朱鈴強，三級教授，博士生導師，耶魯大學博士後、華中學者特聘崗、國際雜志Journal of Alzheimer’s Disease（影響因子3.9）Senior Editor、全國百篇優秀博士論文提名獎獲得者，湖北省傑出青年基金獲得者，2016湖北省科協創新創業人才工程，華中科技大學中加神經疾病分子生物學聯合平台中方負責人，華中科技大學首屆學術前沿青年團隊負責人，首屆學術新人獎獲得者。目前研究方向：阿爾茨海默病的早期防治措施研究。承擔國家自然科學基金青年項目、面上項目、動物模型專項、重大計劃培育項目、國際合作（中德，中加）、海外港澳台基金共10項，科技部重大國際合作專項一項、美國阿爾茨海默病協會（Alzheimer Association）新研究者基金一項。目前以通訊作者和第一作者發表SCI論文48篇，其中包括Nature Neuroscience、Neuron、Mol Psychiatry、Nature Communications、Biological Psychiatry、Cell Death & Differ.、Mol Therapy、J Neurosci（6篇）、Aging Cell、Mol Neurobiol、Neurobiol Aging、J Neurochem等國際知名雜志，長期擔任國家自然科學基金委一審專家，意大利國家自然科學基金衰老組一組組長。

聯系方式

88858cc永利官网二号教學樓八樓803辦公室

電話：13308657291

Email：zhulq@mail.hust.edu.cn

QQ: 307728280

工作簡介

主要從事阿爾茨海默病（Alzheimer’s disease, AD）發病的分子機制及防治措施的研究。該病是一種高發于老齡人群的神經退行性疾病，AD患者的主要臨床表現為學習記憶能力漸進性減退，從而給其生活帶來了極大的不便，也給家庭和社會造成了極大的經濟和精神負擔。目前認為，AD早期突觸可塑性的紊亂是引起AD患者學習記憶障礙的主要原因，但其機制和可能的保護措施暫不明了。申請人針對AD突觸病變及神經環路異常的發生發展的機制展開了一系列的工作并取得了一定的科研成果，主要包括：
1，利用光遺傳學和轉基因技術，首次發現内嗅皮層II層的島細胞可以直接投射到海馬CA1的小清蛋白（PV）陽性的抑制性神經元形成ECII_PN–CA1 _PV神經環路，并且發現其功能在AD早期明顯降低，從而引起CA1腦區興奮/抑制失平衡并參與AD早期的學習記憶障礙；

2，系統研究了一系列miRNA在AD發病中的作用，如miR-124可以明顯下調Zif268的表達，進而抑制小鼠的學習記憶和社會交往能力；miR-218分子可以特異的作用于PTPa，而後者則可以特異性調控tau蛋白磷酸化相關的激酶GSK-3及酯酶PP2A的酪氨酸磷酸化，從而打破激酶和酯酶的平衡并且引起tau過度磷酸化和聚集的病變；

3，系統地研究并證明了糖原合酶激酶 3 激活在阿爾茨海默病突觸病變形成中的重要作用，并闡明了其作用機理是通過磷酸化突觸前 P/Q 型鈣通道阻礙了突觸前囊泡的釋放，從而抑制長時程增強（LTP）的形成。并且針對糖原合酶激酶 3 激活探讨了一系列的保護措施。

發表論文（*通訊作者）

1. Li X, Chen W, Pan K, Li H, Pang P, Guo Y, Shu S, Cai Y, Pei L, Liu D, Afewerky HK, Tian Q, Zhu LQ*, Lu Y*. Serotonin receptor 2c-expressing cells in the ventral CA1 control attention via innervation of the Edinger-Westphal nucleus. Nat Neurosci. 2018 Aug 13.

2. Li K, Wei Q, Liu FF, Hu F, Xie AJ, Zhu LQ*, Liu D*. Synaptic Dysfunction in Alzheimer's Disease: Aβ, Tau, and Epigenetic Alterations. Mol Neurobiol. 2018 55:3021-3032.

