Rengui; Cao, Peng; Wei, Chunyu; Xiao, Fei; Jiang, Dawei*; Chen, Wei*, Iron (III) cross-linked alginate microneedle patch for xerosis treatment based on controllable photodegradation, Chem. Eng. J. 2023, 145672.

7 Chen, Xiuli; Gong, Yusheng; Chen, Wei.*, Advanced temporally-spatially precise technologies for on-demand neurological disorder intervention, Adv. Sci. 2023, 10 (14), e2207436.

8 Wang, Zheng#*; Li, Qilin#; Cao, Peng#; Zhang, Jiao; Wu, Di; Xu, Rengui; Zhang, Yan; Xu, Yunruo; Liang, Tao; Chen, Wei*; Wang, Lin*; Chen, Xiaoyuan*, A biomimetic helical robot actuated by rotating magnetic field for targeted navigation and in situ prodrug activation to treat intestinal diseases, Device 2023, 1, 10064.

9 Xu, Rengui; Guo, Honglian; Chen, Xiuli; Xu, Jiarong; Gong, Yusheng; Cao, Peng; Wei, Chunyu; Xiao, Fei; Wu, Di; Chen, Wei*; Wang, Lin*; Wang, Zheng*, Smart hydrothermally responsive microneedle for topical tumor treatment, J. Control. Release 2023, 358, 566-578.

10 Dai, Jun#; Wei, Siming#; Xu, Jiarong#; Xue, Huiying; Chen, Zhaojun; Wu, Meng; Chen, Wei*; Lou, Xiaoding; Xia, Fan*; Wang, Shixuan*, Microneedle device delivering aggregation-induced emission photosensitizers for enhanced metronomic photodynamic therapy of cancer, ACS Appl. Mater. Interfaces 2023, 15, 16526–16538.

11 Yu, Yajie#; Lv, Bing#; Wu, Juntao; Chen, Wei*, Mussel-based biomimetic strategies in musculoskeletal disorder treatment: from synthesis principles to diverse applications, Int. J. Nanomedicine 2023, 18, 455-472.

12 Liu, Yuan; Huang, Ting; Qian, Zhiyong*; Chen, Wei*, Extensible and swellable hydrogel-forming microneedles for deep point-of-care sampling and drug deployment, Chin. Chem. Lett. 2023, 108103.

13 Chen, Wei; Wainer, Jacob; Ryoo, Si Won; Qi, Xiaoyue; Chang, Rrong; Li, Jason; Lee, Seung Ho; Min, Seokkee; Wentworth, Adam; Collins, Joy; Tamang, Siddartha; Ishida, Keiko; Hayward, Alison; Langer, Robert; Traverso, Giovanni*, Dynamic omnidirectional adhesive microneedle system for oral macromolecular drug delivery, Sci. Adv. 2022, 8, eabk1792.

14 Chen, Wei*; Wang, Zheng*; Wang, Lin*; Chen, Xiaoyuan*, Smart chemical engineering‐based lightweight and miniaturized attachable systems for advanced drug delivery and diagnostics, Adv. Mater. 2022, 34 (6), 2106701.

15 Huang, Haoming#; Hu, Dian#; Chen, Zhuo#; Xu, Jiarong; Xu, Rengui; Gong, Yusheng; Fang, Zhengming; Wang, Ting*; Chen, Wei*, Immunotherapy for type 1 diabetes mellitus by adjuvant-free Schistosoma japonicum-egg tip-loaded asymmetric microneedle patch (STAMP), J. Nanobiotechnology 2022, 20 (1), 377.

16 Li, Qilin#; Xu, Rengui#; Fan, Huiling#; Xu, Jiarong; Xu, Yunruo; Cao, Peng; Zhang, Yan; Liang, Tao; Zhang, Yang; Chen, Wei*; Wang, Zheng*; Wang, Lin*; Chen, Xiaoyuan*, Smart mushroom-inspired imprintable and lightly detachable (MILD) microneedle patterns for effective COVID-19 vaccination and decentralized information storage, ACS Nano 2022, 16 (5), 7512-7524.

17 Deng, Yan#; Yang, Cheng#; Zhu, Yuanyuan; Liu, Wenyu; Li, Heli; Wang, Liping; Chen, Wei*; Wang, Zheng*; Wang, Lin*, Lamprey-teeth-inspired oriented antibacterial sericin microneedles for infected wound healing improvement, Nano Lett. 2022, 22 (7), 2702-2711.

