黃波，華中科技大學同濟醫學院生物化學與分子生物學系教授，同時任中國醫學科學院基礎醫學研究所&北京協和醫學院，協和學者特聘教授兼免疫學系副主任，中國免疫學會副秘書長。1999年和2002年先後在華中科技大學同濟醫學院獲得生物化學與分子生物學碩士和博士學位。2002年5月至2006年2月先後在karolinska  institute（乳腺癌的遺傳學）、加拿大university of calgary（腦膠質瘤的生物學）、美國mount sinai school of medicine（腫瘤免疫學和免疫治療）從事博士後研究。回國後，在2008年破格晉升為教授、博士生導師。先後獲得首屆“中國免疫學青年學者獎”、“教育部新世紀優秀人才支持計劃”資助、“湖北省有突出貢獻的中青年專家”稱号、中國醫學科學院和北京協和醫學院協和學者和特聘教授、“國家傑出青年基金”資助、“國家百千萬人才和有突出貢獻中青年專家”稱号，。現任中國免疫學會常務理事以及中國生物化學與分子生物學會理事，中國抗癌協會腫瘤生物治療專業委員會委員，并擔任cancer letters，european journal of immunology等雜志的編委。

實驗室簡介

實驗室自2008年成立以來，主要研究方向為腫瘤免疫，腫瘤生物治療，腫瘤生物學，腫瘤代謝等。在nature materials、nature communications、blood、embo reports、cancer research、cancer immunology research、oncoimmunology、journal of immunology等相關領域國際主流雜志發表sci文章60多篇，30篇論文的影響因子>;5.0，sci引用2000餘次。實驗室目前有在站博士後5名，博士研究生8名，碩士研究生11名。

實驗室網站鍊接：http://huangbolab.cn/

代表性論文

2015 publications

1)ruihua ma, tiantian ji, degao chen, wenqian dong, huafeng zhang, xiaonan yin, jingwei ma, xiaoyu liang, yi zhang, guanxin shen, xiaofeng qin,bo huang*. tumor cell-derived microparticles polarize m2 tumor-associated macrophages for tumor progression. oncoimmunology. 2015. accepted (if: 6.266)

2)tang k, hu l, ma j, zhang h, zhang y, li y, ma r, luo s, liu d, long g, han m, liu s, song a, shen m, hu g,huang b*. brief report: human mesenchymal stem-like cells facilitate floating tumorigenic cell growth via glutamine-ammonium cycle. stem cells. 2015;33(9):2877-84. (if: 6.523)

3)wang z, cheng q, tang k, sun y, zhang k, zhang y, luo s, zhang h, ye d,huang b*.lipid mediator lipoxin a4 inhibits tumor growth by targeting il-10-producing regulatory b (breg) cells.. cancer lett. 2015;364(2):118-24. (if: 5.621)

4)zhang h,huang b*. tumor cell-derived microparticles: a new form of cancer vaccine. oncoimmunology. 2015;4(8):e1017704. (if: 6.266)

5)cao y, liu c, gu z, zhang y, duan y, zhang y, zhang h, tang k,huang b*. microparticles mediate human papillomavirus type 6 or 11 infection of human macrophages. cell mol immunol. 2015 apr 20. (if: 4.112)

6)li y, luo s, ma r, liu j, xu p, zhang h, tang k, ma j, zhang y, liang x, sun y, ji t, wang n,huang b*. upregulation of cytosolic phosphoenolpyruvate carboxykinase is a critical metabolic event in melanoma cells that repopulate. cancer res. 2015;75(7):1191-6. (if:9.329)

7)zhang h, tang k, zhang y, ma r, ma j, li y, luo s, liang x, ji t, gu z, lu j, he w, cao x, wan y,huang b*. cell-free tumor microparticle vaccines stimulate dendritic cells via cgas/sting signaling. cancer immunol res. 2015;3(2):196-205. (if:3.857)

8)huang b*. tumor microenvironment: a mechanical force link. sci china life sci. 2015;58(2):202-4. (if: 1.688)

2014 publications

9)zhao j, zeng w, cao y, liang x,huang b*. immunotherapy of hpv infection-caused genital warts using low dose cyclophosphamide. expert rev clin immunol. 2014;10;791-9. (if:2.484)

2013 publications

10)ma r, zhang w, tang k, zhang h, zhang y, li d, li y, xu p, luo s, cai w, ji t, katirai f, ye d,huang b*. switch of glycolysis to gluconeogenesis by dexamethasone for treatment of hepatocarcinoma. nat commun. 2013;4:2508. (if: 11.47)

11)li d, cai w, gu r, zhang y, zhang h, tang k, xu p, katirai f, shi w, wang l, huang t,huang b*.th17 cell plays a role in the pathogenesis of hashimoto's thyroiditis in patients.clin immunol. 2013;149(3):411-20. (if:3.672)