3. Wang X, Liu D, Huang HZ, Wang ZH, Hou TY, Yang X, Pang P, Wei N, Zhou YF, Dupras MJ, Calon F, Wang YT, Man HY, Chen JG, Wang JZ, Hébert SS, Lu Y, Zhu LQ*. A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer's Disease. Biol Psychiatry. 2018:83;395-405. (Highlight in this issue and commentary by Dr. Wang-Xia Wang)

4. Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ, Lu Y. Synaptic mechanism in Alzheimer's disease: a selective degeneration of an excitatory synaptic pathway in the CA1 hippocampus that controls spatial learning and memory in Alzheimer's disease. Mol Psychiatry. 2018 Feb;23(2):167.(Image)

5. Yang X, Yao C, Tian T, Li X, Yan H, Wu J, Li H, Pei L, Liu D, Tian Q, Zhu LQ*, Lu Y*. A novel mechanism of a memory loss in Alzheimer’s disease mice via degeneration of entorhinal-CA1 synapses. Mol Psychiatry. 2018: 23(2):199-210. (IF=13.7)

6. Wang DQ, Fu P, Yao C, Zhu LS, Hou TY, Chen JG, Lu Y, Liu D*, Zhu LQ*. Long non-coding RNAs, novel culprits or bodyguards in neu-rodegenerative diseases. Molecular Therapy-Nucleic Acid. 2018, 10(2):269-276.

7. Zhu H, Yan H, Tang N, Li X, Pang P, Li H, Chen W, Guo Y, Shu S, Cai Y, Pei L, Liu D, Luo MH, Man H, Tian Q, Mu Y*, Zhu LQ*, Lu Y*. Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses. Nat Commun. 2017, Nat Commun. 2017 Nov 22;8(1):1676.

8. Wu L, Meng J, Shen Q, Zhang Y, Pan S, Chen Z, Zhu LQ, Lu Y, Huang Y, Zhang G. Caffeine inhibits hypothalamic A(1)R to excite oxytocin neuron and ameliorate dietary obesity in mice. Nat Commun. 2017 Jun 27;8:15904.

9. Yang S, Jin H, Zhu Y, Wan Y, Opuku EN, Zhu LQ*, Hu B*. Diverse Functions and Mechanisms of Pericytes in Ischemic Stroke. Current Neuropharmacology, In press

10. Liu D, Tang H, Li XY, Deng MF, Wei N, Wang X, Zhou YF, Wang DQ, Fu P, Wang JZ, Hebert SS, Chen JG, Lu Y, Zhu LQ*. Targeting the HDAC2/HNF-4A/miR0101b/AMPK pathway rescues tauopathy and dendritic abnormalities in Alzheimer’s disease Molecular Therapy. 2017 Mar 1;25(3):752-764 (IF=6.938)

11. An TH, He QW, Xia YP, Chen SC, Baral S, Mao L, Jin HJ, Li YN, Wang MD, Chen JG, Zhu LQ*, Hu B*. MiR-181b Antagonizes Atherosclerotic Plaque Vulnerability Through Modulating Macrophage Polarization by Directly Targeting Notch1. Mol Neurobiol. 2016 Oct 8.

12. Shu S, Zhu HZ, Tang N, Chen W, Li X, Li H, Pei L, Liu D, Mu Y, Tian Q, Zhu LQ*, Lu Y*. Selective Degeneration of Entorhinal-CA1 Synapses in Alzheimer’s Disease via Activation of DAPK1. J Neurosci. 2016 Oct 19;36(42):10843-10852 (IF=5.9)

13. Liu YS, Dai X, Wu W, Yuan FF, Gu X, Chen JG, Zhu LQ*, Wu J*. The Association of SNAP25 Gene Polymorphisms in Attention Deficit/Hyperactivity Disorder: a Systematic Review and Meta-Analysis. Mol Neurobiol. 2017 Apr;54(3):2189-2200. (IF=5.3)

14. Xie AJ, Liu EJ, Huang HZ, Hu Y, Li K, Lu Y, Wang JZ*, Zhu LQ*. Cnga2 Knockout Mice Display Alzheimer's-Like Behavior Abnormities and Pathological Changes. Mol Neurobiol. 2016 Sep;53(7):4992-9.

15. Xiong YS, Liu FF, Liu D, Huang HZ, Wei N, Tan L, Chen JG, Man HY, Gong CX, Lu Y, Wang JZ, Zhu LQ*. Opposite effects of two estrogen receptors on tau phosphorylation regulation through disparate effects on the miR-218/PTPA pathway. Aging Cell, 2015, 14: 867–877.

16. Wang MD, Wang Y, Xia YP, Dai JW, Gao L, Wang SQ, Wang HJ, Mao L, Li M, Yu SM, Tu Y, He QW, Zhang GP, Wang L, Xu GZ, Xu HB, Zhu LQ*, Hu B*. High Serum MiR-130a Levels Are Associated with Severe Perihematomal Edema and Predict Adverse Outcome in Acute ICH. Mol Neurobiol. 2016 Mar;53(2):1310-21.