18 Liu, Yuan; Guo, Honglian; Xu, Rengui; Chen, Wei*, Smart intraoral systems for advanced drug delivery, MedComm – Biomaterials and Applications 2022, 1, e19.

19 Cai, Bo#; Gong, Yusheng#; Wang, Zheng*; Wang, Lin*; Chen, Wei*, Microneedle arrays integrated with living organisms for smart biomedical applications, Theranostics 2021, 11 (20), 10012-10029.

20 Chen, Wei#; Huang, Ting#; Shi, Kun; Chu, Bingyang; Qian, Zhiyong*, Chemotaxis-based self-accumulation of surface-engineered mitochondria for cancer therapeutic improvement, Nano Today 2020, 35, 100966.

21 Chen, Wei*; Cai, Bo; Geng, Zhi; Chen, Fenghua; Wang, Zheng*; Wang, Lin*; Chen, Xiaoyuan*, Reducing false negatives in COVID-19 testing by using microneedle-based oropharyngeal swabs, Matter 2020, 3 (5), 1589-1600.

22 Chen, Wei; Shi, Kun; Chu, Bingyang; Wei, Xiawei*; Qian, Zhiyong*, Mitochondrial surface engineering for multidrug resistance reversal, Nano Lett. 2019, 19 (5), 2905-2913.

23 Chen, Wei; Yung, Bryant C; Qian, Zhiyong*; Chen, Xiaoyuan*, Improving long-term subcutaneous drug delivery by regulating material-bioenvironment interaction, Adv. Drug Deliv. Rev. 2018, 127, 20-34.

24 Chen, Wei; Tian, Rui; Xu, Can; Yung, Bryant C.; Wang, Guohao; Liu, Yijing; Ni, Qianqian; Zhang, Fuwu; Zhou, Zijian; Wang, Jingjing; Niu, Gang; Ma, Ying; Fu, Liwu*; Chen, Xiaoyuan*, Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy, Nat. Commun. 2017, 1777.

25 Chen, Wei; Wang, Guohao; Yung, Bryant C.; Liu, Gang; Qian, Zhiyong*; Chen, Xiaoyuan*, Long-acting release formulation of exendin-4 based on biomimetic mineralization for type 2 diabetes therapy, ACS Nano 2017, 11 (5), 5062-5069.

26 Chen, Wei; Wang, Fang; Zhang, Xu; Hu, Jing; Wang, Xiaokun; Yang, Ke; Huang, Liyan; Xu, Meng; Li, Qingshan; Fu, Liwu*, Overcoming ABCG2-mediated multidrug resistance by a mineralized hyaluronan–drug nanocomplex, J. Mater. Chem. B 2016, 4 (41), 6652-6661.

27 Rao, Yuefeng#; Chen, Wei#; Liang, Xingguang; Huang, Yongzhuo; Miao, Jing; Liu, Lin; Lou, Yan; Zhang, Xingguo; Wang, Ben; Tang, Ruikang; Chen, Zhong; Lu, Xiaoyang*, Epirubicin‐loaded superparamagnetic iron‐oxide nanoparticles for transdermal delivery: cancer therapy by circumventing the skin barrier, Small 2015, 11 (2), 239-247.

28 Chen, Wei; Liu, Xueyao; Xiao, Yun; Tang, Ruikang*, Overcoming multiple drug resistance by spatial–temporal synchronization of epirubicin and pooled siRNAs, Small 2015, 11 (15), 1775-1781.

29 Chen, Wei; Fu, Liwu*; Chen, Xiaoyuan*, Improving cell-based therapies by nanomodification, J. Control. Release 2015, 219, 560-575.

30 Chen, Wei; Wang, Guangchuan; Tang, Ruikang*, Nanomodification of living organisms by biomimetic mineralization, Nano Res. 2014, 7 (10), 1404-1428.

31 Chen, Wei; Liu, Xueyao; Xiao, Yun; Chen, Yanhong; Wang, Guangchuan; Liu, Cuilian; Xu, Xurong; Tang, Ruikang*, Nano regulation of cisplatin chemotherapeutic behaviors by biomineralization controls, Small 2014, 10 (18), 3644-3649.

32 Chen, Wei; Xiao, Yun; Liu, Xueyao; Chen, Yanhong; Zhang, Jiaojiao; Xu, Xurong; Tang, Ruikang*, Overcoming cisplatin resistance in chemotherapy by biomineralization, Chem. Commun. 2013, 49 (43), 4932-4934.