12)bian j, li b, zeng x, hu h, hong y, ouyang h, zhang x, wang z, zhu h, lei p,huang b*, shen g. mutation of tgf-β receptor ii facilitates human bladder cancer progression through altered tgf-β1 signaling pathway. int j oncol. 2013;43(5):1549-59. (if:3.025)

13)ma j, cai w, zhang y, huang c, zhang h, liu j, tang k, xu p, katirai f, zhang j, he w, ye d, shen gx,huang b*. innate immune cell-derived microparticles facilitate hepatocarcinoma metastasis by transferring integrin αmβ2 to tumor cells. j immunol. 2013;191:3453-61. (if: 4.922)

14)xu z, zhao j, zhang h, ke t, xu p, cai w, katirai f, ye d, huang y,huang b*. spontaneous miscarriages are explained by the stress/glucocorticoid/lipoxin a4 axis. j immunol. 2013;190:6051-8. (if: 4.922)

2012 publications

15)liu j, tan y, zhang h, zhang y, xu p, chen j, poh yc, tang k, wang n,huang b*. soft fibrin gels promote selection and growth of tumorigenic cells. nat mater. 2012;11:734-41. (if: 36.503)

16)tang k, zhang y, zhang h, xu p, liu j, ma j, lv m, li d, katirai f, shen gx, zhang g, feng zh, ye d,huang b*. delivery of chemotherapeutic drugs in tumour cell-derived microparticles. nat commun. 2012;3:1282. (if: 11.47)

17)zhang y, zhang r, zhang h, liu j, yang z, xu p, cai w, lu g, cui m, schwendener ra, shi hz, xiong h,huang b*. microparticles released by listeria monocytogenes-infected macrophages are required for dendritic cell-elicited protective immunity. cell mol immunol. 2012;9:489-96. (if: 4.112)

18)li d, jia h, zhang h, lv m, liu j, zhang y, huang t,huang b*. tlr4 signaling induces the release of microparticles by tumor cells that regulate inflammatory cytokine il-6 of macrophages via microrna let-7b. oncoimmunology. 2012;1:687-693. (if: 6.266)

19)lv m, zhang x, jia h, li d, zhang b, zhang h, hong m, jiang t, jiang q, lu j, huang x,huang b*. an oncogenic role of mir-142-3p in human t cell acute lymphoblastic leukemia (t-all) by targeting glucocorticoid receptor alpha and camp/pka pathways. leukemia. 2012;26:769-77. (if:10.431)

2011 publications

20)liu j, zhao j, hu l, cao y,huang b*. low dosages: new chemotherapeutic weapons on the battlefield of immune-related diseases. cell mol immunol. 2011;8:289-95. (if: 4.112)

21)liu j, zhang y, zhao j, yang z, li d, katirai f,huang b*. mast cell: insight into remodeling a tumor microenvironment. cancer metastasis rev. 2011;30:177-84. (if:7.234)

22)ouyang x, yang z, zhang r, arnaboldi p, lu g, li q, wang w, zhang b, cui m, zhang h, liang-chen j, qin l, zheng f,huang b*, xiong h*. potentiation of th17 cytokines in aging process contributes to the development of colitis. cell immunol. 2011;266:208-17. (if: 1.924)

2010publications

23)zhang b, jia h, liu j, yang z, jiang t, tang k, li d, huang c, ma j, shen gx, ye d,huang b*. depletion of t regulatory cells facilitates growth of established tumors: a mechanism involving the regulation of myeloid-derived suppressor cells by lipoxin a4. j immunol. 2010;185:7199-206. (if: 4.922)

24)tang k, liu j, yang z, zhang b, zhang h, huang c, ma j, shen gx, ye d,huang b*. microparticles mediate enzyme transfer from platelets to mast cells: a new pathway for lipoxin a4 biosynthesis. biochem biophys res commun. 2010;400:432-6. (if: 2.297)

25)zhao j, cao y, lei z, yang z, zhang b,huang b*. selective depletion of cd4+cd25+foxp3+ regulatory t cells by low-dose cyclophosphamide is explained by reduced intracellular atp levels. cancer res. 2010;70:4850-8. (if: 9.329)

26)cao y, zhao j, yang z, cai z, zhang b, zhou y, shen gx, chen x, li s,huang b*. cd4+foxp3+ regulatory t cell depletion by low-dose cyclophosphamide prevents recurrence in patients with large condylomataacuminata after laser therapy. clin immunol. 2010;136:21-29. (if: 3.672)

27)zhou y, wang s, ma jw, lei z, zhu hf, lei p, yang zs, zhang b, yao xx, shi c, sun lf, wu xw, ning q, shen gx,huang b*. hbx-induced expression of the cxc chemokine ip-10 is mediated through activation of nf-kappab and increases migration of leukocytes. j biol chem. 2010;285:12159-68. (if:4.573)

28)yang z, zhang b, li d, lv m, huang c, shen gx,huang b*. mast cells mobilize myeloid-derived suppressor cells and treg cells in tumor microenvironment via il-17 pathway in murine hepatocarcinoma model. plos one. 2010;5:e8922. (if:3.234)