17. Li K, Liu FF, He CX, Huang HZ, Xie AJ, Hu F, Liu D, Wang JZ*, Zhu LQ*. Olfactory Deprivation Hastens Alzheimer-Like Pathologies in a Human Tau-Overexpressed Mouse Model via Activation of cdk5. Mol Neurobiol. 2016 Jan;53(1):391-401.

18. Liu D, Wei N, Man HY, Lu Y*, Zhu LQ*,Wang JZ*. The MT2 receptor stimulates axonogenesis and enhances synaptic transmission by activating Akt signaling. Cell Death & Differentiation. 2015 Apr;22(4):583-96.

19. Hu J, Huang HZ, Wang X, Xie AJ, Wang X, Liu D, Wang JZ*, Zhu LQ*. Glycogen synthase kinase-3 links the olfactory deficit to hippocampal impairments. Mol Neurobiol. 2015 Dec;52(3):1601-17.

20. Liu DY, Shen XM, Yuan FF, Guo OY, Zhong Y, Chen JG, Zhu LQ* Wu J*. The physiology of BDNF and its relationship with ADHD. Mol Neurobiol. 2015 Dec;52(3):1467-76.

21. Pei L, Shang Y, Jin H, Wang S, Wei N, Yan H, Wu Y, Yao C, Wang X, Zhu LQ*, Lu Y*. DAPK1-p53 Interaction Converges Necrotic and Apoptotic Pathways of Ischemic Neuronal Death. J Neurosci. 2014 May 7;34(19):6546-56.

22. Chen Y, Wang B, Liu D, Li JJ, Xue Y, Sakata K, Zhu LQ, Heldt SA, Xu H, Liao FF. Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment. J Neurosci. 2014 Feb 12;34(7):2464-70.

23. Wang X, Wang LP, Tang H, Shan WY, Wang X, Liu D, Wu YY, Tian Q, Wang JZ*, Zhu LQ*. Acetyl-l-carnitine rescues scopolamine-induced memory deficits by restoring insulin-like growth factor II via decreasing p53 oxidation. Neuropharmacology. 2014, 76(A) :80-87.

24. Wu YY, Wang X, Tan L, Liu D, Liu XH, Wang Q, Wang JZ*, Zhu LQ*. Lithium Attenuates Scopolamine-Induced Memory Deficits with Inhibition of GSK-3β and Preservation of Postsynaptic Components. J Alzheimers Dis. 2013, 37(3):515-527.

25. Tang H, Shen N, Jin HJ, Liu D*, Miao X*, Zhu LQ*. GSK-3β polymorphism discriminates bipolar disorder and schizophrenia: a systematic meta-analysis. Molecular Neurobiology. 2013,48(3):404-411.

26. Xiong YS, Wang DL, Tan L, Wang X, Chen LM, Gong CX, Wang JZ*, Zhu LQ*. Inhibiton of glycogen synthase kinase-3 reverses tau hyperphosphorylation induced by Pin1 downregulation. CNS & Neurological Disorders - Drug Targets. 2013, 12(3):436-443.

27. Zhao K, Wen R, Wang X, Pei L, Yang Y, Shang Y, Bazan N, Zhu LQ*, Tian Q*, Lu Y*. EPAC Inhibition of SUR1 Receptor Increases Glutamate Release and Seizure Vulnerability. J Neurosci. 2013,33(20):8861-8865. (IF=7.271)

28. Peng CX, Hu J, Liu D, Hong XP, Wu YY, Zhu LQ*, Wang JZ*. Disease-modified GSK-3b intervention by melatonin arrests the pathology and memory deficits in Alzheimer’s animal model. Neurobiology of Aging. 2013, 34(6):1555-1563. (IF=6.189)

29. Qu M, Jiang J, Liu XP, Tian Q, Chen LM, Yin G, Liu D, Wang JZ*, Zhu LQ*. Reduction and the intracellular translocation of EphB2 in Tg2576 mice and the effects of b-amyloid. Neuropathology and Applied Neurobiology. 2013 Oct;39(6):612-22. (IF=4.837)

30. Zhong R, Yang B, Tang H, Zou L, Song R, Zhu LQ*, Miao XP*. Meta-analysis of the association between DCDC2 polymorphisms and risk of Dyslexia. Molecular Neurobiology. 2013;47(1):435-442. (IF=5.735)