33 Lv, Qiying#; Li, Xiaoye#; Tian, Xin; Fu, Da‐an; Liu, Huan; Liu, Jia; Song, Yu; Cai, Bo; Wang, Jian; Su, Qiangfei; Chen, Wei; Zou, Meizhen; Xiao, Fei; Wang, Shuai*; Wang, Zheng*; Wang, Lin*, A degradable and biocompatible supercapacitor implant based on functional sericin hydrogel electrode, Adv. Energy Mater. 2023, 2203814.

34 Liu, Huan; Qin, Sumei; Zhang, Hongyan; Chen, Zhongyin; Zhao, Yiwei; Liu, Jia; Deng, Yan; Liu, Miaodeng; Chen, Wei; Wang, Zheng*; Wang, Lin*, Silk sericin-based ros-responsive oxygen generating microneedle platform promotes angiogenesis and decreases inflammation for scarless diabetic wound healing, Adv. Funct. Mater. 2024, 2404461.

35 Lee, Seung Ho; Wan, Qianqian; Wentworth, Adam; Ballinger, Ian; Ishida, Keiko; Collins, Joy E; Tamang, Siddartha; Huang, Hen-Wei; Li, Canchen; Hess, Kaitlyn; Lopes, Aaron; Kirtane, Ameya; Lee, Jung Seung; Lee, Sejun; Chen, Wei; Wong, Kaithlyn; Selsing, George; Kim, Hyunjoon; Buckley, Stephen; Hayward, Alison; Langer, Robert; Traverso, Giovanni*, Implantable system for chronotherapy, Sci. Adv. 2021, 7 (48), eabj4624.

36 Zhou, Zijian; Chan, Alexander; Wang, Zhantong; Huang, Xiaolin; Yu, Guocan; Jacobson, Orit; Wang, Sheng; Liu, Yijing; Shan, Lingling; Dai, Yunlu; Shen, Zheyu; Lin, Lisen; Chen, Wei; Chen, Xiaoyuan*, Synchronous chemoradiation nanovesicles by x-ray triggered cascade of drug release, Angew. Chem. Int. Ed. Engl. 2018, 57 (28), 8463-8467.

37 Xia, Yuqiong*; Wang, Xiaofei; Cheng, He; Fang, Mei; Ning, Pengbo; Zhou, Yulu; Chen, Wei; Song, Hongjin, A polycation coated liposome as efficient siRNA carrier to overcome multidrug resistance, Colloids Surf. B Biointerfaces 2017, 159, 427-436.

38 Wang, Zhe; Zhang, Fuwu; Wang, Zhantong; Liu, Yijing; Fu, Xiao; Jin, Albert; Yung, Bryant C; Chen, Wei; Fan, Jing; Yang, Xiangyu; Niu, Gang; Chen, Xiaoyuan*, Hierarchical assembly of bioactive amphiphilic molecule pairs into supramolecular nanofibril self-supportive scaffolds for stem cell differentiation, J. Am. Chem. Soc. 2016, 138 (45), 15027-15034.

39 Liu, Zhaoming; Xiao, Yun; Chen, Wei; Wang, Yang; Wang, Ben; Wang, Gguangchuan; Xu, Xurong; Tang, Ruikang*, Calcium phosphate nanoparticles primarily induce cell necrosis through lysosomal rupture: the origination of material cytotoxicity, J. Mater. Chem B. 2014, 2 (22), 3480-3489.

40 Wang, Yang; Xiao, Yun; Zhou, Hangyu; Chen, Wei; Tang, Ruikang*, Ultra-high payload of doxorubicin and pH-responsive drug release in CuS nanocages for a combination of chemotherapy and photothermal therapy, RSC Adv. 2013, 3 (45), 23133-23138.

41 Du, Yuhao#; Zhang, Dan#; Chen, Wei; Zhang, Ming; Zhou, Yangyang; Zhou, Xiang*, Cationic N-confused porphyrin derivative as a better molecule scaffold for G-quadruplex recognition, Bioorgan. Med. Chem. 2010, 18 (3), 1111-1116.

42 Wang, Guangchuan; Li, Xiaofeng; Mo, Lijuan; Song, Zhiyong; Chen, Wei; Deng, Yongqiang; Zhao, Hui; Qin, Ede; Qin, Chengfeng*; Tang, Ruikang*, Eggshell-Inspired Biomineralization Generates Vaccines that Do Not Require Refrigeration, Angew. Chem. Int. Ed. Engl. 2012, 51 (42), 10576-10579.