張冬雷，華中科技大學88858cc永利官网生物化學與分子生物學教授，博士生導師。國家自然科學基金優秀青年基金獲得者。2004年于北京師範大學獲學士學位，2007年中國科學院遺傳與發育生物學研究所獲碩士學位，2013年于美國羅格斯新澤西州立大學（Rutgers University-New Brunswick）獲博士學位，2013至2017年在美國芝加哥大學（University of Chicago）從事博士後研究。主要研究領域為膜性和非膜性亞細胞結構的功能及調控機制。以模式生物做為研究材料，探索非編碼RNA和細胞細胞骨架蛋白在生殖系統及胚胎早期發育過程中的功能和作用機制。近年來以第一作者或通訊作者在Science、Journal of Cell Biology、eLife、Current Biology等國際主要期刊發表多篇學術論文。

研究方向：非編碼piRNA對基因表達的轉錄後和表觀遺傳學調控；細胞骨架在生殖系統和早期胚胎發育過程中的組裝

聯系方式：華中科技大學同濟醫學院88858cc永利官网2号樓1326室

Email: zhang_donglei@hust.edu.cn

主要學術論文

1.Zhang, D.*, Tu, S.*, Stubna, M., Wu, W-S., Huang, W-C., Weng, Z., and Lee, H-C. (2018) The piRNA targeting rules and the resistance to piRNA silencing in endogenous genes. Science 359 (6375), 587-592 (*equal contribution)

2.Wei-Sheng Wu, Wei-Che Huang, Jordan S Brown,Donglei Zhang, Xiaoyan Song, Hao Chen, Shikui Tu, Zhiping Weng, Heng-Chi Lee (2018) pirScan: a webserver to predict piRNA targeting sites and to avoid transgene silencing in C. elegans.Nucleic acids research46(W1), W43-W48

3.Liu, X.*, Li, D.*,Zhang, D., Yin, D., Zhao, Y., Ji, C., Zhao, X., Li, X., He, Q., Chen, R., Hu, S., and Zhu, L. (2018) A novel antisense long noncoding RNA, TWISTED LEAF, maintains leaf blade flattening by regulating its associated sense R2R3-MYB gene in rice. New Phytologist. doi: 10.1111/nph.15023 (* equal contribution)

4.Zhang, D., Dubey, J., Koushika, S.P., and Rongo, C. RAB-6.1 and RAB-6.2 promote retrograde transport in C. elegans. PLoS ONE 11(2): e0149314. doi:10.1371/journal.pone.0149314

5.Zhang, D.* and Glotzer, M.* (2015) Cytokinesis: Placing the Furrow in Context. Current Biology 25, R1183-R1185 (* corresponding authors)

6.Zhang, D.and Glotzer, M. (2015) The RhoGAP activity of CYK-4/MgcRacGAP functions non-canonically by promoting RhoA activation during cytokinesis. eLife 4. doi: 10.7554/eLife.08898

7.Basant, A., Lekomtsev, S.*, Tse, Y.C.*,Zhang, D.*, Longhini, K., Petronczki, M., and Glotzer, M. (2015) Aurora B kinase promotes cytokinesis by inducing centralspindlin oligomers that associate with the plasma membrane. Developmental Cell 32, 204-215 (* equal contributions, listed alphabetically)

8.Zhang, D.and Glotzer, M. (2014) Efficient site-specific editing of the C. elegans genome. bioRxiv. doi: 10.1101/007344 (featured by Faculty of 1000,http://f1000.com/prime/718524877)

9.Zhang, D., Isack, N.R., Glodowski, D.R., Liu, J., Chen, C.C., Xu, X.Z.S., Grant, B.D., and Rongo, C. (2012) RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway. Journal of Cell Biology 196, 85-101

10.Wan, L., Li, D.,Zhang, D., Liu, X., Fu, W.J., Zhu, L., Deng, M., Sun, F., and Qian, M. (2008). Conservation and implications of eukaryote transcriptional regulatory regions across multiple species. BMC Genomics 9, 623-641