31. Wang X, Wang ZH, Wu YY, Tang H, Tan L, Wang X, Gao XY, Xiong YS, Liu D*, Wang JZ, Zhu LQ*. Melatonin attenuates scopolamine-induced memory/synaptic disorder by rescuing EPACs/miR-124/Egr1 pathsway. Molecular Neurobiology. 2013;47(1):373-381. (IF=5.735)

32. Wang SH, Liao XM, Liu D, Hu J, Yin YY, Wang JZ*, Zhu LQ*. NGF Promotes Long-term Memory Formation by Activating Poly(ADP-ribose)polymerase-1. Neuropharmacology. 2012;63(6):1085-1092 (IF=4.8)

33. Wu J, Xiao H, Sun H, Zou L, Zhu LQ*. Role of dopamine receprots in ADHD: a systematic meta-analysis. Molecular Neurobiology. 2012; 45(3):605-20. (IF=5.735)

34. Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu WH, Zhu LQ*, Wang JZ*, Lu Y*. EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation. Neuron, 2012;73(4):774-788. (IF=14.027)

35. Liao K, Liu D, Zhu LQ*. Enriched odor exposure decrease tau phosphorylation in the rat hippocampus and cortex. Neurosci Lett. 2012;507(1):22-26. (IF=2.055)

36. Hu J, Wang X, Liu D, Wang Q, Zhu LQ*. Olfactory deficits induce neurofilament hyperphosphorylation. Neurosci Lett. 2012; 506(2):180-183. (IF=2.055)

37. Zhou P, Chen Z, Zhao N, Liu D, Hu J, Guo ZY, Wang Q, Wang JZ*, Zhu LQ*. Acetyl-L-Carnitine attenuates homocysteine-induced Alzheimer-like histopathological and behavioral abnormalities. Rejuvenation Research. 2011, 14(6): 669-679. (IF=4.225)

38. Jiang X, Tian Q, Wang Y, Zhou XW, Xie JZ, Wang JZ, Zhu LQ*. Acetyl-L-Carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. J Neurochem. 2011;118(5):864-878.(IF=4.337)

39. Chen LM, Xiong YS, Kong FL, Qu M, Wang Q, Chen XQ, Wang JZ*, Zhu LQ*. Neuroglobin attenuates Alzheimer-like tau hyperphosphorylation by activating Akt signaling. J Neurochem. 2012 Jan;120(1):157-64 (IF=4.337)

40. Liu D, Zheng HY, Luo ZZ, Wang Q, Zhu LQ*. Effect of PP-2A on neurite outgrowth in neuronal cells. In Vitro Cell Dev-AN, 2010, 46(8): 702-707 (IF=1.312)

41. Zhu LQ, Liu D, Hu J, Cheng J, Wang SH, Wang Q, Wang F, Chen JG, Wang JZ. GSK-3b inhibits presynaptic vesicle exocytosis by phosphorylating P/Q-type calcium channel and interrupting SNARE complex formation. J Neurosci. 2010;30(10):3624-33. (IF:7.49)

42. Zhu LQ, Zheng HY, Peng CX, Liu D, Li HL, Wang Q, Wang JZ. Protein phosphatase 2A facilitates functional axonogenesis by dephosphorylating CRMP2. J Neurosci. 2010;30(10):3839-48. (IF:7.49)

43. Yin YY, Liu H, Liu Z, Cong XB, Wang Q, Wang JZ*, Zhu LQ*. Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats. J Alzheimer’s Disease 2010;19(2):735-46. (IF=5.0)

44. Shi HR, Zhu LQ*, Wang SH, Liu XA, Tian Q, Zhang Q, Wang Q, Wang JZ*. (2008). 17 β-estradiol attnuates glycogen synthase kinase-3β activation and tau hyperphosphorylation in Akt-independent manner. J Neural Transmission 115(6):879-888. (IF:2.938)

45. Liu XA, Zhu LQ*, Zhang Q, Shi HR, Wang SH, Wang Q, Wang JZ*. (2008). Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A. Neurochemical Res 2008 Sep;33(9):1811-20. (IF:2.18)

46. Zhu LQ, Wang SH, Liu D, Yin YY, Tian Q, Wang XC, Wang Q, Chen JG, Wang JZ (2007). Activation of glycogen synthase kinase-3 inhibits long term potentiation with synapse-associated impairments. J Neurosci 27:12211-12220. (IF:7.49)