29)li b, lei z, lichty bd, li d, zhang gm, feng zh, wan y,huang b*. autophagy facilitates major histocompatibility complex class i expression induced by ifn-gamma in b16 melanoma cells. cancer immunol immun. 2010;59:313-21. (if:3.941)

30)yang z, lei z, li b, zhou y, zhang gm, feng zh, zhang b, shen gx,huang b*. rapamycin inhibits lung metastasis of b16 melanoma cells through down-regulating alphav integrin expression and up-regulating apoptosis signaling. cancer sci. 2010; 101:494-500. (if: 3.523)

2009 publications

31)lei z, li b, yang z, fang h, zhang gm, feng zh,huang b*. regulation of hif-1alpha and vegf by mir-20b tunes tumor cells to adapt to the alteration of oxygen concentration. plos one. 2009; 4:e7629.(if:3.234)

32)zhao j, lei z, liu y, li b, zhang l, fang h, song c, wang x, zhang gm, feng zh,huang b*. human pregnancy upregulates tim-3 in innate immune cells for systemic immunity. j immunol. 2009; 182:6618-24. (if:4.922)

33)huang b*, zhao j, lei z, shen s, li d, shen gx, zhang gm, feng zh*. mir-142-3p regulates camp production in t cells by targeting adenylyl cyclase 9 mrna. embo rep. 2009; 10:180-5. (if:9.055)

34)lei z, zhang gm, hong m, feng zh,huang b*. fusion of dendritic cells and cd34+cd38- acute myeloid leukemia (aml) cells potentiates targeting aml-initiating cells by specific ctl induction. j immunother. 2009; 32:408-14. (if:4.008)

2008 publications

35)song c, luo l, lei z, li b, liang z, liu g, li d, zhang g,huang b*, feng zh*. il-17-producing alveolar macrophages mediate allergic lung inflammation related to asthma. j immunol. 2008; 181:6117-24. (if:4.922)

36)huang b*, lei z, zhang gm, li d, song c, li b, liu y, yuan y, unkeless j, xiong h, feng zh*.scf-mediated mast cell infiltration and activation exacerbate the inflammation and immunosuppression in tumor microenvironment. blood. 2008; 112:1269-79.(if: 10.452)

37)gong w, zhang gm, liu y, lei z, li d, yuan y,huang b*, feng zh*. ifn-γ withdrawal after immunotherapy potentiates b16 melanoma invasion and metastasis by intensifying tumor integrin αvβ3 signaling. int j cancer. 2008; 123:702-708.(if: 5.085)

38)cao y, zhao j, lei z, shen s, liu c, li d, liu j, shen gx, zhang gm, feng zh,huang b*. local accumulation of foxp3+ regulatory t cells: evidence for an immune evasion mechanism in patients with large condylomata acuminata. j immunol. 2008; 180:7681-6. (if:4.922)

39)lei z, liu g, huang q, lv m, zu r, zhang gm, feng zh,huang b*. scf and il-31 rather than il-17 and baff are potential indicators in patients with allergic asthma. allergy. 2008; 63:327-32. (if:6.028)

40)huang b*, zhao j, unkeless jc, feng zh, xiong h*. tlr signaling by tumor and immune cells: a double-edged sword. oncogene. 2008; 27:218-24. (if:8.459)

2007 publications

41)xiao h,huang b(co-first author), yuan y, li d, han lf, liu y, gong w, wu fh, zhang gm, feng zh. soluble pd-1 facilitates 4-1bbl-triggered antitumor immunity against murine h22 hepatocarcinoma in vivo. clin cancer res. 2007; 13:1823-30. (if: 8.722)

42)liu y,huang b(co-first author), yuan y, gong w, xiao h, li d, yu zr, wu fh, zhang gm, feng zh.inhibition of hepatocarcinoma and tumor metastasis to liver by gene therapy with recombinant cbd-hepii polypeptide of fibronectin. int j cancer. 2007; 121:184-92. (if: 5.085)

43)huang b, zhao j, shen s, li h, he kl, shen gx, mayer l, unkeless j, li d, yuan y, zhang gm, xiong h, feng zh. listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. cancer res. 2007; 67:4346-52.

44)huang b, lei z, zhao j, gong w, liu j, chen z, liu y, li d, yuan y, zhang gm, feng zh. ccl2/ccr2 pathway mediates recruitment of myeloid suppressor cells to cancers. cancer lett. 2007; 252:86-92. (if: 5.621)

2006 publications

45)huang b, pan py, li q, sato ai, levy de, bromberg j, divino cm, chen sh. gr-1+cd115+ immature myeloid suppressor cells mediate the development of tumor specific t regulatory cell and t cell anergy. cancer res. 2006; 66:1123-31. (if:9.329)

2005 publications

46)huang b, zhao j, li h, he kl, chen y, chen sh, mayer l, unkeless jc, xiong h. toll like receptor(tlr) on tumor cells facilitate evasion of immune surveillance. cancer res. 2005; 65:5009-14. (if:9.329)