47. Wang SH, Zhu LQ, Wang Q, et al. (2007). Inhibition of Melatonin Biosynthesis Induces Neurofilament Hyperphosphorylation with Activation of Cyclin-dependent Kinase 5. Neurochem Res 32(8):1329-1335. (IF:2.18)

48. Zhu LQ, Wang SH, Ling ZQ, et al. (2004). Effect of inhibiting melatonin biosynthesis on    spatial memory retention and tau phosphorylation in rat. J Pineal Res 37 (2):71-77. (IF:4.228)

承擔項目

2008年，國家自然科學基金青年基金，30800342，糖原合酶激酶3在阿爾茨海默病突觸病變中的作用和機制，20萬元，負責人 2009.1.1-2011.12.31

2009年，國家自然科學基金面上基金，30971478，雌激素受體beta在衰老相關記憶障礙中的作用和機制，31萬元，負責人 2010.1.1-2012.12.31

2009年，華中科技大學首屆學術新人獎人才基金，20萬，負責人

2010年，教育部新世紀優秀人才支持計劃，NCET-10-0421，神經細胞粘附分子唾液酸化失調引起阿爾茨海默病突觸病變的分子機理，50萬，負責人 2011.5-2014.4

2011年，美國阿爾茨海默協會基金，NIRG-11-205737，Role of EphB2

signal in tau pathology in Alzheimer's Disease，10萬美金，負責人（目前中國獲得該基金的隻有三人） 2011.10-2013.9

2011年，國家自然科學基金重大計劃，91132725, 嗅覺環境變化對内嗅皮層-海馬環路功能的影響及在阿爾茨海默病樣記憶障礙中的作用80萬元，負責人 2012.1.1-2014.12.31

2012年，中國科技部-加拿大國際合作專項基金，2011DFG33250，運用新型基因技術探索糖原合酶激酶3在腦功能和疾病中作用的合作研究，170萬元，負責人 2012.4-2015.3

2013年，國家自然科學基金委員會（NSFC）與加拿大魁北克醫學研究基金會（FRQS）合作研究項目，81361120245，整體水平研究EPAC/miR-124信号通路在阿爾茲海默發病中的作用和機制，100萬元，負責人 2013.1.-2015.12.31

2014年，湖北省傑出青年基金, 2014CFA017, 組蛋白去乙酰化酶2調控AD腦内澱粉樣蛋白生成和tau病變的機制,10萬元，負責人，2014.1-2016.12.

2014年,  國家自然科學基金委員會海外及港澳學者合作研究基金, 81428009, 智障相關蛋白KIAA202在神經元發育及突觸形成中的作用,20萬元,第一參與人(境内負責人),2015.1-2016.12.

2015年，國家自然科學基金面上項目，31571039，長鍊非編碼RNA AK036689在阿爾茨海默病早期海馬突觸環路功能障礙中的作用，76.8萬元，負責人，2016.1.1-2019.12.31.

2015年，國家特支計劃青年拔尖人才專項基金，190萬元

2015年，華中科技大學首屆青年學術團隊專項基金，60萬元/年持續資助

2016年，國家自然科學基金重大計劃，91632114, 長鍊非編碼mSYT-AS異常在阿爾茨海默病ECIIPN-CA1PV環路功能障礙中作用研究，60萬元，負責人 2017.1.1-2019.12.31

2017年，國家自然科學基金面上項目動物模型專項，81771150，運用光遺傳可調控性轉基因小鼠模型研究基底前腦-海馬DG膽堿能神經環路損傷在阿爾茨海默病早期模式分别障礙中的作用，80萬元，負責人，2018.1.1-2021.12.31

2017年，國家自然科學基金創新群體項目，31721002，記憶神經環路研究群體，1050萬元，參與人，2018.1.1-2023.12.31

2017年，國家自然科學基金委員會（NSFC）與德國科學基金會（DFG）合作研究項目，81761138043，微小RNA調節網絡在阿爾茨海默病神經環路功能障礙中的作用(MiRNetAD)，180萬元，負責人，2018.1.1-2020.12.31

2018年,  國家自然科學基金委員會海外及港澳學者合作研究基金延續性項目, 81829002, miR-138/Nrgn信号通路在智障相關蛋白KIDLIA缺失所緻自閉症樣社交異常及突觸紊亂中的作用和機理,180萬元,第一參與人(境内負責人),2019.1-2022.12.

專利

朱鈴強;王雄;王玉田;劉丹;黃和周。一種防治老年癡呆的藥物。專利号：2014106681340，授權日，2017.6.16日